日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

In Vitro and In Vivo Evaluation of Nitroxoline as an Effective Antimicrobial Alternative to Poultry Production

体外和体内评价硝唑啉作为家禽生产中一种有效的抗菌替代品

Zhou, Yuqing; Trush, Maria M; Ibbotson, Lewis; Espina, Laura; Lankapalli, Aditya Kumar; Farley, Alistair J M; Song, Huangwei; Wu, Congming; Cao, Xingyuan; Xia, Xi; Gray-Hammerton, Charlotte J; Moorey, Alice; Delaitre, Amelie; Siegwart, George; Wang, Shaolin; Wang, Yang; Shen, Jianzhong; Schofield, Christopher J; Walsh, Timothy R

Structural and functional consequences of aspartate/asparagine-β-hydroxylase variants causing Traboulsi syndrome

导致特拉布尔西综合征的天冬氨酸/天冬酰胺-β-羟化酶变异体的结构和功能后果

Hou, Cynthia X; Brasnett, Amelia; Rabe, Patrick; Schofield, Christopher J; Brewitz, Lennart

Structure-guided optimisation of fenofibrate-derived oxidative phosphorylation inhibitors to modify tumour hypoxia

通过结构导向优化非诺贝特衍生的氧化磷酸化抑制剂以改善肿瘤乏氧

Holt-Martyn, James P; Machado, Nicole; Coates, James T T; Puliyadi, Rathi; Ashton, Thomas; Traynor, Elysia; Aslam, Samina; Wise, Thomas K; Rodriguez-Berriguete, Gonzalo; Schofield, Christopher J; Higgins, Geoff S

Structural and Functional Validation of Pseudomonas Savastanoi Ethylene Forming Enzymes Reveals Flexibility in 2-Oxoglutarate Binding Mode and Conformation

假单胞菌乙烯形成酶的结构和功能验证揭示了2-酮戊二酸结合模式和构象的灵活性

Sun, Yihong; Dhingra, Siddhant; Allen, Mark D; Cheng, Ethan S Z; Zhang, Zhihong; Schofield, Christopher J; Brewitz, Lennart

Building Localized NADP(H) Recycling Circuits to Advance Enzyme Cascadetronics

构建局部NADP(H)循环回路以推进酶级联电子学的发展

Herold, Ryan A; Schofield, Christopher J; Armstrong, Fraser A

Filamin C dimerisation is regulated by HSPB7.

丝状蛋白C二聚化受HSPB7调控

Wang Zihao, Cao Guodong, Collier Miranda P, Qiu Xingyu, Broadway-Stringer Sophie, Šaman Dominik, Ng Jediael Z Y, Sen Navoneel, Azad Amar J, Hooper Charlotte, Zimmermann Johannes, McDonough Michael A, Brem Jürgen, Rabe Patrick, Song Haigang, Alderson T Reid, Schofield Christopher J, Bolla Jani R, Djinovic-Carugo Kristina, Fürst Dieter O, Warscheid Bettina, Degiacomi Matteo T, Allison Timothy M, Hochberg Georg K A, Robinson Carol V, Gehmlich Katja, Benesch Justin L P

Light-Induced, Lysine-Targeting Irreversible Covalent Inhibition of the Human Oxygen Sensing Hydroxylase Factor Inhibiting HIF (FIH)

光诱导的赖氨酸靶向不可逆共价抑制人氧感应羟化酶因子HIF(FIH)

Wu, Yue; Li, Zhihong; Kaur, Samanpreet; Zhang, Zewei; Yue, Jie; Tumber, Anthony; Zhang, Haoshu; Song, Zhe; Yang, Peiyao; Dong, Ying; Yang, Fulai; Li, Xiang; Schofield, Christopher J; Zhang, Xiaojin

Evidence human FTO catalyses hydroxylation of N6-methyladenosine without direct formation of a demethylated product contrasting with ALKBH5/2/3 and bacterial AlkB

证据表明,人类FTO催化N6-甲基腺苷的羟基化,而不会直接生成去甲基化产物,这与ALKBH5/2/3和细菌AlkB形成对比。

Kaur, Simranjeet; Maheswaran, Pratheesh; Kaur, Samanpreet; Lai, Yingqi; Salah, Eidarus; Zhang, Dong; Shishodia, Shifali; Schofield, Christopher J; Aik, Wei Shen

Binding assays enable discovery of Tet(X) inhibitors that combat tetracycline destructase resistance

结合试验能够发现可对抗四环素破坏酶耐药性的Tet(X)抑制剂。

Beech, Matthew J; Toma, Edmond C; Smith, Helen G; Trush, Maria M; Ang, Jit H J; Wong, Mei Y; Wong, Chung H J; Ali, Hafiz S; Butt, Zakia; Goel, Viha; Duarte, Fernanda; Farley, Alistair J M; Walsh, Timothy R; Schofield, Christopher J

Revealing the catalytic mechanism of the Fe(II)/2-oxoglutarate-dependent human epigenetic modifying enzyme ALKBH5

揭示Fe(II)/2-氧戊二酸依赖性人类表观遗传修饰酶ALKBH5的催化机制

Cherilakkudy, Fathima Hameed; Thomas, Midhun George; Varghese, Ann; Waheed, Sodiq O; Krishnan, Anandhu; Venditti, Vincenzo; Schofield, Christopher J; Li, Deyu; Christov, Christo Z; Karabencheva-Christova, Tatyana G