日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca(2+) dependent allosteric binding site.

通过靶向 Ca(2+) 依赖性变构结合位点来抑制肽基精氨酸脱亚胺酶 (PAD1-4)

Dakin Leslie A, Xing Li, Hall Justin, Ding Weidong, Vajdos Felix F, Pelker Jeffrey W, Ramsey Simeon, Balbo Paul, Sahasrabudhe Parag V, Banker Mary Ellen, Choi Won Young, Wright Stephen W, Chang Jeanne S, Curto John M, Davoren Jennifer E, Drozda Susan E, Fennell Kimberly F, Futatsugi Kentaro, Kortum Steve, Lee Katherine L, Liu Shenping, Lovering Frank, Nicki Jennifer A, Trujillo John I, Vincent Fabien, Schnute Mark E

Peptidylarginine Deiminase (PAD) Inhibitor Optimization through Displacement of a Trapped Water Molecule

通过置换被捕获的水分子来优化肽基精氨酸脱亚胺酶(PAD)抑制剂

Schnute, Mark E; Chinigo, Gary M; Futatsugi, Kentaro; Yamaguchi, Masaya; Bagley, Scott W; Banker, Mary Ellen; Chang, Jeanne S; Chen, Ming Z; Choi, Won Young; Corbett, Matthew S; Drozda, Susan E; Ebner, David C; Garcia-Irizarry, Carmen; Hicklin, Robert; Hoy, Susan; Jiao, Wenhua; Kortum, Steven; Lee, Katherine L; Limburg, David C; Lovering, Frank; Moreno, Antonio; Mousseau, James J; Pan, Senliang; Parikh, Mihir D; Pelker, Jeffrey W; Ramsey, Simeon; Reilly, Usa; Rescourio, Gwenaella; Schmitt, Daniel C; Simpson, Brittany; Skrzypek, Grzegorz J; Smaltz, Daniel J; Taylor, Alexandria P; Torella, Rubben; Trujillo, John I; Vajdos, Felix F; Wepy, James A; Wright, Stephen W; Blakemore, David C; Vincent, Fabien; Clerin, Valerie M

Structural basis for CCR6 modulation by allosteric antagonists

变构拮抗剂调节 CCR6 的结构基础

David Jonathan Wasilko, Brian S Gerstenberger, Kathleen A Farley, Wei Li, Jennifer Alley, Mark E Schnute, Ray J Unwalla, Jorge Victorino, Kimberly K Crouse, Ru Ding, Parag V Sahasrabudhe, Fabien Vincent, Richard K Frisbie, Alpay Dermenci, Andrew Flick, Chulho Choi, Gary Chinigo, James J Mousseau, Jo

Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists

大环维甲酸受体相关孤儿受体C2反向激动剂

Schnute, Mark E; Trujillo, John I; Lee, Katherine L; Unwalla, Ray; Vajdos, Felix F; Kauppi, Björn; Nuhant, Philippe; Flick, Andrew C; Crouse, Kimberly K; Zhao, Yajuan; Samuel, Amanda; Lombardo, Vincent; Taylor, Alexandria P; Brault, Amy L; Knafels, John D; Vazquez, Michael L; Berstein, Gabriel

Ubiquitylation is required for the incorporation of the Notch receptor into intraluminal vesicles to prevent prolonged and ligand-independent activation of the pathway

泛素化是 Notch 受体整合到腔内囊泡中所必需的,以防止该通路的长期和非配体依赖性激活

Björn Schnute, Hideyuki Shimizu, Marvin Lyga, Martin Baron, Thomas Klein

A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases

两个位点的尾部:思维炸弹 E3 连接酶识别 Notch 配体的二分机制

Brian J McMillan, Björn Schnute, Nadja Ohlenhard, Brandon Zimmerman, Laura Miles, Natalia Beglova, Thomas Klein, Stephen C Blacklow

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

评估共价激酶抑制剂蛋白质组选择性的路线图

Bryan R Lanning #, Landon R Whitby #, Melissa M Dix, John Douhan, Adam M Gilbert, Erik C Hett, Theodore O Johnson, Chris Joslyn, John C Kath, Sherry Niessen, Lee R Roberts, Mark E Schnute, Chu Wang, Jonathan J Hulce, Baoxian Wei, Laurence O Whiteley, Matthew M Hayward, Benjamin F Cravatt

Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors

结构和抑制分析揭示了一系列聚集蛋白聚糖酶抑制剂的选择性机制

Micky D Tortorella, Alfredo G Tomasselli, Karl J Mathis, Mark E Schnute, Scott S Woodard, Grace Munie, Jennifer M Williams, Nicole Caspers, Arthur J Wittwer, Anne-Marie Malfait, Huey-Sheng Shieh