日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

基于 DCAF1 的 PROTAC 具有针对临床验证靶标的活性,可克服内在和获得性降解剂耐药性

Martin Schröder #, Martin Renatus #, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pi

A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes

使用亲电探针评估 E3 连接酶成分针对新底物的细胞活性的策略

Benika J Pinch, Dennis L Buckley, Scott Gleim, Scott M Brittain, Laura Tandeske, Pier Luca D'Alessandro, Zachary J Hauseman, Jennifer Lipps, Lei Xu, Edward P Harvey, Markus Schirle, Elizabeth R Sprague, William C Forrester, Dustin Dovala, Lynn M McGregor, Claudio R Thoma

CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism

CYP27A1 依赖的柠檬苦素类天然产物的抗黑色素瘤活性靶向线粒体代谢

Hyelim Cho, Qiong Shen, Lydia H Zhang, Mikiko Okumura, Akinori Kawakami, Jessi Ambrose, Frederic Sigoillot, Howard R Miller, Scott Gleim, Amanda Cobos-Correa, Ying Wang, Philippe Piechon, Guglielmo Roma, Fabian Eggimann, Charles Moore, Peter Aspesi Jr, Felipa A Mapa, Heather Burks, Nathan T Ross, Ph

CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma

CPSF3依赖性前体mRNA加工是急性髓系白血病和尤文氏肉瘤中可作为药物靶点的节点

Nathan T Ross # ,Felix Lohmann # ,Seth Carbonneau ,Aleem Fazal ,Wilhelm A Weihofen ,Scott Gleim ,Michael Salcius ,Frederic Sigoillot ,Martin Henault ,Sarah H Carl ,Juan B Rodríguez-Molina ,Howard R Miller ,Scott M Brittain ,Jason Murphy ,Mark Zambrowski ,Geoffrey Boynton ,Yuan Wang ,Aye Chen ,Gregory J Molind ,Johannes H Wilbertz ,Caroline G Artus-Revel ,Min Jia ,Favour A Akinjiyan ,Jonathan Turner ,Judith Knehr ,Walter Carbone ,Sven Schuierer ,John S Reece-Hoyes ,Kevin Xie ,Chitra Saran ,Eric T Williams ,Guglielmo Roma ,Matt Spencer ,Jeremy Jenkins ,Elizabeth L George ,Jason R Thomas ,Gregory Michaud ,Markus Schirle ,John Tallarico ,Lori A Passmore ,Jeffrey A Chao ,Rohan E J Beckwith #

Identification of the HECT E3 ligase UBR5 as a regulator of MYC degradation using a CRISPR/Cas9 screen

利用 CRISPR/Cas9 筛选鉴定 HECT E3 连接酶 UBR5 为 MYC 降解的调节因子

Lina Schukur ,Tamara Zimmermann ,Ole Niewoehner ,Grainne Kerr ,Scott Gleim ,Beatrice Bauer-Probst ,Britta Knapp ,Giorgio G Galli ,Xiaoyou Liang ,Angelica Mendiola ,John Reece-Hoyes ,Melivoia Rapti ,Ines Barbosa ,Markus Reschke ,Thomas Radimerski ,Claudio R Thoma

Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C

妇科癌症中反复出现的泛素 B 沉默确立了对泛素 C 的依赖

Alexia T Kedves, Scott Gleim, Xiaoyou Liang, Dennis M Bonal, Frederic Sigoillot, Fred Harbinski, Sneha Sanghavi, Christina Benander, Elizabeth George, Prafulla C Gokhale, Quang-De Nguyen, Paul T Kirschmeier, Robert J Distel, Jeremy Jenkins, Michael S Goldberg, William C Forrester

Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition

mTORC1 抑制后,GATA-6 磷酸化是血管平滑肌细胞分化的必要条件

Yi Xie, Yu Jin, Bethany L Merenick, Min Ding, Kristina M Fetalvero, Robert J Wagner, Alice Mai, Scott Gleim, David F Tucker, Morris J Birnbaum, Bryan A Ballif, Amelia K Luciano, William C Sessa, Eva M Rzucidlo, Richard J Powell, Lin Hou, Hongyu Zhao, John Hwa, Jun Yu, Kathleen A Martin

Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets

醛糖还原酶介导的 p53 磷酸化导致糖尿病血小板线粒体功能障碍和损伤

Wai Ho Tang, Jeremiah Stitham, Yu Jin, Renjing Liu, Seung Hee Lee, Jing Du, Gourg Atteya, Scott Gleim, Geralyn Spollett, Kathleen Martin, John Hwa

Biased suppression of TP homodimerization and signaling through disruption of a TM GxxxGxxxL helical interaction motif

通过破坏 TM GxxxGxxxL 螺旋相互作用基序来偏向抑制 TP 同源二聚化和信号传导

Alexander J Frey, Salam Ibrahim, Scott Gleim, John Hwa, Emer M Smyth

New insights into structural determinants for prostanoid thromboxane A2 receptor- and prostacyclin receptor-G protein coupling

对前列腺素类血栓素 A2 受体和前列环素受体 G 蛋白偶联的结构决定因素的新见解

Raja Chakraborty, Sai Prasad Pydi, Scott Gleim, Rajinder Pal Bhullar, John Hwa, Shyamala Dakshinamurti, Prashen Chelikani