日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Treatment of a metabolic liver disease in mice with a transient prime editing approach

利用瞬时启动子编辑方法治疗小鼠代谢性肝病

Tanja Rothgangl # ,András Tálas # ,Eleonora I Ioannidi # ,Yanik Weber ,Desirée Böck ,Mai Matsushita ,Elina Andrea Villiger ,Lukas Schmidheini ,Woohyun J Moon ,Paulo J C Lin ,Steven H Y Fan ,Kim F Marquart ,Cornelia Schwerdel ,Nicole Rimann ,Erica Faccin ,Lukas Villiger ,Hiromi Muramatsu ,Máté Vadovics ,Alessio Cremonesi ,Péter István Kulcsár ,Beat Thöny ,Manfred Kopf ,Johannes Häberle ,Norbert Pardi ,Ying K Tam ,Gerald Schwank

Prime editing of the β(1) adrenoceptor in the brain restores physiological REM sleep in a mouse model of Alzheimer's disease.

对大脑中β(1)肾上腺素受体进行原始编辑,可恢复阿尔茨海默病小鼠模型的生理性快速眼动睡眠。

Böck Desirée, Tidecks Lisa, Wilhelm Maria, ElGrawani Waleed, Duss Sian, Trevisan Chiara, Vena Dalila, Reuss Anna Maria, Kissling Lucas, Ranucci Matteo, Privitera Mattia, Polzer Lisa K, Economides Athena E, Ioannidi Eleonora I, Mendes Raquel, Weber Yanik, Leonardi Justine, Mumenthaler Jonas, Villiger Elina, Goutagny Romain, Mathis Chantal, Schmidheini Lukas, Rothgangl Tanja, Janjuha Sharan, Patriarchi Tommaso, Bohacek Johannes, Sych Yaroslav, Aguzzi Adriano, Winterer Jochen, Kompotis Konstantinos, Schwank Gerald

Machine learning prediction of prime editing efficiency across diverse chromatin contexts

利用机器学习预测不同染色质环境下的酶促编辑效率

Mathis, Nicolas; Allam, Ahmed; Tálas, András; Kissling, Lucas; Benvenuto, Elena; Schmidheini, Lukas; Schep, Ruben; Damodharan, Tanav; Balázs, Zsolt; Janjuha, Sharan; Ioannidi, Eleonora I; Böck, Desirée; van Steensel, Bas; Krauthammer, Michael; Schwank, Gerald

Effective genome editing with an enhanced ISDra2 TnpB system and deep learning-predicted ωRNAs.

利用增强型 ISDra2 TnpB 系统和深度学习预测的 αRNA 进行有效的基因组编辑

Marquart Kim Fabiano, Mathis Nicolas, Mollaysa Amina, Müller Saphira, Kissling Lucas, Rothgangl Tanja, Schmidheini Lukas, Kulcsár Péter István, Allam Ahmed, Kaufmann Masako M, Matsushita Mai, Haenggi Tatjana, Cathomen Toni, Kopf Manfred, Krauthammer Michael, Schwank Gerald

Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility

具有广泛 PAM 兼容性的紧凑型 CjCas9 变体的连续定向进化

Lukas Schmidheini, Nicolas Mathis, Kim Fabiano Marquart, Tanja Rothgangl, Lucas Kissling, Desirée Böck, Christelle Chanez, Jingrui Priscilla Wang, Martin Jinek, Gerald Schwank

Predicting prime editing efficiency and product purity by deep learning

通过深度学习预测主要编辑效率和产品纯度

Nicolas Mathis #, Ahmed Allam #, Lucas Kissling, Kim Fabiano Marquart, Lukas Schmidheini, Cristina Solari, Zsolt Balázs, Michael Krauthammer, Gerald Schwank

In vivo prime editing of a metabolic liver disease in mice

小鼠体内代谢性肝病的早期编辑

Desirée Böck ,Tanja Rothgangl ,Lukas Villiger ,Lukas Schmidheini ,Mai Matsushita ,Nicolas Mathis ,Eleonora Ioannidi ,Nicole Rimann ,Hiu Man Grisch-Chan ,Susanne Kreutzer ,Zacharias Kontarakis ,Manfred Kopf ,Beat Thöny ,Gerald Schwank

Self-Assembly of Nanodiamonds and Plasmonic Nanoparticles for Nanoscopy

纳米金刚石和等离子体纳米粒子的自组装用于纳米显微镜

Schmidheini, Lukas; Tiefenauer, Raphael F; Gatterdam, Volker; Frutiger, Andreas; Sannomiya, Takumi; Aramesh, Morteza

Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope

用脱氨酶替换 SpCas9 的 HNH 结构域可生成具有不同靶向范围的紧凑型碱基编辑器

Villiger, Lukas; Schmidheini, Lukas; Mathis, Nicolas; Rothgangl, Tanja; Marquart, Kim; Schwank, Gerald