日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Hyperactivity in Mice Induced by Opioid Agonists with Partial Intrinsic Efficacy and Biased Agonism Administered Alone and in Combination with Morphine

单独使用或与吗啡联合使用具有部分内在效力和偏向性激动作用的阿片类激动剂可诱导小鼠出现多动症

Acevedo-Canabal, Agnes; Grim, Travis W; Schmid, Cullen L; McFague, Nina; Stahl, Edward L; Kennedy, Nicole M; Bannister, Thomas D; Bohn, Laura M

Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain

在小鼠疼痛模型中比较吗啡、羟考酮和偏向性MOR激动剂SR-17018的耐受性和疗效

Pantouli, Fani; Grim, Travis W; Schmid, Cullen L; Acevedo-Canabal, Agnes; Kennedy, Nicole M; Cameron, Michael D; Bannister, Thomas D; Bohn, Laura M

Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias

优化一系列具有高G蛋白信号偏向性的μ阿片受体(MOR)激动剂

Kennedy, Nicole M; Schmid, Cullen L; Ross, Nicolette C; Lovell, Kimberly M; Yue, Zhizhou; Chen, Yen Ting; Cameron, Michael D; Bohn, Laura M; Bannister, Thomas D

G protein signaling-biased agonism at the κ-opioid receptor is maintained in striatal neurons.

纹状体神经元中维持着γ-阿片受体的G蛋白信号偏向激动作用

Ho Jo-Hao, Stahl Edward L, Schmid Cullen L, Scarry Sarah M, Aubé Jeffrey, Bohn Laura M

The effect of quinine in two bottle choice procedures in C57BL6 mice: Opioid preference, somatic withdrawal, and pharmacokinetic outcomes

奎宁对C57BL6小鼠两种瓶子选择实验的影响:阿片类药物偏好、躯体戒断反应和药代动力学结果

Grim, Travis W; Park, Scarlet Jinhong; Schmid, Cullen L; Laprairie, Robert B; Cameron, Michael; Bohn, Laura M

Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ-OR Agonist

动态战略键分析得出强效κ-阿片受体激动剂20-去甲-萨尔维诺林A的十步合成路线

Roach, Jeremy J; Sasano, Yusuke; Schmid, Cullen L; Zaidi, Saheem; Katritch, Vsevolod; Stevens, Raymond C; Bohn, Laura M; Shenvi, Ryan A

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

κ阿片受体的偏向性激动剂可抑制疼痛和瘙痒,而不会引起镇静或烦躁不安。

Brust, Tarsis F; Morgenweck, Jenny; Kim, Susy A; Rose, Jamie H; Locke, Jason L; Schmid, Cullen L; Zhou, Lei; Stahl, Edward L; Cameron, Michael D; Scarry, Sarah M; Aubé, Jeffrey; Jones, Sara R; Martin, Thomas J; Bohn, Laura M

Clozapine acts as an agonist at serotonin 2A receptors to counter MK-801-induced behaviors through a βarrestin2-independent activation of Akt

氯氮平作为5-羟色胺2A受体激动剂,通过不依赖于β-arrestin2的Akt激活作用,拮抗MK-801诱导的行为。

Schmid, Cullen L; Streicher, John M; Meltzer, Herbert Y; Bohn, Laura M

Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons

6'-胍基吲哚(6'-GNTI)对纹状体神经元κ-阿片受体的功能选择性

Schmid, Cullen L; Streicher, John M; Groer, Chad E; Munro, Thomas A; Zhou, Lei; Bohn, Laura M

β-arrestin2 regulates cannabinoid CB1 receptor signaling and adaptation in a central nervous system region-dependent manner

β-arrestin2 以中枢神经系统区域依赖的方式调节大麻素 CB1 受体信号传导和适应性。

Nguyen, Peter T; Schmid, Cullen L; Raehal, Kirsten M; Selley, Dana E; Bohn, Laura M; Sim-Selley, Laura J