日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

De novo design of peptide binders to conformationally diverse targets with contrastive language modeling

利用对比语言模型对构象不同的靶标进行肽结合剂的从头设计

Suhaas Bhat, Kalyan Palepu, Lauren Hong, Joey Mao, Tianzheng Ye, Rema Iyer, Lin Zhao, Tianlai Chen, Sophia Vincoff, Rio Watson, Tian Z Wang, Divya Srijay, Venkata Srikar Kavirayuni, Kseniia Kholina, Shrey Goel, Pranay Vure, Aniruddha J Deshpande, Scott H Soderling, Matthew P DeLisa, Pranam Chatterje

Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions

对天然蛋白质组的邻近分析揭示了自闭症及相关神经发育障碍小鼠模型中的表型修饰因子

Yudong Gao ,Daichi Shonai ,Matthew Trn ,Jieqing Zhao ,Erik J Soderblom ,S Alexandra Garcia-Moreno ,Charles A Gersbach ,William C Wetsel ,Geraldine Dawson ,Dmitry Velmeshev ,Yong-Hui Jiang ,Laura G Sloofman ,Joseph D Buxbaum ,Scott H Soderling

Astrocytic LRRK2 Controls Synaptic Connectivity via Regulation of ERM Phosphorylation

星形胶质细胞 LRRK2 通过调节 ERM 磷酸化来控制突触连接

Shiyi Wang, Ryan Baumert, Gabrielle Séjourné, Dhanesh Sivadasan Bindu, Kylie Dimond, Kristina Sakers, Leslie Vazquez, Jessica Moore, Christabel Xin Tan, Tetsuya Takano, Maria Pia Rodriguez, Scott H Soderling, Albert R La Spada, Cagla Eroglu

De Novo Design of Peptide Binders to Conformationally Diverse Targets with Contrastive Language Modeling

使用对比语言模型对构象多样的靶标进行肽结合剂的从头设计

Suhaas Bhat, Kalyan Palepu, Lauren Hong, Joey Mao, Tianzheng Ye, Rema Iyer, Lin Zhao, Tianlai Chen, Sophia Vincoff, Rio Watson, Tian Wang, Divya Srijay, Venkata Srikar Kavirayuni, Kseniia Kholina, Shrey Goel, Pranay Vure, Aniruddha J Desphande, Scott H Soderling, Matthew P DeLisa, Pranam Chatterjee

Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control

训练诱导的小鼠电路特异性兴奋性突触形成是努力控制的必要条件

Francesco Paolo Ulloa Severino #, Oluwadamilola O Lawal #, Kristina Sakers, Shiyi Wang, Namsoo Kim, Alexander David Friedman, Sarah Anne Johnson, Chaichontat Sriworarat, Ryan H Hughes, Scott H Soderling, Il Hwan Kim, Henry H Yin, Cagla Eroglu

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders

识别大脑中新的纤毛信号通路并深入了解神经系统疾病

Abdelhalim Loukil, Emma Ebright, Akiyoshi Uezu, Yudong Gao, Scott H Soderling, Sarah C Goetz

Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans

WASHC4基因的破坏会导致小鼠和人类的内溶酶体功能障碍和认知运动障碍。

Jamie L Courtland # ,Tyler Wa Bradshaw # ,Greg Waitt ,Erik J Soderblom ,Tricia Ho ,Anna Rajab ,Ricardo Vancini ,Il Hwan Kim ,Scott H Soderling

Action potential-coupled Rho GTPase signaling drives presynaptic plasticity

动作电位偶联的Rho GTP酶信号传导驱动突触前可塑性

Shataakshi Dube O'Neil ,Bence Rácz ,Walter Evan Brown ,Yudong Gao ,Erik J Soderblom ,Ryohei Yasuda ,Scott H Soderling

Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome

小鼠中 Cnksr2 缺失导致神经活动增强和癫痫-失语综合征的行为表型

Eda Erata ,Yudong Gao ,Alicia M Purkey ,Erik J Soderblom ,James O McNamara ,Scott H Soderling

Chemico-genetic discovery of astrocytic control of inhibition in vivo

化学遗传学发现星形胶质细胞控制体内抑制

Tetsuya Takano, John T Wallace, Katherine T Baldwin, Alicia M Purkey, Akiyoshi Uezu, Jamie L Courtland, Erik J Soderblom, Tomomi Shimogori, Patricia F Maness, Cagla Eroglu, Scott H Soderling