日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Allosteric inhibition of JAK2 with lysine-reactive compounds that bind the pseudokinase domain

利用与假激酶结构域结合的赖氨酸反应性化合物对JAK2进行变构抑制

Primi, Marina C; Tavares, Maurício T; Hatcher, John M; Kang, Hyelim; Kresina, Tomás A C; Chakraborty, Sayan; Leroy, Emilie; Schmoker, Anna M; Jeon, Hyesung; Weisberg, Ellen L; Akatsu, Taisei; Griffin, James D; Scott, David A; Eck, Michael J

Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity.

分子伴侣介导的线粒体导入受体 TOM70 的插入可防止饮食引起的肥胖

Latorre-Muro Pedro, Vitale Tevis, Ravichandran Matthew, Zhang Katherine, Palozzi Jonathan M, Bennett Christopher F, Lamas-Paz Arantza, Sohn Jee Hyung, Jackson Thomas D, Jedrychowski Mark, Gygi Steven P, Kajimura Shingo, Schmoker Anna, Jeon Hyesung, Eck Michael J, Puigserver Pere

Cryo-EM structures of CRAF/MEK1/14-3-3 complexes in autoinhibited and open-monomer states reveal features of RAF regulation.

CRAF/MEK1/14-3-3 复合物在自身抑制和开放单体状态下的冷冻电镜结构揭示了 RAF 调控的特征

Jang Dong Man, Boxer Kayla, Ha Byung Hak, Tkacik Emre, Levitz Talya, Rawson Shaun, Metivier Rebecca J, Schmoker Anna, Jeon Hyesung, Eck Michael J

Unveiling the hidden interactome of CRBN molecular glues.

揭示 CRBN 分子胶的隐藏相互作用组

Baek Kheewoong, Metivier Rebecca J, Roy Burman Shourya S, Bushman Jonathan W, Yoon Hojong, Lumpkin Ryan J, Ryan Julia K, Abeja Dinah M, Lakshminarayan Megha, Yue Hong, Ojeda Samuel, Xiong Yuan, Che Jianwei, Verano Alyssa L, Schmoker Anna M, Gray Nathanael S, Donovan Katherine A, Fischer Eric S

Activation of the ciliary kinase CDKL5 is mediated by the cyclin-dependent kinase CDK20/LF2 to control flagellar length.

纤毛激酶 CDKL5 的激活是由细胞周期蛋白依赖性激酶 CDK20/LF2 介导的,从而控制鞭毛长度。

Hou Yuqing, Omi Oranti Ahmed, Stuck Michael W, Cheng Xi, Walker Bethany, Lam Ying-Wai, Schmoker Anna M, Nguyen Son N, Gonzalez-Perez Maria Paz, Ballif Bryan A, Lechtreck Karl F, Witman George B, Pazour Gregory J

The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A.

KRAS剪接变体的差异相互作用组鉴定出BIRC6是KRAS4A的泛素连接酶

Kochen Rossi Juan, Nuevo-Tapioles Cristina, O'Keefe Rachel A, Hunkeler Moritz, Schmoker Anna M, Fissore-O'Leary Mercedes, Su Wenjuan, Ahearn Ian M, Branco Cristina, Cheong Hakyung, Esposito Dominic, Clotea Ioana, Ueberheide Beatrix, Fischer Eric S, Philips Mark R

RAF isoform selectivity of MEK inhibitors and rational design of a covalent ARAF-MEK inhibitor

MEK抑制剂的RAF亚型选择性及共价ARAF-MEK抑制剂的合理设计

Chakraborty, Sayan; Jiang, Jie; Camallonga, Javier Vinals; Gazgalis, Dimitris; Gero, Thomas W; Tavares, Maurício T; Dittemore, Georgia; Tkacik, Emre; Jang, Dong Man; Ha, Byung Hak; Gottlieb, Felix H; Levitz, Talya; Metivier, Rebecca J; Schmoker, Anna M; Scott, David A; Jeon, Hyesung; Jänne, Pasi A; Eck, Michael J

Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues

利用DCAF16反式标记共价胶探索BRD4降解的可调控性

Hassan, Muhammad Murtaza; Li, Yen-Der; Ma, Michelle W; Teng, Mingxing; Byun, Woong Sub; Puvar, Kedar; Lumpkin, Ryan; Sandoval, Brittany; Rutter, Justine C; Jin, Cyrus Y; Wang, Michelle Y; Xu, Shawn; Schmoker, Anna M; Cheong, Hakyung; Groendyke, Brian J; Qi, Jun; Fischer, Eric S; Ebert, Benjamin L; Gray, Nathanael S

Bioorthogonally activated reactive species for target identification

用于靶标识别的生物正交活化活性物质

Siriwongsup, Surached; Schmoker, Anna M; Ficarro, Scott B; Marto, Jarrod A; Kim, Justin

Publisher Correction: Cryo-EM structure of a RAS/RAF recruitment complex

出版商更正:RAS/RAF募集复合物的冷冻电镜结构

Park, Eunyoung; Rawson, Shaun; Schmoker, Anna; Kim, Byeong-Won; Oh, Sehee; Song, Kangkang; Jeon, Hyesung; Eck, Michael J