日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1

在 CACHE Challenge #1 中,FRASE-bot 鉴定出了靶向 LRRK2 WD40 重复结构域的功能活性调节因子。

Akhila Mettu,Marta Glavatskikh,Xiaowen Wang,Antonio Jesús Lara Ordóñez,Fengling Li,Irene Chau,Suzanne Ackloo,Cheryl Arrowsmith,Albina Bolotokova,Pegah Ghiabi,Elisa Gibson,Levon Halabelian,Scott Houliston,Rachel J Harding,Ashley Hutchinson,Peter Loppnau,Sumera Perveen,Almagul Seitova,Hong Zeng,Matthieu Schapira,Jean-Marc Taymans,Dmitri Kireev

The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase

MYC 癌蛋白直接与其染色质辅因子 PNUTS 相互作用,从而募集 PP1 磷酸酶

Yong Wei, Cornelia Redel, Alexandra Ahlner, Alexander Lemak, Isak Johansson-Åkhe, Scott Houliston, Tristan M G Kenney, Aaliya Tamachi, Vivian Morad, Shili Duan, David W Andrews, Björn Wallner, Maria Sunnerhagen, Cheryl H Arrowsmith, Linda Z Penn

The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase

MYC癌蛋白直接与其染色质辅助因子PNUTS相互作用,从而募集PP1磷酸酶。

Yong Wei ,Cornelia Redel,Alexandra Ahlner,Alexander Lemak,Isak Johansson-Åkhe,Scott Houliston,Tristan M G Kenney,Aaliya Tamachi,Vivian Morad,Shili Duan, David W Andrews,Björn Wallner,Maria Sunnerhagen,Cheryl H Arrowsmith ,Linda Z Penn

De novo design of immunoglobulin-like domains

免疫球蛋白样结构域的从头设计

Tamuka M Chidyausiku #, Soraia R Mendes #, Jason C Klima, Marta Nadal, Ulrich Eckhard, Jorge Roel-Touris, Scott Houliston, Tibisay Guevara, Hugh K Haddox, Adam Moyer, Cheryl H Arrowsmith, F Xavier Gomis-Rüth, David Baker, Enrique Marcos

Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1

可变剪接和变构调控调节 UHRF1 的染色质结合

Maria Tauber, Sarah Kreuz, Alexander Lemak, Papita Mandal, Zhadyra Yerkesh, Alaguraj Veluchamy, Bothayna Al-Gashgari, Abrar Aljahani, Lorena V Cortés-Medina, Dulat Azhibek, Lixin Fan, Michelle S Ong, Shili Duan, Scott Houliston, Cheryl H Arrowsmith, Wolfgang Fischle

Discovery of Ubiquitin Deamidases in the Pathogenic Arsenal of Legionella pneumophila

在嗜肺军团菌的致病武器库中发现泛素脱酰胺酶

Dylan Valleau, Andrew T Quaile, Hong Cui, Xiaohui Xu, Elena Evdokimova, Changsoo Chang, Marianne E Cuff, Malene L Urbanus, Scott Houliston, Cheryl H Arrowsmith, Alexander W Ensminger, Alexei Savchenko

Solution NMR structure and histone binding of the PHD domain of human MLL5

人类 MLL5 的 PHD 结构域的溶液 NMR 结构和组蛋白结合

Alexander Lemak, Adelinda Yee, Hong Wu, Damian Yap, Hong Zeng, Ludmila Dombrovski, Scott Houliston, Samuel Aparicio, Cheryl H Arrowsmith

Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation

UHRF1 串联 Tudor 和 PHD 结构域的多价组蛋白结合是 DNA 甲基化的表观遗传所必需的

Scott B Rothbart, Bradley M Dickson, Michelle S Ong, Krzysztof Krajewski, Scott Houliston, Dmitri B Kireev, Cheryl H Arrowsmith, Brian D Strahl