日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A critical residue mediates proper assembly and gating of GIRK2 channels

一个关键残基介导GIRK2通道的正确组装和门控。

Nguyen, Ha; Mount, Jonathan; Hutchinson, Keino; Zhao, Yihan; Zhao, Yulin; Glaaser, Ian W; Yuan, Peng; Schlessinger, Avner; Slesinger, Paul A

Development of a genetic priority score to predict drug side effects using human genetic evidence

利用人类遗传证据开发预测药物副作用的遗传优先评分

Duffy, Áine; Chen, Robert; Stein, David; Park, Joshua K; Mort, Matthew; Verbanck, Marie; Schlessinger, Avner; Itan, Yuval; Cooper, David N; Jordan, Daniel M; Rocheleau, Ghislain; Do, Ron

Expanding the utility of variant effect predictions with phenotype-specific models

利用表型特异性模型扩展变异效应预测的实用性

Stein, David; Kars, Meltem Ece; Milisavljevic, Baptiste; Mort, Matthew; Stenson, Peter D; Casanova, Jean-Laurent; Cooper, David N; Boisson, Bertrand; Zhang, Peng; Schlessinger, Avner; Itan, Yuval

Maternal medication use in pregnancy and offspring ASD risk: A prescription-wide, target-informed study

孕期母亲用药与后代自闭症谱系障碍风险:一项基于处方、以目标为导向的研究

Zaks, Nina; Kodesh, Arad; Zatorski, Nicole; Wang, Yifan; Levine, Stephen Z; Sandin, Sven; Reichenberg, Abraham; Schlessinger, Avner; Janecka, Magdalena

Capturing Unanticipated Drug Toxicities Using an Ensemble Machine Learning Approach

利用集成机器学习方法捕捉意外药物毒性

Zatorski, Nicole; Schlessinger, Avner

Genetic evidence informs the direction of therapeutic modulation in drug development

遗传证据为药物研发中的治疗调控方向提供了指导。

Chen, Robert; Duffy, Áine; Park, Joshua K; Stein, David; Schlessinger, Avner; Itan, Yuval; Glicksberg, Benjamin S; Tinker, Rory J; Jordan, Daniel M; Rocheleau, Ghislain; Do, Ron

Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications

针对 19,365 个基因和 399 种药物适应症,开发了一种基于人类遗传学的优先评分系统

Duffy, Áine; Petrazzini, Ben Omega; Stein, David; Park, Joshua K; Forrest, Iain S; Gibson, Kyle; Vy, Ha My; Chen, Robert; Márquez-Luna, Carla; Mort, Matthew; Verbanck, Marie; Schlessinger, Avner; Itan, Yuval; Cooper, David N; Rocheleau, Ghislain; Jordan, Daniel M; Do, Ron

Expanding drug targets for 112 chronic diseases using a machine learning-assisted genetic priority score

利用机器学习辅助的基因优先评分,拓展112种慢性疾病的药物靶点

Chen, Robert; Duffy, Áine; Petrazzini, Ben O; Vy, Ha My; Stein, David; Mort, Matthew; Park, Joshua K; Schlessinger, Avner; Itan, Yuval; Cooper, David N; Jordan, Daniel M; Rocheleau, Ghislain; Do, Ron

Haploinsufficiency underlies the neurodevelopmental consequences of SLC6A1 variants

单倍体不足是SLC6A1变异导致神经发育后果的根本原因。

Silva, Dina Buitrago; Trinidad, Marena; Ljungdahl, Alicia; Revalde, Jezrael L; Berguig, Geoffrey Y; Wallace, William; Patrick, Cory S; Bomba, Lorenzo; Arkin, Michelle; Dong, Shan; Estrada, Karol; Hutchinson, Keino; LeBowitz, Jonathan H; Schlessinger, Avner; Johannesen, Katrine M; Møller, Rikke S; Giacomini, Kathleen M; Froelich, Steven; Sanders, Stephan J; Wuster, Arthur

Comprehensive Characterization of LAT1 Cholesterol-Binding Sites

LAT1胆固醇结合位点的全面表征

Hutchinson, Keino; Schlessinger, Avner