日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Correlative Biomarker Analysis of PSMA Expression on CTCs and PSMA Imaging in a Phase I Study of PSMA Targeted Tubulysin Conjugate EC1169

在PSMA靶向Tubulysin缀合物EC1169的I期研究中,对CTC上PSMA表达进行相关性生物标志物分析和PSMA成像

Zaidi, Samir; Kuo, Phillip H; Paiva Prudente, Tiago; Lacuna, Kristine P; Babiker, Hani M; Aparicio, Renan; Schonhoft, Joseph D; Fernandez, Luisa; Messmann, Richard; Groaning, Michael; Tolcher, Anthony W; Gordon, Michael S; Yoo, Don C; Vaishampayan, Ulka; Picus, Joel; Petrylak, Daniel P; Sartor, Oliver; Morris, Michael J

Camonsertib, an ATRi, in Combination with Low-Dose Gemcitabine in Solid Tumors with DNA Damage Response Aberrations: Preclinical and Phase Ib Results

Camonsertib(一种ATRi)联合低剂量吉西他滨治疗伴有DNA损伤反应异常的实体瘤:临床前和Ib期研究结果

Rosen, Ezra Y; Yap, Timothy A; Fontana, Elisa; Lee, Elizabeth K; Mahalingam, Devalingam; Højgaard, Martin; Mettu, Niharika B; Cote, Gregory M; Plummer, Ruth; Koehler, Maria; Ulanet, Danielle; Fei, Kezhen; Silverman, Ian M; Schonhoft, Joseph D; Rimkunas, Victoria; Bacque, Emeline S; Gomez, Gabriela; Fretland, Adrian J; Roulston, Anne; Li, Li; Baruah, Prasamit; Zimmermann, Michal; Yang, Julia; Carneiro, Benedito A; Lheureux, Stephanie

Genomic and Epigenomic ctDNA Profiling in Liquid Biopsies from Heavily Pretreated Patients with DNA Damage Response-Deficient Tumors

对接受过大量预处理的DNA损伤反应缺陷型肿瘤患者的液体活检样本进行基因组和表观基因组ctDNA分析

Silverman, Ian M; Schonhoft, Joseph D; Herzberg, Benjamin; Yablonovitch, Arielle; Lagow, Errin; Fiaux, Patrick C; Safabakhsh, Pegah; Sethuraman, Sunantha; Ulanet, Danielle; Yang, Julia; Kim, Insil; Basciano, Paul; Cecchini, Michael; Lee, Elizabeth; Lheureux, Stephanie; Fontana, Elisa; Carneiro, Benedito A; Reis-Filho, Jorge S; Yap, Timothy A; Zinda, Michael; Rosen, Ezra Y; Rimkunas, Victoria

Exceptional response to the ATR inhibitor, camonsertib, in a patient with ALT+ metastatic melanoma

ATR抑制剂camonsertib在一名ALT+转移性黑色素瘤患者中表现出卓越的疗效

Ngoi, Natalie Y L; Silverman, Ian M; Johnson, Adrienne; Meng, Chenfeng; Schonhoft, Joseph D; Zimmermann, Michal; Ulanet, Danielle; Kim, Hyeyeon; Torrado, Carlos; Salguero, Carolina; Brown, Christian Valladolid; Rodon, Jordi; Rimkunas, Victoria; Koehler, Maria; Yap, Timothy A

The PLK4 inhibitor RP-1664 demonstrates potent single-agent efficacy in neuroblastoma models through a dual mechanism of sensitivity.

PLK4 抑制剂 RP-1664 通过双重敏感性机制在神经母细胞瘤模型中表现出强大的单药疗效

Maris John, Soria-Bretones Isabel, Casás-Selves Matias, Samanta Minu, Groff David, Murray Jayne, Fletcher Jamie, Farrel Alvin, Pastor Steven, Patel Khushbu, Goodfellow Elliot Goodfellow, Li Li, Caron Cathy, Shiwram Ariya, Kim Hyeyeon, Henry Danielle, Laterreur Nancy, Bowlan Julian, Krytska Kateryna, Neuhauser Steven, Stearns Timothy, Schubert Jeffrey, Wu Jinhua, Surrey Lea, Álvarez-Quilón Alejandro, Vallée Frédéric, Nejad Parham, Schonhoft Joseph, Li Joanna, Veloso Artur, Young Jordan, Hyer Marc, Morris Stephen, Mossé Yael P, Marshall Gary, Haber Michelle, Zimmermann Michal

Ataxia telangiectasia and Rad3-related (ATR) inhibitor camonsertib dose optimization in patients with biomarker-selected advanced solid tumors (TRESR study)

