日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural Diversification of 14-Membered Macrolides by Chemoenzymatic Synthesis

通过化学酶法合成实现14元大环内酯的结构多样化

Curtis, Brian J; Boesger, Hannah A; Schmidt, Jennifer J; Adrover-Castellano, Maria L; Momin, Areeba N; Glasser, Carolyn A; Sherman, David H

Directed Evolution of a Modular Polyketide Synthase Thioesterase for Generation of a Hybrid Macrocyclic Ring System

利用模块化聚酮合酶硫酯酶定向进化生成杂化大环体系

Adrover-Castellano, Maria L; Curtis, Brian J; Schmidt, Jennifer J; Boesger, Hannah A; Glasser, Carolyn A; Olukorede, Damilola E; Qu, Fengrui; Sherman, David H

Chemoenzymatic synthesis of fluorinated polyketides

氟化聚酮化合物的化学酶法合成

Rittner, Alexander; Joppe, Mirko; Schmidt, Jennifer J; Mayer, Lara Maria; Reiners, Simon; Heid, Elia; Herzberg, Dietmar; Sherman, David H; Grininger, Martin

Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase

模块化聚酮合酶酰基转移酶中底物选择性基序的计算引导交换

Kalkreuter, Edward; Bingham, Kyle S; Keeler, Aaron M; Lowell, Andrew N; Schmidt, Jennifer J; Sherman, David H; Williams, Gavin J

Engineering P450 TamI as an Iterative Biocatalyst for Selective Late-Stage C-H Functionalization and Epoxidation of Tirandamycin Antibiotics

工程化P450 TamI作为迭代生物催化剂用于选择性后期CH官能化和环氧化替兰霉素抗生素

Espinoza, Rosa V; Haatveit, Kersti Caddell; Grossman, S Wald; Tan, Jin Yi; McGlade, Caylie A; Khatri, Yogan; Newmister, Sean A; Schmidt, Jennifer J; Garcia-Borràs, Marc; Montgomery, John; Houk, K N; Sherman, David H

Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida.

对来自灰红小单孢菌的 16 元大环内酯类抗生素——霉素的核糖体结合和抗菌研究

Breiner-Goldstein Elinor, Eyal Zohar, Matzov Donna, Halfon Yehuda, Cimicata Giuseppe, Baum Moti, Rokney Assaf, Ezernitchi Analia V, Lowell Andrew N, Schmidt Jennifer J, Rozenberg Haim, Zimmerman Ella, Bashan Anat, Valinsky Lea, Anzai Yojiro, Sherman David H, Yonath Ada

Biosynthetic Cyclization Catalysts for the Assembly of Peptide and Polyketide Natural Products

用于肽和聚酮类天然产物组装的生物合成环化催化剂

Adrover-Castellano, Maria L; Schmidt, Jennifer J; Sherman, David H

Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases

通过杂合聚酮合酶探索选择性并创造结构多样性

Koch, Aaron A; Schmidt, Jennifer J; Lowell, Andrew N; Hansen, Douglas A; Coburn, Katherine M; Chemler, Joseph A; Sherman, David H

A Versatile Chemoenzymatic Synthesis for the Discovery of Potent Cryptophycin Analogs

一种用于发现高效隐藻素类似物的多功能化学酶法合成

Schmidt, Jennifer J; Khatri, Yogan; Brody, Scott I; Zhu, Catherine; Pietraszkiewicz, Halina; Valeriote, Frederick A; Sherman, David H