日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Impact of antibody Fc engineering on translational pharmacology, and safety: insights from industry case studies

抗体Fc工程对转化药理学和安全性的影响:来自行业案例研究的启示

Brennan, Frank R; Polli, J Ryan; Sathish, Jean; Ramones, Melissa; Wolf, Babette; Schlothauer, Tilman; Peters, Shirley J; Maier, Curtis C; Ji, Changhua; Wensel, David L; Witcher, Derrick; Ryan, Patricia C; Manetz, T Scott; Flora, Adriano; Soper, Brian; Fogal, Birgit; Dzielak, Lindsey; Wang, Xiaoting; Shastri, Prathap Nagaraja; Price, Karen; Doyle, Michael; Sharda, Nidhi; Struthers, Mary; Brinkhaus, Maximilian; Balbino, Bianca; Stefanich, Eric; Honda, Masaki; Andersen, Jan Terje; Mitchell-Ryan, Shermaine; Humphreys, David P

Enhanced plasma half-life and efficacy of engineered human albumin-fused GLP-1 despite enzymatic cleavage of its C-terminal end.

尽管工程化人血白蛋白融合的 GLP-1 的 C 端被酶切,但其血浆半衰期和疗效仍得到增强

Nilsen Jeannette, Aaen Kristin Hovden, Benjakul Sopisa, Ruso-Julve Fulgencio, Greiner Thomas Uwe, Bejan Daniela, Stensland Maria, Singh Sachin, Schlothauer Tilman, Sandlie Inger, Andersen Jan Terje

Soft Tissue Changes at the Pontic Sites of Cantilever Zirconia Ceramic Resin-Bonded Fixed Dental Protheses in the Esthetic Zone: A Clinical Observational Study

美学区悬臂式氧化锆陶瓷树脂粘接固定义齿桥体部位软组织变化:一项临床观察研究

Türp, Lisa; Schlothauer, Theresia; Yazigi, Christine; Kern, Matthias

Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

人IgG Fc工程改造可增强血浆半衰期、黏膜分布并杀灭癌细胞和细菌

Stian Foss ,Siri A Sakya # ,Leire Aguinagalde # ,Marta Lustig # ,Jutamas Shaughnessy # ,Ana Rita Cruz # ,Lisette Scheepmaker # ,Line Mathiesen ,Fulgencio Ruso-Julve ,Aina Karen Anthi ,Torleif Tollefsrud Gjølberg ,Simone Mester ,Malin Bern ,Mitchell Evers ,Diane B Bratlie ,Terje E Michaelsen ,Tilman Schlothauer ,Devin Sok ,Jayanta Bhattacharya ,Jeanette Leusen ,Thomas Valerius ,Sanjay Ram ,Suzan H M Rooijakkers ,Inger Sandlie ,Jan Terje Andersen

TRIM21 and Fc-engineered antibodies: decoding its complex antibody binding mode with implications for viral neutralization

TRIM21 和 Fc 工程抗体:解码其复杂的抗体结合模式对病毒中和的影响

Johannes Reusch, Linda Elise Franken, Jakob Then, Philippe Ringler, Joachim Butzer, Thomas Juroschek, Christian Klein, Tilman Schlothauer, Laurent Larivière

Benchmarking glycoform-resolved affinity separation - mass spectrometry assays for studying FcγRIIIa binding

糖型解析亲和分离基准测试 - 用于研究 FcγRIIIa 结合的质谱分析

Christoph Gstöttner, Steffen Lippold, Michaela Hook, Feng Yang, Markus Haberger, Manfred Wuhrer, David Falck, Tilman Schlothauer, Elena Domínguez-Vega

Insight into the avidity-affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn

深入了解 IgG 和 FcRn 之间二价 pH 依赖性相互作用的亲和力-亲和力关系

Johannes Reusch, Jan Terje Andersen, Ulrich Rant, Tilman Schlothauer

Perinatal outcome of immigrant women with and without refugee status compared to non-immigrant women: results of the pregnancy and obstetric care for refugees (PROREF) cross-sectional study

移民妇女(无论是否具有难民身份)与非移民妇女的围产期结局比较:难民妊娠和产科保健(PROREF)横断面研究的结果

Schlothauer, Darja; Teschemacher, Louise; Breckenkamp, Jürgen; Borde, Theda; David, Matthias; Abou-Dakn, Michael; Henrich, Wolfgang; Seidel, Vera

Function-structure approach reveals novel insights on the interplay of Immunoglobulin G 1 proteoforms and Fc gamma receptor IIa allotypes

功能结构方法揭示了免疫球蛋白 G1 蛋白形式与 Fc γ 受体 IIa 同种型相互作用的新见解

Steffen Lippold, Karishma Mistry, Sunidhi Lenka, Kevin Whang, Peilu Liu, Sebastian Pitschi, Felix Kuhne, Dietmar Reusch, Lance Cadang, Alexander Knaupp, Saeed Izadi, Alexis Dunkle, Feng Yang, Tilman Schlothauer

Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans

将 Brainshuttle™ 淀粉样β抗体融合蛋白 trontinemab 递送至非人类灵长类动物脑部,并预计在人类中有效剂量方案

Hans Peter Grimm, Vanessa Schumacher, Martin Schäfer, Sabine Imhof-Jung, Per-Ola Freskgård, Kevin Brady, Carsten Hofmann, Petra Rüger, Tilman Schlothauer, Ulrich Göpfert, Maximilian Hartl, Sylvia Rottach, Adrian Zwick, Shanon Seger, Rachel Neff, Jens Niewoehner, Niels Janssen