日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Controlled human infection with Mycobacterium tuberculosis: practical considerations for clinical trials

控制性人体结核分枝杆菌感染:临床试验的实用性考量

Seshadri, Chetan; Flynn, JoAnne L; Maiello, Pauline; Schnappinger, Dirk; Wilkinson, Robert J; Gordon, Stephen B; Mwandumba, Henry C; Jambo, Kondwani C; Hoft, Daniel F; Rubin, Eric J; Jamrozik, Euzebiusz; Fortune, Sarah M; Kublin, James G

Activation of L-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis

激活L-组氨酸生物合成作为对抗结核分枝杆菌的新型抗生素策略

Hunt, Debbie M; Pisco, João Pedro; Rodgers, Angela; de Chiara, Cesira; Zaveri, Anisha; Pacholarz, Kamila L; Evangelopoulos, Dimitrios; Garza-Garcia, Acely; Ehrt, Sabine; Schnappinger, Dirk; Barran, Perdita E; Gutierrez, Maximiliano G; de Carvalho, Luiz Pedro S

A periplasmic protein complex mediates arabinofuranosyltransferase activity and intrinsic drug resistance in Mycobacterium tuberculosis

周质蛋白复合物介导结核分枝杆菌的阿拉伯呋喃糖基转移酶活性和内在耐药性

Klevorn, Thaís; Brown, Christopher; Hardy, Christine D; Cuthbert, Bonnie J; Spencer, Amanda; Jinich, Adrián; Chan, Luming; Angala, Shiva K; Manzer, Jordan; Mendoza, Jessica; de Miranda, Rodger; Kim, Heather; Schnappinger, Dirk; Jackson, Mary; Rhee, Kyu; Goulding, Celia W; Ehrt, Sabine

Identification and Evaluation of dibasic piperidines as novel cell wall inhibitors against Mycobacterium tuberculosis

鉴定和评价二元哌啶类化合物作为新型抗结核分枝杆菌细胞壁抑制剂

Naylor, Claire; Prosser, Gareth A; Bayliss, Tracy; Berle, Lila; Wallach, Joshua B; Kim, Heather; Olvera, Rodrigo Aguilera; Thompson, Stephen; Ioerger, Thomas R; Simpson, Laura; Casanueva, Ruth; Guijarro-Lopez, Laura; Read, Kevin D; Wyatt, Paul G; Schnappinger, Dirk; Barry, Clifton E; Green, Simon R; Boshoff, Helena I; Cleghorn, Laura A T

SuFEx-based antitubercular compound irreversibly inhibits Pks13

基于 SuFEx 的抗结核化合物不可逆地抑制 Pks13

Krieger, Inna V; Sukheja, Paridhi; Yang, Baiyuan; Tang, Su; Selle, Daniel; Woods, Ashley; Engelhart, Curtis; Kumar, Pradeep; Harbut, Michael B; Liu, Dongdong; Tsuda, Brendan; Qin, Bo; Bare, Grant A L; Li, Gencheng; Chi, Victor; Gambacurta, Julian; Hvizdos, Janine; Reagan, Matthew; Jones, Isabelle L; Massoudi, Lisa M; Woolhiser, Lisa K; Cascioferro, Alessandro; Kundrick, Erica; Singh, Parul; Reiley, William; Ioerger, Thomas R; Kandula, Dilipkumar Reddy; McCabe, Jacob W; Guo, Taijie; Alland, David; Boshoff, Helena I; Schnappinger, Dirk; Robertson, Gregory T; Mdluli, Khisi; Lee, Kyoung-Jin; Dong, Jiajia; Li, Shuangwei; Schultz, Peter G; Joseph, Sean B; Love, Melissa S; Sharpless, K Barry; Petrassi, H Michael; Chatterjee, Arnab K; Sacchettini, James C; McNamara, Case W

Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models

经基因工程改造的结核分枝杆菌三重杀菌开关菌株可在动物模型中实现可控的结核病感染

Xin Wang # ,Hongwei Su # ,Joshua B Wallach # ,Jeffrey C Wagner # ,Benjamin J Braunecker ,Michelle Gardner ,Kristine M Guinn ,Nicole C Howard ,Thais Klevorn ,Kan Lin ,Yue J Liu ,Yao Liu ,Douaa Mugahid ,Mark Rodgers ,Jaimie Sixsmith ,Shoko Wakabayashi ,Junhao Zhu ,Matthew Zimmerman ,Véronique Dartois ,JoAnne L Flynn ,Philana Ling Lin ,Sabine Ehrt ,Sarah M Fortune ,Eric J Rubin ,Dirk Schnappinger

A BCG kill switch strain protects against Mycobacterium tuberculosis in mice and non-human primates with improved safety and immunogenicity.

卡介苗杀灭开关菌株能够提高小鼠和非人灵长类动物对结核分枝杆菌的安全性和免疫原性。

Smith Alexander A, Su Hongwei, Wallach Joshua, Liu Yao, Maiello Pauline, Borish H Jacob, Winchell Caylin, Simonson Andrew W, Lin Philana Ling, Rodgers Mark, Fillmore Daniel, Sakal Jennifer, Lin Kan, Vinette Valerie, Schnappinger Dirk, Ehrt Sabine, Flynn JoAnne L

Attosecond spectroscopy of molecular charge transfer uncovers a 1.5-fs delay in population transfer

阿秒光谱学揭示了分子电荷转移过程中1.5飞秒的粒子数转移延迟。

Matselyukh, Danylo T; Rott, Florian; Schnappinger, Thomas; Zhang, Pengju; Li, Zheng; Richardson, Jeremy O; de Vivie-Riedle, Regina; Wörner, Hans Jakob

Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis

基于参考序列的化学-遗传相互作用分析阐明结核分枝杆菌中小分子的作用机制

Bond, Austin N; Orzechowski, Marek; Zhang, Shuting; Ben-Zion, Ishay; Lemmer, Allison; Garry, Nathaniel; Lee, Katie; Chen, Michael; Delano, Kayla; Gath, Emily; Golas, A Lorelei; Nietupski, Raymond; Fitzgerald, Michael; Ehrt, Sabine; Rubin, Eric J; Sassetti, Christopher M; Schnappinger, Dirk; Shoresh, Noam; Hunt, Diana K; Gomez, James E; Hung, Deborah T

Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action

多模态测量的整合揭示了结核病药物作用的关键机制

William C Johnson ,Ares Alivisatos ,Trever C Smith 2nd ,Nhi Van ,Vijay Soni ,Joshua B Wallach ,Nicholas A Clark ,Timothy A Fitzgerald ,Joshua J Whiteley ,Shumin Tan ,Artem Sokolov ,D Michael Ando ,Dirk Schnappinger ,Kyu Y Rhee ,Bree B Aldridge