日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Evaluation of circulating tumor DNA as a prognostic and predictive biomarker in BRAF V600E mutated colorectal cancer-results from the FIRE-4.5 study

评估循环肿瘤DNA作为BRAF V600E突变型结直肠癌的预后和预测生物标志物——FIRE-4.5研究结果

Klein-Scory, Susanne; Baraniskin, Alexander; Schmiegel, Wolff; Mika, Thomas; Schroers, Roland; Held, Swantje; Heinrich, Kathrin; Tougeron, David; Modest, Dominik P; Schwaner, Ingo; Eucker, Jan; Pihusch, Rudolf; Stauch, Martina; Kaiser, Florian; Kahl, Christoph; Karthaus, Meinolf; Müller, Christian; Burkart, Christof; Stintzing, Sebastian; Heinemann, Volker

An AI-Based Clinical Decision Support System for Antibiotic Therapy in Sepsis (KINBIOTICS): Use Case Analysis

基于人工智能的脓毒症抗生素治疗临床决策支持系统(KINBIOTICS):用例分析

Düvel, Juliane Andrea; Lampe, David; Kirchner, Maren; Elkenkamp, Svenja; Cimiano, Philipp; Düsing, Christoph; Marchi, Hannah; Schmiegel, Sophie; Fuchs, Christiane; Claßen, Simon; Meier, Kirsten-Laura; Borgstedt, Rainer; Rehberg, Sebastian; Greiner, Wolfgang

Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription

拓扑异构酶1和BRD4介导的暂停释放的共同抑制可通过通读转录选择性地杀死胰腺癌细胞。

Donald P Cameron ,Jan Grosser ,Swetlana Ladigan ,Vladislav Kuzin ,Evanthia Iliopoulou ,Anika Wiegard ,Hajar Benredjem ,Kathryn Jackson ,Sven T Liffers ,Smiths Lueong ,Phyllis F Cheung ,Deepak Vangala ,Michael Pohl ,Richard Viebahn ,Christian Teschendorf ,Heiner Wolters ,Selami Usta ,Keyi Geng ,Claudia Kutter ,Marie Arsenian-Henriksson ,Jens T Siveke ,Andrea Tannapfel ,Wolff Schmiegel ,Stephan A Hahn ,Laura Baranello

Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database

携带致病性错配修复基因变异并接受早期癌症诊断和治疗监测的患者的年龄、基因和性别死亡率:来自前瞻性林奇综合征数据库的报告

Dominguez-Valentin, Mev; Haupt, Saskia; Seppälä, Toni T; Sampson, Julian R; Sunde, Lone; Bernstein, Inge; Jenkins, Mark A; Engel, Christoph; Aretz, Stefan; Nielsen, Maartje; Capella, Gabriel; Balaguer, Francesc; Evans, Dafydd Gareth; Burn, John; Holinski-Feder, Elke; Bertario, Lucio; Bonanni, Bernardo; Lindblom, Annika; Levi, Zohar; Macrae, Finlay; Winship, Ingrid; Plazzer, John-Paul; Sijmons, Rolf; Laghi, Luigi; Della Valle, Adriana; Heinimann, Karl; Dębniak, Tadeusz; Fruscio, Robert; Lopez-Koestner, Francisco; Alvarez-Valenzuela, Karin; Katz, Lior H; Laish, Ido; Vainer, Elez; Vaccaro, Carlos; Carraro, Dirce Maria; Monahan, Kevin; Half, Elizabeth; Stakelum, Aine; Winter, Des; Kennelly, Rory; Gluck, Nathan; Sheth, Harsh; Abu-Freha, Naim; Greenblatt, Marc; Rossi, Benedito Mauro; Bohorquez, Mabel; Cavestro, Giulia Martina; Lino-Silva, Leonardo S; Horisberger, Karoline; Tibiletti, Maria Grazia; Nascimento, Ivana do; Thomas, Huw; Rossi, Norma Teresa; Apolinário da Silva, Leandro; Zaránd, Attila; Ruiz-Bañobre, Juan; Heuveline, Vincent; Mecklin, Jukka-Pekka; Pylvänäinen, Kirsi; Renkonen-Sinisalo, Laura; Lepistö, Anna; Peltomäki, Päivi; Therkildsen, Christina; Madsen, Mia Gebauer; Burgdorf, Stefan Kobbelgaard; Hopper, John L; Win, Aung Ko; Haile, Robert W; Lindor, Noralane; Gallinger, Steven; Le Marchand, Loïc; Newcomb, Polly A; Figueiredo, Jane; Buchanan, Daniel D; Thibodeau, Stephen N; von Knebel Doeberitz, Magnus; Loeffler, Markus; Rahner, Nils; Schröck, Evelin; Steinke-Lange, Verena; Schmiegel, Wolff; Vangala, Deepak; Perne, Claudia; Hüneburg, Robert; Redler, Silke; Büttner, Reinhard; Weitz, Jürgen; Pineda, Marta; Duenas, Nuria; Vidal, Joan Brunet; Moreira, Leticia; Sánchez, Ariadna; Hovig, Eivind; Nakken, Sigve; Green, Kate; Lalloo, Fiona; Hill, James; Crosbie, Emma; Mints, Miriam; Goldberg, Yael; Tjandra, Douglas; Ten Broeke, Sanne W; Kariv, Revital; Rosner, Guy; Advani, Suresh H; Thomas, Lidiya; Shah, Pankaj; Shah, Mithun; Neffa, Florencia; Esperon, Patricia; Pavicic, Walter; Torrezan, Giovana Tardin; Bassaneze, Thiago; Martin, Claudia Alejandra; Moslein, Gabriela; Moller, Pål

Lasting response by vertical inhibition with cetuximab and trametinib in KRAS-mutated colorectal cancer patient-derived xenografts

在KRAS突变型结直肠癌患者来源的异种移植模型中,西妥昔单抗和曲美替尼通过垂直抑制作用产生持久疗效

Timm M Reissig ,Swetlana Ladigan-Badura ,Anja Steinberg ,Abdelouahid Maghnouj ,Ting Li ,Berlinda Verdoodt ,Sven T Liffers ,Michael Pohl ,Heiner Wolters ,Christian Teschendorf ,Richard Viebahn ,Jakob Admard ,Nicolas Casadei ,Andrea Tannapfel ,Wolff Schmiegel ,Stephan A Hahn ,Deepak B Vangala

Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

林奇综合征患者结直肠癌发病率:前瞻性林奇综合征数据库与国际错配修复联盟结果的比较

Møller, Pål; Seppälä, Toni; Dowty, James G; Haupt, Saskia; Dominguez-Valentin, Mev; Sunde, Lone; Bernstein, Inge; Engel, Christoph; Aretz, Stefan; Nielsen, Maartje; Capella, Gabriel; Evans, Dafydd Gareth; Burn, John; Holinski-Feder, Elke; Bertario, Lucio; Bonanni, Bernardo; Lindblom, Annika; Levi, Zohar; Macrae, Finlay; Winship, Ingrid; Plazzer, John-Paul; Sijmons, Rolf; Laghi, Luigi; Valle, Adriana Della; Heinimann, Karl; Half, Elizabeth; Lopez-Koestner, Francisco; Alvarez-Valenzuela, Karin; Scott, Rodney J; Katz, Lior; Laish, Ido; Vainer, Elez; Vaccaro, Carlos Alberto; Carraro, Dirce Maria; Gluck, Nathan; Abu-Freha, Naim; Stakelum, Aine; Kennelly, Rory; Winter, Des; Rossi, Benedito Mauro; Greenblatt, Marc; Bohorquez, Mabel; Sheth, Harsh; Tibiletti, Maria Grazia; Lino-Silva, Leonardo S; Horisberger, Karoline; Portenkirchner, Carmen; Nascimento, Ivana; Rossi, Norma Teresa; da Silva, Leandro Apolinário; Thomas, Huw; Zaránd, Attila; Mecklin, Jukka-Pekka; Pylvänäinen, Kirsi; Renkonen-Sinisalo, Laura; Lepisto, Anna; Peltomäki, Päivi; Therkildsen, Christina; Lindberg, Lars Joachim; Thorlacius-Ussing, Ole; von Knebel Doeberitz, Magnus; Loeffler, Markus; Rahner, Nils; Steinke-Lange, Verena; Schmiegel, Wolff; Vangala, Deepak; Perne, Claudia; Hüneburg, Robert; de Vargas, Aída Falcón; Latchford, Andrew; Gerdes, Anne-Marie; Backman, Ann-Sofie; Guillén-Ponce, Carmen; Snyder, Carrie; Lautrup, Charlotte K; Amor, David; Palmero, Edenir; Stoffel, Elena; Duijkers, Floor; Hall, Michael J; Hampel, Heather; Williams, Heinric; Okkels, Henrik; Lubiński, Jan; Reece, Jeanette; Ngeow, Joanne; Guillem, Jose G; Arnold, Julie; Wadt, Karin; Monahan, Kevin; Senter, Leigha; Rasmussen, Lene J; van Hest, Liselotte P; Ricciardiello, Luigi; Kohonen-Corish, Maija R J; Ligtenberg, Marjolijn J L; Southey, Melissa; Aronson, Melyssa; Zahary, Mohd N; Samadder, N Jewel; Poplawski, Nicola; Hoogerbrugge, Nicoline; Morrison, Patrick J; James, Paul; Lee, Grant; Chen-Shtoyerman, Rakefet; Ankathil, Ravindran; Pai, Rish; Ward, Robyn; Parry, Susan; Dębniak, Tadeusz; John, Thomas; van Overeem Hansen, Thomas; Caldés, Trinidad; Yamaguchi, Tatsuro; Barca-Tierno, Verónica; Garre, Pilar; Cavestro, Giulia Martina; Weitz, Jürgen; Redler, Silke; Büttner, Reinhard; Heuveline, Vincent; Hopper, John L; Win, Aung Ko; Lindor, Noralane; Gallinger, Steven; Le Marchand, Loïc; Newcomb, Polly A; Figueiredo, Jane; Buchanan, Daniel D; Thibodeau, Stephen N; Ten Broeke, Sanne W; Hovig, Eivind; Nakken, Sigve; Pineda, Marta; Dueñas, Nuria; Brunet, Joan; Green, Kate; Lalloo, Fiona; Newton, Katie; Crosbie, Emma J; Mints, Miriam; Tjandra, Douglas; Neffa, Florencia; Esperon, Patricia; Kariv, Revital; Rosner, Guy; Pavicic, Walter Hernán; Kalfayan, Pablo; Torrezan, Giovana Tardin; Bassaneze, Thiago; Martin, Claudia; Moslein, Gabriela; Ahadova, Aysel; Kloor, Matthias; Sampson, Julian R; Jenkins, Mark A

Secondary resistance to anti-EGFR therapy by transcriptional reprogramming in patient-derived colorectal cancer models

患者来源的结直肠癌模型中,转录重编程导致对EGFR抑制剂治疗的继发性耐药

Deepak Vangala # ,Swetlana Ladigan # ,Sven T Liffers ,Soha Noseir ,Abdelouahid Maghnouj ,Tina-Maria Götze ,Berlinda Verdoodt ,Susanne Klein-Scory ,Laura Godfrey ,Martina K Zowada ,Mario Huerta ,Daniel L Edelstein ,Jaime Martinez de Villarreal ,Miriam Marqués ,Jörg Kumbrink ,Andreas Jung ,Tobias Schiergens ,Jens Werner ,Volker Heinemann ,Sebastian Stintzing ,Doris Lindoerfer ,Ulrich Mansmann ,Michael Pohl ,Christian Teschendorf ,Christiane Bernhardt ,Heiner Wolters ,Josef Stern ,Selami Usta ,Richard Viebahn ,Jacob Admard ,Nicolas Casadei ,Stefan Fröhling ,Claudia R Ball ,Jens T Siveke ,Hanno Glimm ,Andrea Tannapfel ,Wolff Schmiegel ,Stephan A Hahn

