日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Beamion PANTUMOR-1: rationale and design of a Phase II trial of zongertinib in HER2-overexpressed/amplified or HER2-mutant solid tumors

Beamion PANTUMOR-1:zongertinib治疗HER2过表达/扩增或HER2突变实体瘤的II期试验的理论依据和设计

Schram, Alison M; Park, John J; Italiano, Antoine; Kitano, Shigehisa; Guo, Ye; Li, Jin; Bedard, Philippe L; van Marcke, Cedric; Ko, Ryo; Lunger, Lukas; Klotz, Daniel M; Hussain, Jo; Maier, Daniela; Erzen, Damijan; Planchard, David; Prenen, Hans; Clay, Timothy D; Park, Joon O; Kim, Hyung-Don; Hernando-Calvo, Alberto; Maruki, Yuta; Ponz-Sarvise, Mariano; Dumbrava, Ecaterina

Coexistent PTEN and PIK3CA alterations hyperactivate mTORC1 signaling in endometrial cancers and cause their selective sensitivity to mTORC1 inhibition

PTEN 和 PIK3CA 的共存改变会过度激活子宫内膜癌中的 mTORC1 信号通路,并导致其对 mTORC1 抑制剂的选择性敏感性。

Solomon, Hilla; Mukherjee, Radha; Yang, Yu Chi; Meredith, Julia; Schram, Alison M; Yi, Sang Ah; Chen, Xiaoping; Tribuzio, Michael; Gundlapalli, Harika; Meyerowitz, Justin; de Stanchina, Elisa; Weigelt, Britta; An, Heeseon; Barry, Simon T; Smith, Jacqueline A M; Singh, Mallika; Rosen, Neal

Efficacy of Zenocutuzumab in NRG1 Fusion-Positive Cancer

Zenocutuzumab治疗NRG1融合阳性癌症的疗效

Schram, Alison M; Goto, Koichi; Kim, Dong-Wan; Macarulla, Teresa; Hollebecque, Antoine; O'Reilly, Eileen M; Ou, Sai-Hong Ignatius; Rodon, Jordi; Rha, Sun Young; Nishino, Kazumi; Duruisseaux, Michaël; Park, Joon Oh; Neuzillet, Cindy; Liu, Stephen V; Weinberg, Benjamin A; Cleary, James M; Calvo, Emiliano; Umemoto, Kumiko; Nagasaka, Misako; Springfeld, Christoph; Bekaii-Saab, Tanios; O'Kane, Grainne M; Opdam, Frans; Reiss, Kim A; Joe, Andrew K; Wasserman, Ernesto; Stalbovskaya, Viktoriya; Ford, Jim; Adeyemi, Shola; Jain, Lokesh; Jauhari, Shekeab; Drilon, Alexander

Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator.

Rezatapopt(一种小分子激活剂)可恢复 Y220C 突变 p53 的肿瘤抑制功能

Puzio-Kuter Anna M, Xu Lizhong, McBrayer Mary Kate, Dominique Romyr, Li Hongju H, Fahr Bruce J, Brown Alyssa M, Wiebesiek Amy E, Russo Brandon M, Mulligan Chris L, Yang Hong, Battaglia Josh, Robell Kimberly A, Thomas Dafydd H, Huang Kuo-Sen, Solovyov Alexander, Greenbaum Benjamin D, Oliner Jonathan D, Davis Thomas W, Dumble Melissa L, Johnson Melissa L, Xiong Shunbin, Yang Peirong, Lozano Guillermina, Fellous Marc M, Vu Binh T, Schram Alison M, Levine Arnold J, Poyurovsky Masha V

The Bi-steric, mTORC1-Selective Inhibitor, RMC-5552, in Advanced Solid Tumors: A Phase 1 Trial

