日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Capsaicin-Inspired Hydroxamate Hybrids as Selective HDAC6 Inhibitors with Antiproliferative Activity in Hematological Malignancies

辣椒素衍生的羟肟酸酯杂合物作为选择性 HDAC6 抑制剂,在血液恶性肿瘤中具有抗增殖活性

Gimenez Borges, Lara; Alves, Thais Nascimento de Oliveira; Vassiliades, Sandra Valeria; Carlos, Jorge Antonio Elias Godoy; Waitman, Karoline de Barros; Hilscher, Sebastian; Schutkowski, Mike; Sippl, Wolfgang; Tavares, Maurício Temotheo; Toledo, Monica Franco Zannini Junqueira; Costa-Lotufo, Letícia Veras; Kronenberger, Thales; Machado-Neto, João Agostinho; Parise-Filho, Roberto

Total Synthesis and Structural Revision of Keenamide A

Keenamide A 的全合成及结构修正

Koch, Lukas; Wiedemann, Christoph; Parthier, Christoph; Seidel, Rüdiger W; Stubbs, Milton T; Schutkowski, Mike; Meleshin, Marat

From Pharmacophore to Warhead: NAD(+)-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors

从药效团到活性位点:靶向 NAD(+) 的三唑类化合物作为基于机制的 Sirtuin 抑制剂

Friedrich, Florian; Meleshin, Marat; Papenkordt, Niklas; Gaitzsch, Lena; Prucker, Isabel; Borso, Marco; Ruprecht, Jan; Vorreiter, Christopher; Rast, Sabrina; Zhang, Lin; Schiedel, Matthias; Sippl, Wolfgang; Imhof, Axel; Jessen, Henning J; Einsle, Oliver; Schutkowski, Mike; Jung, Manfred

The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells

蛋白质去乙酰化酶HDAC10控制恶性淋巴细胞中的DNA复制。

Mieland, Andreas O; Petrosino, Giuseppe; Dejung, Mario; Chen, Jia-Xuan; Fulzele, Amitkumar; Mahmoudi, Fereshteh; Tu, Jia-Wey; Mustafa, Al-Hassan M; Zeyn, Yanira; Hieber, Christoph; Bros, Matthias; Schnöder, Tina M; Heidel, Florian H; Najafi, Sara; Oehme, Ina; Hofmann, Ilse; Schutkowski, Mike; Hilscher, Sebastian; Kosan, Christian; Butter, Falk; Bhatia, Sanil; Sippl, Wolfgang; Krämer, Oliver H

Efficient Crystallization of Apo Sirt2 for Small-Molecule Soaking and Structural Analysis of Ligand Interactions.

高效结晶 Apo Sirt2 用于小分子浸泡和配体相互作用的结构分析

Friedrich Florian, Schiedel Matthias, Swyter Sören, Zhang Lin, Sippl Wolfgang, Schutkowski Mike, Einsle Oliver, Jung Manfred

Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment

唐娜·弗洛尔和她的两位丈夫:发现用于治疗髓系癌症的新型HDAC6/AKT2抑制剂

Waitman, Karoline B; Martin, Holli-Joi; Carlos, Jorge A E G; Braga, Rodolpho C; Souza, Vinícius A M; Melo-Filho, Cleber C; Hilscher, Sebastian; Toledo, Mônica F Z J; Tavares, Maurício T; Costa-Lotufo, Letícia V; Machado-Neto, João A; Schutkowski, Mike; Sippl, Wolfgang; Kronenberger, Thales; Alves, Vinicius M; Parise-Filho, Roberto; Muratov, Eugene N

Substrate-Guided Development of HDAC11-Selective Inhibitors Featuring α‑Amino Amide Zinc-Binding Groups

基于底物导向的HDAC11选择性抑制剂的开发,该抑制剂具有α-氨基酰胺锌结合基团

Hilscher, Sebastian; Meleshin, Marat; Baselious, Fady; Barinka, Cyril; Sippl, Wolfgang; Schutkowski, Mike; Schiene-Fischer, Cordelia

Novel selective indole based histone deacetylase 10 inhibitors as anticancer therapeutics

新型选择性吲哚类组蛋白去乙酰化酶10抑制剂作为抗癌疗法

Tarawneh, Amer H; Al-Trawneh, Salah A; Yesiloglu, Talha Z; Zessin, Matthes; Robaa, Dina; Barinka, Cyril; Schutkowski, Mike; Sippl, Wolfgang; Ross, Samir A

Development of potent and selective tetrahydro-β-carboline-based HDAC6 inhibitors with promising activity against triple-negative breast cancer.

开发高效且选择性的四氢-β-咔啉类HDAC6抑制剂,对三阴性乳腺癌具有良好的活性

Fathy Aya, Allam Amro, ElHady Ahmed K, El-Gamil Dalia S, Lin Kai-Chun, Chang Yen-Hua, Lee Yu-Hsuan, Hilscher Sebastian, Schutkowski Mike, Ibrahim Hany S, Chen Shun-Hua, Chen Chun-Hong, Abadi Ashraf H, Sippl Wolfgang, Chen Po-Jen, Cheng Yi-Sheng, Abdel-Halim Mohammad

Epigenetic-based differentiation therapy for Acute Myeloid Leukemia

基于表观遗传学的急性髓系白血病分化疗法

Edurne San José-Enériz # ,Naroa Gimenez-Camino # ,Obdulia Rabal ,Leire Garate ,Estibaliz Miranda ,Nahia Gómez-Echarte ,Fernando García ,Stella Charalampopoulou ,Elena Sáez ,Amaia Vilas-Zornoza ,Patxi San Martín-Uriz ,Luis V Valcárcel ,Naroa Barrena ,Diego Alignani ,Luis Esteban Tamariz-Amador ,Ana Pérez-Ruiz ,Sebastian Hilscher ,Mike Schutkowski ,Ana Alfonso-Pierola ,Nicolás Martinez-Calle ,María José Larrayoz ,Bruno Paiva ,María José Calasanz ,Javier Muñoz ,Marta Isasa ,José Ignacio Martin-Subero ,Antonio Pineda-Lucena ,Julen Oyarzabal ,Xabier Agirre ,Felipe Prósper