Uptake of hysterectomy and bilateral salpingo-oophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report

致病性错配修复变异携带者子宫切除术和双侧输卵管卵巢切除术的接受情况:一项前瞻性林奇综合征数据库报告

Seppälä, Toni T; Dominguez-Valentin, Mev; Crosbie, Emma J; Engel, Christoph; Aretz, Stefan; Macrae, Finlay; Winship, Ingrid; Capella, Gabriel; Thomas, Huw; Hovig, Eivind; Nielsen, Maartje; Sijmons, Rolf H; Bertario, Lucio; Bonanni, Bernardo; Tibiletti, Maria G; Cavestro, Giulia M; Mints, Miriam; Gluck, Nathan; Katz, Lior; Heinimann, Karl; Vaccaro, Carlos A; Green, Kate; Lalloo, Fiona; Hill, James; Schmiegel, Wolff; Vangala, Deepak; Perne, Claudia; Strauß, Hans-Georg; Tecklenburg, Johanna; Holinski-Feder, Elke; Steinke-Lange, Verena; Mecklin, Jukka-Pekka; Plazzer, John-Paul; Pineda, Marta; Navarro, Matilde; Vida, Joan B; Kariv, Revital; Rosner, Guy; Piñero, Tamara A; Pavicic, Walter; Kalfayan, Pablo; Ten Broeke, Sanne W; Jenkins, Mark A; Sunde, Lone; Bernstein, Inge; Burn, John; Greenblatt, Marc; de Vos Tot Nederveen Cappel, Wouter H; Della Valle, Adriana; Lopez-Koestner, Francisco; Alvarez, Karin; Büttner, Reinhard; Görgens, Heike; Morak, Monika; Holzapfel, Stefanie; Hüneburg, Robert; von Knebel Doeberitz, Magnus; Loeffler, Markus; Redler, Silke; Weitz, Jürgen; Pylvänäinen, Kirsi; Renkonen-Sinisalo, Laura; Lepistö, Anna; Hopper, John L; Win, Aung K; Lindor, Noralane M; Gallinger, Steven; Le Marchand, Loïc; Newcomb, Polly A; Figueiredo, Jane C; Thibodeau, Stephen N; Therkildsen, Christina; Wadt, Karin A W; Mourits, Marian J E; Ketabi, Zohreh; Denton, Oliver G; Rødland, Einar A; Vasen, Hans; Neffa, Florencia; Esperon, Patricia; Tjandra, Douglas; Möslein, Gabriela; Rokkones, Erik; Sampson, Julian R; Evans, D G; Møller, Pål

Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report

对致病性错配修复变异体女性杂合子进行风险降低性子宫切除术和双侧输卵管卵巢切除术:一项前瞻性林奇综合征数据库报告

Dominguez-Valentin, Mev; Crosbie, Emma J; Engel, Christoph; Aretz, Stefan; Macrae, Finlay; Winship, Ingrid; Capella, Gabriel; Thomas, Huw; Nakken, Sigve; Hovig, Eivind; Nielsen, Maartje; Sijmons, Rolf H; Bertario, Lucio; Bonanni, Bernardo; Tibiletti, Maria Grazia; Cavestro, Giulia Martina; Mints, Miriam; Gluck, Nathan; Katz, Lior; Heinimann, Karl; Vaccaro, Carlos A; Green, Kate; Lalloo, Fiona; Hill, James; Schmiegel, Wolff; Vangala, Deepak; Perne, Claudia; Strauß, Hans-Georg; Tecklenburg, Johanna; Holinski-Feder, Elke; Steinke-Lange, Verena; Mecklin, Jukka-Pekka; Plazzer, John-Paul; Pineda, Marta; Navarro, Matilde; Vidal, Joan Brunet; Kariv, Revital; Rosner, Guy; Piñero, Tamara Alejandra; Gonzalez, María Laura; Kalfayan, Pablo; Ryan, Neil; Ten Broeke, Sanne W; Jenkins, Mark A; Sunde, Lone; Bernstein, Inge; Burn, John; Greenblatt, Marc; de Vos Tot Nederveen Cappel, Wouter H; Della Valle, Adriana; Lopez-Koestner, Francisco; Alvarez, Karin; Büttner, Reinhard; Görgens, Heike; Morak, Monika; Holzapfel, Stefanie; Hüneburg, Robert; von Knebel Doeberitz, Magnus; Loeffler, Markus; Rahner, Nils; Weitz, Jürgen; Pylvänäinen, Kirsi; Renkonen-Sinisalo, Laura; Lepistö, Anna; Auranen, Annika; Hopper, John L; Win, Aung Ko; Haile, Robert W; Lindor, Noralane M; Gallinger, Steven; Le Marchand, Loïc; Newcomb, Polly A; Figueiredo, Jane C; Thibodeau, Stephen N; Therkildsen, Christina; Okkels, Henrik; Ketabi, Zohreh; Denton, Oliver G; Rødland, Einar Andreas; Vasen, Hans; Neffa, Florencia; Esperon, Patricia; Tjandra, Douglas; Möslein, Gabriela; Sampson, Julian R; Evans, D Gareth; Seppälä, Toni T; Møller, Pål

No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Database Study

MLH1和MSH2基因截断型致病变异与错义/异常剪接型致病变异的穿透率无差异:一项前瞻性林奇综合征数据库研究

Dominguez-Valentin, Mev; Plazzer, John-Paul; Sampson, Julian R; Engel, Christoph; Aretz, Stefan; Jenkins, Mark A; Sunde, Lone; Bernstein, Inge; Capella, Gabriel; Balaguer, Francesc; Macrae, Finlay; Winship, Ingrid M; Thomas, Huw; Evans, Dafydd Gareth; Burn, John; Greenblatt, Marc; de Vos Tot Nederveen Cappel, Wouter H; Sijmons, Rolf H; Nielsen, Maartje; Bertario, Lucio; Bonanni, Bernardo; Tibiletti, Maria Grazia; Cavestro, Giulia Martina; Lindblom, Annika; Valle, Adriana Della; Lopez-Kostner, Francisco; Alvarez, Karin; Gluck, Nathan; Katz, Lior; Heinimann, Karl; Vaccaro, Carlos A; Nakken, Sigve; Hovig, Eivind; Green, Kate; Lalloo, Fiona; Hill, James; Vasen, Hans F A; Perne, Claudia; Büttner, Reinhard; Görgens, Heike; Holinski-Feder, Elke; Morak, Monika; Holzapfel, Stefanie; Hüneburg, Robert; von Knebel Doeberitz, Magnus; Loeffler, Markus; Rahner, Nils; Weitz, Jürgen; Steinke-Lange, Verena; Schmiegel, Wolff; Vangala, Deepak; Crosbie, Emma J; Pineda, Marta; Navarro, Matilde; Brunet, Joan; Moreira, Leticia; Sánchez, Ariadna; Serra-Burriel, Miquel; Mints, Miriam; Kariv, Revital; Rosner, Guy; Piñero, Tamara Alejandra; Pavicic, Walter Hernán; Kalfayan, Pablo; Broeke, Sanne W Ten; Mecklin, Jukka-Pekka; Pylvänäinen, Kirsi; Renkonen-Sinisalo, Laura; Lepistö, Anna; Peltomäki, Päivi; Hopper, John L; Win, Aung Ko; Buchanan, Daniel D; Lindor, Noralane M; Gallinger, Steven; Marchand, Loïc Le; Newcomb, Polly A; Figueiredo, Jane C; Thibodeau, Stephen N; Therkildsen, Christina; Hansen, Thomas V O; Lindberg, Lars; Rødland, Einar Andreas; Neffa, Florencia; Esperon, Patricia; Tjandra, Douglas; Möslein, Gabriela; Seppälä, Toni T; Møller, Pål