日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GGC repeat expansions within new open reading frames are translated into toxic polyglycine proteins in oculopharyngodistal myopathy.

在眼咽远端肌病中,新的开放阅读框内的 GGC 重复扩增被翻译成有毒的聚甘氨酸蛋白。

Boivin Manon, Yu Jiaxi, Eura Nobuyuki, Schmitt Léa, Pietri David, Grandgirard Erwan, Goetz-Reiner Patrice, Plassard Damien, Nahy Chadia, Maglott Anne, Morlet Bastien, Gao Chao, Lefebvre Elise, Philipps Muriel, Eberling Pascal, Pichot Angélique, Rossolillo Paola, Thibault Christelle, Oulad-Abdelghani Mustapha, Nishino Ichizo, Yang Kang, Wang Ning, Wang Zhaoxia, Deng Jianwen, Charlet-Berguerand Nicolas

Bridging the Scales via Personalized Cellular Modeling and Deep Phenotyping in Schizophrenia

通过个性化细胞建模和深度表型分析弥合精神分裂症的鸿沟

Raabe, Florian J; Popovic, David; Vetter, Clara; Fischer, Laura E; Hasanaj, Genc; Karsli, Berkhan; Schäfer, Tim J; Almeida, Valeria; Atella, Alessia; Gagliardi, Miriam; Boudriot, Emanuel; Yakimov, Vladislav; Trastulla, Lucia; Jiang, Tengjia; Weyer, Clara; Roell, Lukas; Moussiopoulou, Joanna; Krcmár, Lenka; Galinski, Sabrina; Papazova, Irina; Pogarell, Oliver; Hasan, Alkomiet; Schulte, Eva C; Schmitt, Andrea; Koutsouleris, Nikolaos; Levina, Anna; Wagner, Elias; Rossner, Moritz J; Papiol, Sergi; Falkai, Peter; Keeser, Daniel; Ziller, Michael J

A human electrophysiological signature of Fragile X pathophysiology is shared in V1 of Fmr1(-/y) mice

Fmr1(-/y)小鼠的V1区与人类脆性X染色体综合征的病理生理特征相似。

Kornfeld-Sylla, Sara S; Gelegen, Cigdem; Norris, Jordan E; Chaloner, Francesca A; Lee, Maia; Khela, Michael; Heinrich, Maxwell J; Finnie, Peter S B; Ethridge, Lauren E; Erickson, Craig A; Schmitt, Lauren M; Cooke, Sam F; Wilkinson, Carol L; Bear, Mark F

Brain and neural cell type proteomics reveal extracellular matrix proteins enriched in progressive multiple sclerosis.

脑和神经细胞类型蛋白质组学揭示了进行性多发性硬化症中富集的细胞外基质蛋白。

Wang Henry, Pollock Niall M, Miranzadeh Mahabadi Hajar, Patel Jainilkumar, Moussa Eman W, Fernandes Jason P, Branton William G, Zhang Na, Elliott Cameron, Schmitt Laura, Power Christopher, Julien Olivier

A CD8αβ co-receptor modified to contain an intracellular CD28 signaling tail enhances TCR-engineered T cell function independent of solid-tumor-associated co-stimulatory ligands

经过修饰,含有胞内 CD28 信号尾的 CD8αβ 共受体可增强 TCR 工程化 T 细胞的功能,且该功能不依赖于实体瘤相关的共刺激配体。

Shihong Zhang #,Tzu-Hao Tang #,Sinéad Kinsella #,Francesco Mazziotta,Michael T Schweizer,Megan S McAfee,Ariunaa Munkhbat,Yapeng Su,Valentin Voillet,Lauren E Martin,Colton W Smith,Yuta Asano,Menna Hailemariam,Jakob Bakhtiari,Bo Lee,Cecilia Yeung,Hung Chen,Alessandro M Rizzi,Daniel G Chen,Kelsey Furiya,Nick Horst,Tianzi Zhang,Phung Le,Kelly McKenna,Shannon K Oda,Anthony Rongvaux,Phillip D Greenberg,Thomas M Schmitt,Aude G Chapuis

The FGFR1 N546K mutation confers resistance to pemigatinib in MLN-ZMYM2::FGFR1

FGFR1 N546K 突变赋予 MLN-ZMYM2::FGFR1 对 pemigatinib 的耐药性

Shoumariyeh, Khalid; Haug, Stefan; Schwaab, Juliana; Pfeil, Julie K; Stappenbeck, Jannis; Schmitt-Graeff, Annette; Naumann, Nicole; Waltemode, Greta; Zeiser, Robert; Miething, Cornelius; Hofmann, Wolf-Karsten; Meggendorfer, Manja; Diederichs, Sven; Duyster, Justus; Reiter, Andreas

A translational colorectal cancer organoid biobank mirrors patients' tumor histology, molecular profiles, and treatment responses

转化型结直肠癌类器官生物样本库能够反映患者的肿瘤组织学、分子特征和治疗反应。

Jesinghaus, Moritz; Silva, Miguel Gomes; Zaurito, Antonio Enrico; Brunner, Valentina; Saab, Frederic; Rajamani, Anantharamanan; de Andrade Krätzig, Niklas; Bodenstein, Nicholas; Guillemant, Rémi; Pohl, Junika; Schmitt, Maxime; Öllinger, Rupert; Fusco, Federico; Shakhtour, Julius; Klare, Peter; Janssen, Klaus-Peter; Foersch, Sebastian; Steiger, Katja; Rad, Roland; Pfarr, Nicole; Saur, Dieter; Tschurtschenthaler, Markus

Structure, mechanism and clinical relevance of NRG1 fusions in cancer

NRG1融合的结构、机制及其在癌症中的临床意义

Thiollier-Schmitt, Clarisse; Barre, Manon; Issenmann, Marie; Cros-Perrial, Emeline; Duruisseaux, Michaël; Jordheim, Lars Petter

The association between APOE 𝜀4 carrierships and the detection of amyloid positivity using an Alzheimer's disease proteomic blood test in asymptomatic Down syndrome

APOE ε4 携带者与无症状唐氏综合征患者使用阿尔茨海默病蛋白质组学血液检测发现淀粉样蛋白阳性之间的关联

Abdullah, Lubnaa Badriyyah; Zhang, Fan; Petersen, Melissa; Hall, James; Handen, Benjamin L; Mapstone, Mark; Christian, Brad; Head, Elizabeth; Harley, Sigan; Andrews, Howard; Lee, Joseph H; Tudorascu, Dana; Hom, Christy; Zaman, Shahid; Brickman, Adam M; Rosas, Diana; Cohen, Annie; Harp, Jordan P; Schmitt, Frederick; Ptomey, Lauren; Burns, Jeffrey M; Lott, Ira T; Lai, Florence; Laymon, Charles; Cruchaga, Carlos; O'Bryant, Sid; Ances, Beau M

Dysregulated expression of the tumor suppressor p14ARF in cancer provides an effective target for TCR-T cell therapeutics.

肿瘤抑制因子 p14ARF 在癌症中的表达失调为 TCR-T 细胞疗法提供了一个有效的靶点。

Schmitt Thomas M, Furiya Kelsey, Black Cheryl, Vazquez Angie, Sharma Jaishree, Hailemariam Menna, Paushter Daniel H, Trieu Lam, Lam Jennifer, Lee Bo, Rakhra Kavya, Whalen Kerry A, Mehta Naveen K, Sauer Karsten, Baeuerle Patrick A, Michaelson Jennifer S, Greenberg Philip D, Chapuis Aude G