共济失调毛细血管扩张症和 Rad3 相关 (ATR) 抑制剂 camonsertib 在生物标志物选择的晚期实体瘤患者中的剂量优化 (TRESR 研究)

Fontana, Elisa; Rosen, Ezra; Lee, Elizabeth K; Højgaard, Martin; Mettu, Niharika B; Lheureux, Stephanie; Carneiro, Benedito A; Cote, Gregory M; Carter, Louise; Plummer, Ruth; Mahalingam, Devalingam; Fretland, Adrian J; Schonhoft, Joseph D; Silverman, Ian M; Wainszelbaum, Marisa; Xu, Yi; Ulanet, Danielle; Koehler, Maria; Yap, Timothy A

Phase 1b study of enzalutamide plus CC-115, a dual mTORC1/2 and DNA-PK inhibitor, in men with metastatic castration-resistant prostate cancer (mCRPC)

恩扎卢胺联合 CC-115(一种双重 mTORC1/2 和 DNA-PK 抑制剂)治疗转移性去势抵抗性前列腺癌 (mCRPC) 男性患者的 1b 期研究

Zhao, Jimmy L; Antonarakis, Emmanuel S; Cheng, Heather H; George, Daniel J; Aggarwal, Rahul; Riedel, Elyn; Sumiyoshi, Takayuki; Schonhoft, Joseph D; Anderson, Amanda; Mao, Ninghui; Haywood, Samuel; Decker, Brooke; Curley, Tracy; Abida, Wassim; Feng, Felix Y; Knudsen, Karen; Carver, Brett; Lacouture, Mario E; Wyatt, Alexander W; Rathkopf, Dana

Analysis of BRCA2 Copy Number Loss and Genomic Instability in Circulating Tumor Cells from Patients with Metastatic Castration-resistant Prostate Cancer

对转移性去势抵抗性前列腺癌患者循环肿瘤细胞中 BRCA2 拷贝数缺失和基因组不稳定性进行分析

Barnett, Ethan S; Schultz, Nikolaus; Stopsack, Konrad H; Lam, Ernest T; Arfe, Andrea; Lee, Jerry; Zhao, Jimmy L; Schonhoft, Joseph D; Carbone, Emily A; Keegan, Niamh M; Wibmer, Andreas; Wang, Yipeng; Solit, David B; Abida, Wassim; Wenstrup, Richard; Scher, Howard I

Circulating Tumor Cell Subtypes and T-cell Populations as Prognostic Biomarkers to Combination Immunotherapy in Patients with Metastatic Genitourinary Cancer

循环肿瘤细胞亚型和T细胞群作为转移性泌尿生殖系统癌症患者联合免疫治疗的预后生物标志物

Chalfin, Heather J; Pramparo, Tiziano; Mortazavi, Amir; Niglio, Scot A; Schonhoft, Joseph D; Jendrisak, Adam; Chu, Yen-Lin; Richardson, Robin; Krupa, Rachel; Anderson, Amanda K L; Wang, Yipeng; Dittamore, Ryan; Pal, Sumanta K; Lara, Primo N; Stein, Mark N; Quinn, David I; Steinberg, Seth M; Cordes, Lisa M; Ley, Lisa; Mallek, Marissa; Sierra Ortiz, Olena; Costello, Rene; Cadena, Jacqueline; Diaz, Carlos; Gulley, James L; Dahut, William L; Streicher, Howard; Wright, John J; Trepel, Jane B; Bottaro, Donald P; Apolo, Andrea B

Circulating Tumor Cell Chromosomal Instability and Neuroendocrine Phenotype by Immunomorphology and Poor Outcomes in Men with mCRPC Treated with Abiraterone or Enzalutamide

循环肿瘤细胞染色体不稳定性、免疫形态学神经内分泌表型与接受阿比特龙或恩扎卢胺治疗的转移性去势抵抗性前列腺癌(mCRPC)男性患者的不良预后相关

Brown, Landon C; Halabi, Susan; Schonhoft, Joseph D; Yang, Qian; Luo, Jun; Nanus, David M; Giannakakou, Paraskevi; Szmulewitz, Russell Z; Danila, Daniel C; Barnett, Ethan S; Carbone, Emily A; Zhao, Jimmy L; Healy, Patrick; Anand, Monika; Gill, Audrey; Jendrisak, Adam; Berry, William R; Gupta, Santosh; Gregory, Simon G; Wenstrup, Richard; Antonarakis, Emmanuel S; George, Daniel J; Scher, Howard I; Armstrong, Andrew J