日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Calorie Restriction Upregulates Islet PD-L1 Signaling and Decreases the Risk of Autoimmune Diabetes Onset in NOD Mice

热量限制可上调NOD小鼠胰岛PD-L1信号通路并降低自身免疫性糖尿病的发病风险

Cambraia, Amanda; Schleh, Michael; Cartailler, Jean-Phillipe; Cutler, Melanie; Dos Santos, Cristiane; Many, Gina; Kim, Hyeyoon; Kim, Young-Mo; Nakayasu, Ernesto S; Moglienko, Denis A; E Drigo, Rafael Arrojo

Impaired suppression of fatty acid release by insulin is a strong predictor of reduced whole-body insulin-mediated glucose uptake and skeletal muscle insulin receptor activation.

胰岛素对脂肪酸释放的抑制作用受损是全身胰岛素介导的葡萄糖摄取减少和骨骼肌胰岛素受体激活减少的强有力预测指标

Schleh Michael W, Ryan Benjamin J, Ahn Cheehoon, Ludzki Alison C, Van Pelt Douglas W, Pitchford Lisa M, Chugh Olivia K, Luker Austin T, Luker Kathryn E, Samovski Dmitri, Abumrad Nada A, Burant Charles F, Horowitz Jeffrey F

TMIC-81. Targeting TGFβ-mediated B cell suppression enhances anti-PD-1 efficacy in glioblastoma

TMIC-81。靶向TGFβ介导的B细胞抑制可增强抗PD-1疗法在胶质母细胞瘤中的疗效。

Schleh, Michael; Cambraia, Amanda; Cutler, Melanie; Ferguson, Gabriel; Arrojo E Drigo, Rafael; Hou, David; Wang, Si; Castro, Brandyn A; Katz, Joshua L; Dapash, Mark; Arrieta, Victor A; Vazquez-Cervantes, Gustavo I; Wan, Hanxiao; Billingham, Leah K; Du, Rebecca; Murphy, Alina R; Lopez-Rosas, Aurora; Han, Yu; Patel, Ronit V; Chia, Tzu-Yi; Dmello, Crismita C; Zhang, Peng; Sheppard, Dean; Sonabend, Adam M; Miska, Jason M; Lesniak, Maciej S; Heiland, Dieter Henrik; Lee-Chang, Catalina

Knockdown of microglial iron import gene, Slc11a2, worsens cognitive function and alters microglial transcriptional landscape in a sex-specific manner in the APP/PS1 model of Alzheimer's disease

在阿尔茨海默病的 APP/PS1 模型中,小胶质细胞铁输入基因 Slc11a2 的敲低会导致认知功能恶化,并以性别特异性的方式改变小胶质细胞的转录格局

Katrina Volk Robertson, Alec S Rodriguez, Jean-Philippe Cartailler, Shristi Shrestha, Michael W Schleh, Kyle R Schroeder, Arianna M Valenti, Alec T Kramer, Fiona E Harrison, Alyssa H Hasty

Microglial-specific knockdown of iron import gene, Slc11a2, blunts LPS-induced neuroinflammatory responses in a sex-specific manner

小胶质细胞特异性敲低铁输入基因Slc11a2,可以性别特异性方式减弱LPS诱导的神经炎症反应。

Katrina Volk Robertson ,Michael W Schleh ,Fiona E Harrison ,Alyssa H Hasty

Deficiency of the Hemoglobin-Haptoglobin Receptor, CD163, Worsens Insulin Sensitivity in Obese Male Mice

血红蛋白-触珠蛋白受体CD163的缺乏会加剧肥胖雄性小鼠的胰岛素敏感性

Schleh, Michael W; Ameka, Magdalene K; Rodriguez, Alec S; Hasty, Alyssa H

Insulin at the intersection of thermoregulation and glucose homeostasis

胰岛素在体温调节和葡萄糖稳态中的作用

Winn, Nathan C; Schleh, Michael W; Garcia, Jamie N; Lantier, Louise; McGuinness, Owen P; Blair, Joslin A; Hasty, Alyssa H; Wasserman, David H

Deficiency of the hemoglobin-haptoglobin receptor, CD163, worsens insulin sensitivity in obese male mice

血红蛋白-触珠蛋白受体CD163的缺乏会加剧肥胖雄性小鼠的胰岛素敏感性。

Schleh, Michael W; Ameka, Magdalene; Rodriguez, Alec; Hasty, Alyssa H

Metaflammation in obesity and its therapeutic targeting

肥胖症中的代谢炎症及其治疗靶点

Schleh, Michael W; Caslin, Heather L; Garcia, Jamie N; Mashayekhi, Mona; Srivastava, Gitanjali; Bradley, Anna B; Hasty, Alyssa H

Both moderate- and high-intensity exercise training increase intramyocellular lipid droplet abundance and modify myocellular distribution in adults with obesity.

中等强度和高强度运动训练均可增加肥胖成年人肌细胞内脂滴的含量,并改变肌细胞的分布

Schleh Michael W, Ahn Cheehoon, Ryan Benjamin J, Chugh Olivia K, Luker Austin T, Luker Kathryn E, Gillen Jenna B, Ludzki Alison C, Van Pelt Douglas W, Pitchford Lisa M, Zhang Tao, Rode Thomas, Howton Suzette M, Burant Charles F, Horowitz Jeffrey F