日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Fragment-Based Inhibitors of SARS-CoV-2 PL(Pro)

SARS-CoV-2 PL(Pro)片段抑制剂的发现

Wei, Qiangqiang; Taylor, Ashley J; Barmade, Mahesh Angadrao; Teuscher, Kevin B; Chowdhury, Somanath; Apakama, Chideraa; Anderson-Daniels, Jordan; Yongqing, Zhu; Schultz, David C; Rietz, Tyson A; South, Taylor M; Crow, Mackenzie M; Zhao, Bin; Amporndanai, Kangsa; Sensintaffar, John L; Phan, Jason; Cherry, Sara; Denison, Mark; Lee, Taekyu; Fesik, Stephen W

Infection Of Rhesus Macaques With O'nyong-nyong Virus UVIR-O804 Recapitulates Key Aspects of Human Clinical Disease

恒河猴感染奥尼昂尼昂病毒UVIR-O804可重现人类临床疾病的关键特征

Jaeger, Hannah K; Denton, Michael; Andoh, Takeshi F; Kreklywich, Craig N; Gao, Lina; Pung, Lydia J; Streblow, Zachary J; McMonigal, Ann; Ray, Karina; Graves, Brayden; Streblow, Magdalene M; Barber-Axthelm, Aaron M; Zilverberg, Gavin; Terry, Margaret; Fei, Suzanne S; Hogan, Glenn; Schultz, David C; Cherry, Sara; Axthelm, Michael K; Labriola, Caralyn S; Heise, Mark; Streblow, Daniel N

Mechanism and spectrum of inhibition of viral polymerases by 2'-deoxy-2'-β-fluoro-4'-azidocytidine or azvudine.

2'-脱氧-2'-β-氟-4'-叠氮胞苷或阿兹夫定抑制病毒聚合酶的机制和范围

Lee Hery W, Tchesnokov Egor P, Stevens Laura J, Hughes Tia M, Diefenbacher Meghan V, Woolner Emma, Kocincova Dana, Schultz David C, Cherry Sara, Sheahan Timothy P, Denison Mark R, Götte Matthias

Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence.

组蛋白伴侣 HIRA、早幼粒细胞白血病蛋白和 p62/SQSTM1 协同调节细胞衰老过程中的炎症

Dasgupta Nirmalya, Lei Xue, Shi Christina Huan, Arnold Rouven, Teneche Marcos G, Miller Karl N, Rajesh Adarsh, Davis Andrew, Anschau Valesca, Campos Alexandre R, Gilson Rebecca, Havas Aaron, Yin Shanshan, Chua Zong Ming, Liu Tianhui, Proulx Jessica, Alcaraz Michael, Rather Mohammed Iqbal, Baeza Josue, Schultz David C, Yip Kevin Y, Berger Shelley L, Adams Peter D

An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo.

SARS-CoV-2 Mpro 的口服非共价非肽抑制剂可改善体内病毒复制和致病性

Zhou Nian E, Tang Su, Bian Xuelin, Parai Maloy K, Krieger Inna V, Flores Armando, Jaiswal Pradeep K, Bam Radha, Wood Jeremy L, Shi Zhe, Stevens Laura J, Scobey Trevor, Diefenbacher Meghan V, Moreira Fernando R, Baric Thomas J, Acharya Arjun, Shin Joonyoung, Rathi Manish M, Wolff Karen C, Riva Laura, Bakowski Malina A, McNamara Case W, Catanzaro Nicholas J, Graham Rachel L, Schultz David C, Cherry Sara, Kawaoka Yoshihiro, Halfmann Peter J, Baric Ralph S, Denison Mark R, Sheahan Timothy P, Sacchettini James C

HIRA complex deposition of histone H3.3 is driven by histone tetramerization and histone-DNA binding

HIRA复合物对组蛋白H3.3的沉积是由组蛋白四聚化和组蛋白-DNA结合驱动的。

Vogt, Austin; Szurgot, Mary; Gardner, Lauren; Schultz, David C; Marmorstein, Ronen

Trametinib Sensitivity is Defined by a Myeloid Differentiation Profile in Acute Myeloid Leukemia

急性髓系白血病中,曲美替尼敏感性由髓系分化谱决定。

Quesnel-Vallières, Mathieu; Schultz, David C; Orlenko, Alena; Lo, Yancy; Moore, Jason; Ritchie, Marylyn; Roth, David; Carroll, Martin; Barash, Yoseph; Lynch, Kristen W; Cherry, Sara

Immune history shapes human antibody responses to H5N1 influenza viruses

免疫史影响人类对H5N1流感病毒的抗体反应

Garretson, Tyler A; Liu, Jiaojiao; Li, Shuk Hang; Scher, Gabrielle; Santos, Jefferson J S; Hogan, Glenn; Vieira, Marcos Costa; Furey, Colleen; Atkinson, Reilly K; Ye, Naiqing; Ort, Jordan; Kim, Kangchon; Hernandez, Kevin A; Eilola, Theresa; Schultz, David C; Cherry, Sara; Cobey, Sarah; Hensley, Scott E

Pyrimidine biosynthesis inhibitors synergize with nucleoside analogs to block SARS-CoV-2 infection

嘧啶生物合成抑制剂与核苷类似物协同作用,可阻断SARS-CoV-2感染。

Schultz, David C; Johnson, Robert M; Ayyanathan, Kasirajan; Miller, Jesse; Whig, Kanupriya; Kamalia, Brinda; Dittmar, Mark; Weston, Stuart; Hammond, Holly L; Dillen, Carly; Castellana, Lauren; Lee, Jae Seung; Li, Minghua; Lee, Emily; Constant, Samuel; Ferrer, Marc; Thaiss, Christoph A; Frieman, Matthew B; Cherry, Sara

Adaptive mitochondrial reprogramming and resistance to PI3K therapy

线粒体适应性重编程和对PI3K疗法的耐药性

Ghosh, Jagadish C; Siegelin, Markus D; Vaira, Valentina; Faversani, Alice; Tavecchio, Michele; Chae, Young Chan; Lisanti, Sofia; Rampini, Paolo; Giroda, Massimo; Caino, M Cecilia; Seo, Jae Ho; Kossenkov, Andrew V; Michalek, Ryan D; Schultz, David C; Bosari, Silvano; Languino, Lucia R; Altieri, Dario C