日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Addressing a Common Misconception of Simple Additive and Cumulative Drug Inhibition: Multiple Weak Inhibitors of Common Metabolic Pathway Do Not Pose a Strong Interaction Risk!

纠正关于简单叠加和累积药物抑制的常见误解:多种弱抑制剂共同作用于同一代谢途径并不构成强烈的相互作用风险!

Scotcher, Daniel; Ghosh, Avijit; Galetin, Aleksandra; Rostami-Hodjegan, Amin

5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer

5-甲基胞嘧啶和5-羟甲基胞嘧啶是结直肠癌早期检测的协同生物标志物。

Puddu, Fabio; Johansson, Annelie; Modat, Aurélie; Scotcher, Jamie; Sethi, Riccha; Yu, Shirong; Harding, Nick; Hill, Mark; Lleshi, Ermira; Lumby, Casper; Teyssandier, Jean; Wilson, Michael; Crawford, Robert; Charlesworth, Tom; Creed, Páidí; Balasubramanian, Shankar; Osborne, Robert J

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

OGT通过全基因组抑制TET活性,防止DNA去甲基化并抑制异染色质中转座元件的表达。

Hugo Sepulveda # ,Xiang Li # ,Leo J Arteaga-Vazquez ,Isaac F López-Moyado ,Melina Brunelli ,Lot Hernández-Espinosa ,Xiaojing Yue ,J Carlos Angel ,Caitlin Brown ,Zhen Dong ,Natasha Jansz ,Fabio Puddu ,Aurélie Modat ,Jamie Scotcher ,Páidí Creed ,Patrick H Kennedy ,Cindy Manriquez-Rodriguez ,Samuel A Myers ,Robert Crawford ,Geoffrey J Faulkner ,Anjana Rao

Establishing a physiologically based pharmacokinetic framework for aldehyde oxidase and dual aldehyde oxidase-CYP substrates

建立醛氧化酶和双重醛氧化酶-CYP底物的生理药代动力学框架

Izat, Nihan; Bolleddula, Jayaprakasam; Carione, Pasquale; Huertas Valentin, Leticia; Jones, Robert S; Kulkarni, Priyanka; Moss, Darren; Peterkin, Vincent C; Tian, Dan-Dan; Treyer, Andrea; Venkatakrishnan, Karthik; Zientek, Michael A; Barber, Jill; Houston, J Brian; Galetin, Aleksandra; Scotcher, Daniel

Evaluation of Adefovir PBPK Model to Assess Biomarker-Informed OAT1 Drug-Drug Interaction and Effect of Chronic Kidney Disease

利用生物标志物指导的阿德福韦PBPK模型评估OAT1药物相互作用及慢性肾脏病的影响

Tan, Shawn Pei Feng; Wu, Huaying; Rostami-Hodjegan, Amin; Scotcher, Daniel; Galetin, Aleksandra

Genotype, Ethnicity, and Drug-Drug Interaction Modeling as Means of Verifying Transporter Biomarker PBPK Model: The Coproporphyrin-I Story

基因型、种族和药物相互作用建模作为验证转运体生物标志物PBPK模型的方法:以粪卟啉-I为例

Ujihira, Yuki; Tan, Shawn Pei Feng; Scotcher, Daniel; Galetin, Aleksandra

Albumin-Mediated Drug Uptake by Organic Anion Transporter 1/3 Is Real: Implications for the Prediction of Active Renal Secretion Clearance

有机阴离子转运体 1/3 介导白蛋白药物吸收是真实存在的:对预测主动肾分泌清除率的意义

Shawn Pei Feng Tan, Annika Tillmann, Susan J Murby, Amin Rostami-Hodjegan, Daniel Scotcher, Aleksandra Galetin

Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug-Drug Interactions in Rats

利用体内成像和基于生理学的动力学模型预测大鼠肝脏转运蛋白介导的药物相互作用

Melillo, Nicola; Scotcher, Daniel; Kenna, J Gerry; Green, Claudia; Hines, Catherine D G; Laitinen, Iina; Hockings, Paul D; Ogungbenro, Kayode; Gunwhy, Ebony R; Sourbron, Steven; Waterton, John C; Schuetz, Gunnar; Galetin, Aleksandra

Using Prior Knowledge on Systems Through PBPK to Gain Further Insight into Routine Clinical Data on Trough Concentrations: The Case of Tacrolimus in Chronic Kidney Disease

利用生理药代动力学(PBPK)对系统已有知识的理解,进一步深入了解谷浓度常规临床数据:以慢性肾脏病患者使用他克莫司为例

El-Khateeb, Eman; Chinnadurai, Rajkumar; Al Qassabi, Jokha; Scotcher, Daniel; Darwich, Adam S; Kalra, Philip A; Rostami-Hodjegan, Amin

Integrated fecal microbiome-metabolome signatures reflect stress and serotonin metabolism in irritable bowel syndrome

综合粪便微生物组代谢组特征反映肠易激综合征中的压力和血清素代谢

Zlatan Mujagic, Melpomeni Kasapi, Daisy Mae Jonkers, Isabel Garcia-Perez, Lisa Vork, Zsa Zsa R M Weerts, Jose Ivan Serrano-Contreras, Alexandra Zhernakova, Alexander Kurilshikov, Jamie Scotcher, Elaine Holmes, Cisca Wijmenga, Daniel Keszthelyi, Jeremy K Nicholson, Joram M Posma, Ad Am Masclee