日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pharmacokinetics and Safety of Selumetinib Granule Formulation in Children With Symptomatic, Inoperable Neurofibromatosis Type 1-Related Plexiform Neurofibromas (SPRINKLE; phase I/II)

Selumetinib颗粒剂治疗有症状、无法手术的1型神经纤维瘤病相关丛状神经纤维瘤患儿的药代动力学和安全性研究(SPRINKLE;I/II期)

Hernáiz Driever, Pablo; Kordes, Uwe R; Brecht, Ines B; Saletti, Veronica; Fisher, Michael J; Doughton, Gail; Arefayene, Million; Rigazio, Anna; Lluch, Nuria; Llorente, Nereida; Diede, Scott J; Salvador, Hector

Same-Slide Spatial Multi-Omics Integration with IN-DEPTH Reveals Tumor Virus-Linked Spatial Reorganization of the Tumor Microenvironment.

通过 IN-DEPTH 进行同一张载玻片空间多组学整合,揭示了肿瘤病毒相关的肿瘤微环境空间重组。

Yiu Stephanie Pei Tung, Chang Yuzhou, Yeo Yao Yu, Qiu Huaying, Wu Wenrui, Michel Hendrik A, Jin Xiaojie, Huang Rongting, Kure Shoko, Parmelee Lindsay, Luo Shuli, Cramer Precious, Lee Jia Le, Wang Yang, Zhao Zhangxin, Yeung Jason, El Ahmar Nourhan, Simsek Berkay, Mohanna Razan, Van Orden McKayla, Lu Wesley S, Livak Kenneth J, Li Shuqiang, Gao Ce, Burgess Melinda, Keane Colm, Shahryari Jahanbanoo, Kingsley Leandra G, Al-Humadi Reem N, Nasr Sahar, Nkosi Dingani, Sadigh Sam, Rock Philip, Frauenfeld Leonie, Kaufmann Louisa, Zhu Bokai, Basak Ankit, Dhanikonda Nagendra, Chan Chi Ngai, Krull Jordan, Cho Ye Won, Chen Chia-Yu, Brown Jonathan, Wang Hongbo, Zhao Bo, Lee Jia-Ying Joey, Loo Lit-Hsin, Kim David M, Boussiotis Vassiliki A, Zhang Baochun, Wei Kevin, Shalek Alex K, Howitt Brooke E, Signoretti Sabina, Schürch Christian M, Hodi F Stephen, Burack W Richard, Rodig Scott J, Ma Qin, Jiang Sizun

Distinct Tumor-Immune Ecologies in Patients with Lung Cancer Predict Progression and Define a Clinical Biomarker of Therapy Response

肺癌患者中不同的肿瘤免疫生态可预测疾病进展并确定治疗反应的临床生物标志物。

Prabhakaran, Sandhya; Gatenbee, Chandler D; Robertson-Tessi, Mark; Gahramanli Ozturk, Zarifa; Boyle, Theresa A; Gray, Jhanelle E; Antonia, Scott J; Gatenby, Robert A; Beg, Amer A; Anderson, Alexander R A

Climate impacts from North American boreal forest fires

北美北方森林火灾对气候的影响

van Gerrevink, Max J; Veraverbeke, Sander; Cooperdock, Sol; Potter, Stefano; Zhong, Qirui; Moubarak, Michael; Virkkala, Anna-Maria; Goetz, Scott J; Mack, Michelle C; Randerson, James T; Schutgens, Nick; Turetsky, Merritt R; van der Werf, Guido R; Rogers, Brendan M

Asymmetric Desymmetrizing Sulfonylation of Diarylmethanes via Peptidyl-Cu(I)-Catalysis with Remote Stereocontrol

利用肽基-Cu(I)催化实现二芳基甲烷的不对称去对称磺酰化反应及其远程立体控制

Um, Hyun-Suk; Miller, Scott J

Asymmetric Hydrogen Atom Transfer

不对称氢原子转移

Feng, Andrew G; Pinto Pereira Junior, Marcus Vinicius; Miller, Scott J; Knowles, Robert R

Progressive neuroinflammation and deficits in motor function in a mouse model with an Epg5 pathogenic variant of Vici syndrome

在携带Vici综合征Epg5致病变异的小鼠模型中,出现进行性神经炎症和运动功能障碍。

Thornton, Bradley T; Hardinger, Alexandra G; Pence, Laramie; Kumar, Priyanka Prem; Connolly, Nikolas; Weir, Scott J; Vivian, Jay L

Dual targeting of BRAF(V600E) and ferroptosis results in synergistic anticancer activity via iron overload and enhanced oxidative stress.

BRAF(V600E) 和铁死亡的双重靶向作用通过铁过载和增强氧化应激产生协同抗癌活性。

Hu Jiangnan, Ghosh Chandrayee, Khaket Tejinder P, Yang Zhongyue, Tabdili Yasmine, Alamaw Eden D, Boufraqech Myriem, Dixon Scott J, Kebebew Electron

Inhibition of GluN2B-containing N-methyl-D-aspartate receptors by radiprodil.

雷迪普罗地尔对含 GluN2B 的 N-甲基-D-天冬氨酸受体的抑制作用。

Banke Tue G, Regan Michael C, Perszyk Riley E, Zhang Lu, Xing Hao, Chen Jiahui, Won Sehoon, Simorowski Noriko, Diaz Eva S, Kim Sukhan, Song Rui, Rong Jian, Zhou Xin, Chaudhary Ahmad F, Zhang Jing, Traynelis John F, McDaniels Ellington D, Nitsche Karolina, Roache Steve, Raymond Christopher S, Low Chian-Ming, Myers Scott J, Roche Katherine W, Liang Steven H, Traynelis Stephen F, Furukawa Hiro, Yuan Hongjie

The Yeh pilus adhesin is equipped with an α-helical flap motif, which contributes to pectin adherence

叶菌毛粘附素具有α螺旋瓣状结构,有助于果胶粘附。

Kevin O Tamadonfar,Roger D Klein,Edward D B Lopatto,Maxwell I Zimmerman,Philippe N Azimzadeh,Denise A Sanick,Justin R Porter,Jesus Bazan Villicana,Jerome S Pinkner,Bo Huey Chiang,Nathaniel C Gualberto,Karen W Dodson,Michael L Patnode,George M H Birchenough,Gregory R Bowman,Scott J Hultgren