双位阻 mTORC1 选择性抑制剂 RMC-5552 在晚期实体瘤中的应用:一项 1 期临床试验

Schram, Alison M; Naqash, Abdul Rafeh; Haura, Eric B; Riess, Jonathan W; Ulahannan, Susanna V; Ou, Sai-Hong I; Munster, Pamela N; Cheng, Michael L; Gustafson, W Clay; Bitman, Bojena; Friedman, Robert; Penn, Ruth; Kar, Sumit; Seshadri, Vidya; Wang, Zhican; Tao, Lin; Yang, Yu Chi; Singh, Mallika; Burris, Howard A; Meyerowitz, Justin G

CRESTONE: A Phase II Study of the Efficacy and Safety of the HER3 Monoclonal Antibody, Seribantumab, in Solid Tumors With Neuregulin-1 (NRG1) Fusions

CRESTONE:一项评估HER3单克隆抗体Seribantumab治疗伴有Neuregulin-1 (NRG1)融合的实体瘤的疗效和安全性的II期研究

Patil, Tejas; Lin, Jessica J; Cheema, Parneet K; Carrizosa, Daniel R; Burkard, Mark E; Elamin, Yasir Y; Desai, Jayesh; Patel, Jyoti D; Nagasaka, Misako; Reckamp, Karen L; Waqar, Saiama N; Bauman, Jessica R; Schram, Alison M; Gadgeel, Shirish M; Ma, Patrick C; Konduri, Kartik; Nguyen, Danny; Misleh, Jamal; Bleeker, Jonathan; Weiss, Matthias; Thavaneswaran, Subotheni; Haura, Eric B; Deegan, Maegan; Kaufman, Jonathan; Srivastava, Jaya; Jansen, Valerie M; Liu, Stephen V

Retrospective Analysis of BRCA-Altered Uterine Sarcoma Treated With Poly(ADP-ribose) Polymerase Inhibitors

回顾性分析采用聚(ADP-核糖)聚合酶抑制剂治疗的BRCA突变子宫肉瘤

Rao, Mara; Merrill, Madeline; Troxel, Megan; Chiang, Sarah; Momeni-Boroujeni, Amir; Hensley, Martee L; Schram, Alison M

PYNNACLE phase II clinical trial protocol: rezatapopt (PC14586) monotherapy in advanced or metastatic solid tumors with a TP53 Y220C mutation

PYNNACLE II期临床试验方案:rezatapopt (PC14586) 单药治疗携带 TP53 Y220C 突变的晚期或转移性实体瘤

Schram, Alison M; Fellous, Marc; LeDuke, Kim; Schmid, Anita; Dumbrava, Ecaterina E

Histology-Specific Clinical Trial of Lenvatinib and Pembrolizumab in Patients with Sarcoma

针对肉瘤患者的乐伐替尼和帕博利珠单抗组织学特异性临床试验

Movva, Sujana; Seier, Kenneth; Avutu, Viswatej; Banks, Lauren B; Chan, Jason; Chi, Ping; Dickson, Mark A; Gounder, Mrinal M; Kelly, Ciara M; Keohan, Mary L; Maki, Robert; Rosenbaum, Evan; Salcito, Tiffany; Rodriguez, Kaithleen; Dempsey, Rebecca; Meyers, Paul A; Cohen, Seth M; Hensley, Martee L; Konner, Jason A; Schram, Alison M; Lefkowitz, Robert A; Erinjeri, Joseph P; Qin, Li-Xuan; Tap, William D; D'Angelo, Sandra P

Convergent evolution of BRCA2 reversion mutations under therapeutic pressure by PARP inhibition and platinum chemotherapy

在PARP抑制剂和铂类化疗的治疗压力下,BRCA2回复突变趋同进化

Walmsley, Charlotte S; Jonsson, Philip; Cheng, Michael L; McBride, Sean; Kaeser, Christopher; Vargas, Herbert Alberto; Laudone, Vincent; Taylor, Barry S; Kappagantula, Rajya; Baez, Priscilla; Richards, Allison L; Noronha, Anne Marie; Perera, Dilmi; Berger, Michael; Solit, David B; Iacobuzio-Donahue, Christine A; Scher, Howard I; Donoghue, Mark T A; Abida, Wassim; Schram, Alison M