日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Phase II Study to Assess the Safety and Efficacy of the Dual mTORC1/2 and PI3K Inhibitor Bimiralisib (PQR309) in Relapsed, Refractory Lymphoma

一项评估双重 mTORC1/2 和 PI3K 抑制剂 Bimiralisib (PQR309) 在复发难治性淋巴瘤中安全性和有效性的 II 期研究

Collins, Graham P; Eyre, Toby A; Schmitz-Rohmer, Debora; Townsend, William; Popat, Rakesh; Giulino-Roth, Lisa; Fields, Paul A; Krasniqi, Fatime; Soussain, Carole; Stathis, Anastasios; Andjelkovic, Nebojsa; Cunningham, David; Mandic, Danijela; Radulovic, Sinisa; Tijanic, Ivan; Horowitz, Netanel A; Kurtovic, Sabira; Schorb, Elisabeth; Schmidt, Christian; Dimitrijević, Saša; Dreyling, Martin

NDR functions as a physiological YAP1 kinase in the intestinal epithelium

NDR在肠上皮细胞中发挥生理性YAP1激酶的作用。

Zhang, Lei; Tang, Fengyuan; Terracciano, Luigi; Hynx, Debby; Kohler, Reto; Bichet, Sandrine; Hess, Daniel; Cron, Peter; Hemmings, Brian A; Hergovich, Alexander; Schmitz-Rohmer, Debora

NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development

NDR激酶在小鼠胚胎发育过程中对体节形成和心脏环化至关重要

Schmitz-Rohmer, Debora; Probst, Simone; Yang, Zhong-Zhou; Laurent, Frédéric; Stadler, Michael B; Zuniga, Aimée; Zeller, Rolf; Hynx, Debby; Hemmings, Brian A; Hergovich, Alexander

The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility

激酶 NDR1/2 作用于 Hippo 同源物 MST1 的下游,介导胸腺细胞从胸腺中流出以及淋巴细胞运动

Fengyuan Tang, Jason Gill, Xenia Ficht, Thomas Barthlott, Hauke Cornils, Debora Schmitz-Rohmer, Debby Hynx, Dawang Zhou, Lei Zhang, Gongda Xue, Michal Grzmil, Zhongzhou Yang, Alexander Hergovich, Georg A Hollaender, Jens V Stein, Brian A Hemmings, Patrick Matthias

hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme

hMOB3 调节 MST1 凋亡信号并支持多形性胶质母细胞瘤中的肿瘤生长

Fengyuan Tang, Lei Zhang, Gongda Xue, Debby Hynx, Yuhua Wang, Peter D Cron, Christian Hundsrucker, Alexander Hergovich, Stephan Frank, Brian A Hemmings, Debora Schmitz-Rohmer