日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting of Epithelial Cell Adhesion Molecule-Expressing Malignant Tumors Using an Albumin-Binding Domain-Fused Designed Ankyrin Repeat Protein: Effect of the Molecular Architecture

利用白蛋白结合域融合设计的锚蛋白重复序列蛋白靶向表达上皮细胞黏附分子的恶性肿瘤:分子结构的影响

Tolmachev, Vladimir; Vorobyeva, Anzhelika; Rosly, Alia Hani Binti; Garousi, Javad; Liu, Yongsheng; Gräslund, Torbjörn; Papalanis, Eleftherios; Schulga, Alexey; Konovalova, Elena; Orlova, Anna; Deyev, Sergey M; Oroujeni, Maryam

Comparative Preclinical Evaluation of the Tumor-Targeting Properties of Radioiodine and Technetium-Labeled Designed Ankyrin Repeat Proteins for Imaging of Epidermal Growth Factor Receptor Expression in Malignant Tumors

放射性碘和锝标记的定制锚蛋白重复序列蛋白在恶性肿瘤表皮生长因子受体表达成像中的肿瘤靶向特性比较临床前评价

Larkina, Mariia; Yanovich, Gleb; Hasnowo, Lutfi Aditya; Varvashenya, Ruslan; Yuldasheva, Feruza; Tretyakova, Maria; Plotnikov, Evgenii; Zelchan, Roman; Schulga, Alexey; Konovalova, Elena; Ziganshin, Rustam; Belousov, Mikhail V; Tolmachev, Vladimir; Deyev, Sergey M

Fusion of SARS-CoV-2 neutralizing LCB1 peptide with Bacillus amyloliquefaciens RNase improves antiviral efficacy.

将 SARS-CoV-2 中和肽 LCB1 与枯草芽孢杆菌 RNase 融合可提高抗病毒功效

Kostin Nikita N, Bobik Tatyana V, Konovalova Elena V, Kocharovskaya Milita V, Simonova Maria A, Rushkevich Natalia Yu, Mokrushina Yuliana A, Skryabin George A, Kalinin Roman S, Kovalchuk Sergey I, Ziganshin Rustam H, Kaluzhskiy Leonid A, Gnedenko Oksana V, Yablokov Evgeniy O, Ivanov Alexis S, Chernov Aleksandr S, Kazakov Vitaly A, Khokhlova Oksana N, Murashev Arkady N, Hong Senlian, Shramova Elena I, Schulga Alexey A, Lyukmanova Ekaterina N, Kirpichnikov Mikhail P, Smirnov Ivan V, Belogurov Alexey A, Rubtsov Yuri P, Stepanov Alexey V, Zhang Hongkai, Gabibov Alexander G, Deyev Sergey M

Targeted Delivery of HSP70 to Tumor Cells via Supramolecular Complex Based on HER2-Specific DARPin9_29 and the Barnase:Barstar Pair

基于HER2特异性DARPin9_29和Barnase:Barstar对的超分子复合物,将HSP70靶向递送至肿瘤细胞。

Alekseeva, Ludmila G; Ovsyanikova, Olga V; Schulga, Alexey A; Grechikhina, Maria V; Shustova, Olga A; Kovalenko, Elena I; Svirshchevskaya, Elena V; Deyev, Sergey M; Sapozhnikov, Alexander M

Structural Basis of Activity of HER2-Targeting Construct Composed of DARPin G3 and Albumin-Binding Domains

由DARPin G3和白蛋白结合域组成的HER2靶向构建体的活性结构基础

Konshina, Anastasia G; Bocharov, Eduard V; Konovalova, Elena V; Schulga, Alexey A; Tolmachev, Vladimir; Deyev, Sergey M; Efremov, Roman G

Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [(99m)Tc]Tc(CO)(3)-(HE)(3)-Ec1 for Visualization of EpCAM-Expressing Lung Cancer

针对表达EpCAM的肺癌,对设计型锚蛋白重复序列蛋白[(99m)Tc]Tc(CO)3-(HE)3-Ec1进行I期临床评估

Zelchan, Roman; Chernov, Vladimir; Medvedeva, Anna; Rybina, Anastasia; Bragina, Olga; Mishina, Elizaveta; Larkina, Mariia; Varvashenya, Ruslan; Fominykh, Anastasia; Schulga, Alexey; Konovalova, Elena; Vorobyeva, Anzhelika; Orlova, Anna; Tashireva, Liubov; Deyev, Sergey M; Tolmachev, Vladimir

Direct Intra-Patient Comparison of Scaffold Protein-Based Tracers, [(99m)Tc]Tc-ADAPT6 and [(99m)Tc]Tc-(HE)(3)-G3, for Imaging of HER2-Positive Breast Cancer

支架蛋白示踪剂[(99m)Tc]Tc-ADAPT6和[(99m)Tc]Tc-(HE)3-G3在HER2阳性乳腺癌显像中的直接患者内比较

Bragina, Olga; Chernov, Vladimir; Schulga, Alexey; Konovalova, Elena; Hober, Sophia; Deyev, Sergey; Sörensen, Jens; Tolmachev, Vladimir

Visualization of epithelial cell adhesion molecule-expressing renal cell carcinoma xenografts using designed ankyrin repeat protein Ec1 labelled with (99m)Tc and (125)I

利用经设计的锚蛋白重复序列蛋白 Ec1 标记(99mTc 和 125I),对表达上皮细胞黏附分子的肾细胞癌异种移植瘤进行可视化。

Tolmachev, Vladimir; Bodenko, Vitalina; Orlova, Anna; Schulga, Alexey; Deyev, Sergey M; Vorobyeva, Anzhelika

Switchable targeting of solid tumors by BsCAR T cells.

BsCAR T 细胞对实体瘤的可切换靶向性

Stepanov Alexey V, Kalinin Roman S, Shipunova Victoria O, Zhang Ding, Xie Jia, Rubtsov Yuri P, Ukrainskaya Valeria M, Schulga Alexey, Konovalova Elena V, Volkov Dmitry V, Yaroshevich Igor A, Moysenovich Anastasiia M, Belogurov Alexey A Jr, Zhang Hongkai, Telegin Georgij B, Chernov Alexandr S, Maschan Mikhail A, Terekhov Stanislav S, Wu Peng, Deyev Sergey M, Lerner Richard A, Gabibov Alexander G, Altman Sidney

Direct In Vivo Comparison of (99m)Tc-Labeled Scaffold Proteins, DARPin G3 and ADAPT6, for Visualization of HER2 Expression and Monitoring of Early Response for Trastuzumab Therapy

直接体内比较 (99m)Tc 标记的支架蛋白 DARPin G3 和 ADAPT6,用于可视化 HER2 表达和监测曲妥珠单抗治疗的早期反应

Tolmachev, Vladimir; Bodenko, Vitalina; Oroujeni, Maryam; Deyev, Sergey; Konovalova, Elena; Schulga, Alexey; Lindbo, Sarah; Hober, Sophia; Bragina, Olga; Orlova, Anna; Vorobyeva, Anzhelika