日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Metformin induces ferroptosis associated with lipidomic remodeling in AML

二甲双胍诱导的铁死亡与急性髓系白血病中的脂质组重塑有关

Sternadt, Dominique; Pereira-Martins, Diego A; Chatzikyriakou, Prodromos; Albuquerque-Simões, Luise; Yang, Ming; Silveira, Douglas R A; Wierenga, Albertus T J; Weinhäuser, Isabel; Hogeling, Shanna M; Oudejans, Lieve L; Casares Alaez, Pilar; Sarry, Jean-Emmanuel; Frezza, Christian; Huls, Gerwin A; Quek, Lynn; Schuringa, Jan Jacob

Autophagy inhibition potentiates the antileukemic effect of FLT3 inhibitors and overcomes resistance in FLT3-ITD acute myeloid leukemia

自噬抑制可增强FLT3抑制剂的抗白血病作用,并克服FLT3-ITD急性髓系白血病的耐药性。

Albuquerque de Melo, Manuela; Santos de Macedo, Brunno Gilberto; Pereira-Martins, Diego A; Alves-Silva, Antônio Bruno; Fonseca, Natasha Peixoto; de Miranda, Livia Bassani Lins; Silva, Cleide Lucia Araújo; Scheucher, Priscila Santos; Schuringa, Jan Jacob; Machado-Neto, João Agostinho; Traina, Fabiola

Pharmacological boosting of azacitidine/venetoclax in acute myeloid leukemia

药物增强阿扎胞苷/维奈托克在急性髓系白血病中的疗效

Westra, Niels; Cerro, Elena Ropero; Schilder, Edwin; Lub-de Hooge, Marjolijn N; Touw, Daan J; Kosterink, Jos G W; Chitu, Dana A; Ammatuna, Emanuele; Klein, Saskia K; Westerweel, Peter E; Cuijpers, Marloes; Cruijsen, Marjan; Corsten, Maarten M F; Alhan, Canan; Tick, Lidwine; Schuringa, Jan Jacob; Huls, Gerwin; Woolthuis, Carolien M; Oude Munnink, Thijs H

High mtDNA content identifies oxidative phosphorylation-driven acute myeloid leukemias and represents a therapeutic vulnerability

高线粒体DNA含量是氧化磷酸化驱动型急性髓系白血病的特征性标志,也是治疗上的一个难点。

Pereira-Martins, Diego A; Weinhäuser, Isabel; Griessinger, Emmanuel; Coelho-Silva, Juan L; Silveira, Douglas R; Sternadt, Dominique; Erdem, Ayşegül; Duarte, Bruno Kosa L; Chatzikyriakou, Prodromos; Quek, Lynn; Alves-Silva, Antonio Bruno; Traina, Fabiola; Olalla Saad, Sara T; Hilberink, Jacobien R; Moreira-Aguiar, Amanda; Salustiano-Bandeira, Maria L; Lima, Marinus M; Franca-Neto, Pedro L; Bezerra, Marcos A; van der Meer, Nisha K; Ammatuna, Emanuele; Rego, Eduardo M; Huls, Gerwin; Schuringa, Jan Jacob; Lucena-Araujo, Antonio R

Lactate dehydrogenase A-coupled NAD(+) regeneration is critical for acute myeloid leukemia cell survival

乳酸脱氢酶A偶联的NAD(+)再生对急性髓系白血病细胞的存活至关重要。

Erdem, Ayşegül; Kaye, Séléna; Caligiore, Francesco; Johanns, Manuel; Leguay, Fleur; Schuringa, Jan Jacob; Ito, Keisuke; Bommer, Guido; van Gastel, Nick

K12-ligand-based CAR T cell therapy for CD7-positive T cell malignancies.

基于K12配体的CAR T细胞疗法治疗CD7阳性T细胞恶性肿瘤

Visser Nienke, González-Corrales Macarena, Álvarez-Freile Jimena, Pruis Maurien G, Rockstein Lena, Lourens Harm Jan, Schuringa Jan Jacob, van Meerten Tom, Huls Gerwin, Bremer Edwin

High expression of signal regulatory protein beta 2 marks a favourable prognostic AML subgroup and associates with increased sensitivity to phagocytosis

信号调节蛋白β2的高表达标志着预后良好的急性髓系白血病(AML)亚组,并与吞噬敏感性增加相关。

Visser, Nienke; van der Meer, Nisha K; He, Yuan; Huls, Gerwin; Schuringa, Jan Jacob; Bremer, Edwin

Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias

强效、选择性menin-KMT2A抑制剂JNJ-75276617(bleximenib)在KMT2A和NPM1改变的白血病中的临床前疗效

Kwon, Min Chul; Thuring, Jan Willem; Querolle, Olivier; Dai, Xuedong; Verhulst, Tinne; Pande, Vineet; Marien, Ann; Goffin, Dries; Wenge, Daniela V; Yue, Hong; Cutler, Jevon A; Jin, Cyrus; Perner, Florian; Hogeling, Shanna M; Shaffer, Paul L; Jacobs, Frank; Vinken, Petra; Cai, Wei; Keersmaekers, Vikki; Eyassu, Filmon; Bhogal, Balpreet; Verstraeten, Karin; El Ashkar, Sara; Perry, Jennifer A; Jayaguru, Prathiba; Barreyro, Laura; Kuchnio, Anna; Darville, Nicolas; Krosky, Daniel; Urbanietz, Gregor; Verbist, Bie; Edwards, James P; Cowley, Glenn S; Kirkpatrick, Robert; Steele, Ruth; Ferrante, Lucille; Guttke, Christina; Daskalakis, Nikki; Pietsch, E Christine; Wilson, David M; Attar, Ricardo; Elsayed, Yusri; Fischer, Eric S; Schuringa, Jan Jacob; Armstrong, Scott A; Packman, Kathryn; Philippar, Ulrike

Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation

硬脂酰辅酶A去饱和酶抑制剂对具有高水平从头脂肪酸生物合成和去饱和作用的急性髓系白血病具有毒性。

Dembitz, Vilma; Lawson, Hannah; Burt, Richard; Natani, Sirisha; Philippe, Céline; James, Sophie C; Atkinson, Samantha; Durko, Jozef; Wang, Lydia M; Campos, Joana; Magee, Aoife M S; Woodley, Keith; Austin, Michael J; Rio-Machin, Ana; Casado, Pedro; Bewicke-Copley, Findlay; Rodriguez Blanco, Giovanny; Pereira-Martins, Diego; Oudejans, Lieve; Boet, Emeline; von Kriegsheim, Alex; Schwaller, Juerg; Finch, Andrew J; Patel, Bela; Sarry, Jean-Emmanuel; Tamburini, Jerome; Schuringa, Jan Jacob; Hazlehurst, Lori; Copland Iii, John A; Yuneva, Mariia; Peck, Barrie; Cutillas, Pedro; Fitzgibbon, Jude; Rouault-Pierre, Kevin; Kranc, Kamil; Gallipoli, Paolo

Optimization of Cell Membrane Purification for the Preparation and Characterization of Cell Membrane Liposomes.

细胞膜纯化的优化及其在细胞膜脂质体制备和表征中的应用

de Weerd Sander, Ruiter Emma A, Calicchia Eleonora, Portale Giuseppe, Schuringa Jan Jacob, Roos Wouter H, Salvati Anna