日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Library Screening, In Vivo Confirmation, and Structural and Bioinformatic Analysis of Pentapeptide Sequences as Substrates for Protein Farnesyltransferase

五肽序列作为蛋白质法尼基转移酶底物的文库筛选、体内验证、结构和生物信息学分析

Schey, Garrett L; Hildebrandt, Emily R; Wang, You; Diwan, Safwan; Passetti, Holly A; Potts, Gavin W; Sprague-Getsy, Andrea M; Leoni, Ethan R; Kuebler, Taylor S; Sham, Yuk Y; Hougland, James L; Beese, Lorena S; Schmidt, Walter K; Distefano, Mark D

Targeted genetic and small molecule disruption of N-Ras CaaX cleavage alters its localization and oncogenic potential.

通过靶向基因和小分子手段破坏 N-Ras CaaX 的切割,可以改变其定位和致癌潜力

Hildebrandt Emily R, Hussain Shaneela A, Sieburg Michelle A, Ravishankar Rajani, Asad Nadeem, Gore Sangram, Ito Takahiro, Hougland James L, Dore Timothy M, Schmidt Walter K

A comprehensive in vivo screen of yeast farnesyltransferase activity reveals broad reactivity across a majority of CXXX sequences

对酵母法尼基转移酶活性的全面体内筛选表明,其对大多数CXXX序列具有广泛的反应性。

Kim, June H; Hildebrandt, Emily R; Sarkar, Anushka; Yeung, Wayland; Waldon, La Ryel A; Kannan, Natarajan; Schmidt, Walter K

MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase

MALDI-MS分析肽库拓展了法尼基转移酶的底物范围

Schey, Garrett L; Buttery, Peter H; Hildebrandt, Emily R; Novak, Sadie X; Schmidt, Walter K; Hougland, James L; Distefano, Mark D

Protein Farnesyltransferase Catalyzes Unanticipated Farnesylation and Geranylgeranylation of Shortened Target Sequences

蛋白质法尼基转移酶催化缩短靶序列的非预期法尼基化和香叶基香叶基化

Ashok, Sudhat; Hildebrandt, Emily R; Ruiz, Colby S; Hardgrove, Daniel S; Coreno, David W; Schmidt, Walter K; Hougland, James L

Rce1: mechanism and inhibition

Rce1:机制和抑制

Hampton, Shahienaz E; Dore, Timothy M; Schmidt, Walter K

Efficient farnesylation of an extended C-terminal C(x)(3)X sequence motif expands the scope of the prenylated proteome

高效的法尼基化修饰延伸的C端C(x)(3)X序列基序,扩展了异戊二烯化蛋白质组的范围。

Blanden, Melanie J; Suazo, Kiall F; Hildebrandt, Emily R; Hardgrove, Daniel S; Patel, Meet; Saunders, William P; Distefano, Mark D; Schmidt, Walter K; Hougland, James L

8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells.

8-羟基喹啉类 Rce1 蛋白酶抑制剂会破坏人类细胞中 Ras 的膜定位

Mohammed Idrees, Hampton Shahienaz E, Ashall Louise, Hildebrandt Emily R, Kutlik Robert A, Manandhar Surya P, Floyd Brandon J, Smith Haley E, Dozier Jonathan K, Distefano Mark D, Schmidt Walter K, Dore Timothy M

Topology of the yeast Ras converting enzyme as inferred from cysteine accessibility studies

根据半胱氨酸可及性研究推断酵母Ras转化酶的拓扑结构

Hildebrandt, Emily R; Davis, Dillon M; Deaton, John; Krishnankutty, Ranjith K; Lilla, Edward; Schmidt, Walter K

Cell-permeable, small-molecule activators of the insulin-degrading enzyme.

细胞可渗透的小分子胰岛素降解酶激活剂

Kukday Sayali S, Manandhar Surya P, Ludley Marissa C, Burriss Mary E, Alper Benjamin J, Schmidt Walter K