日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition

免疫检查点抑制剂对人类黑色素瘤脑转移微环境的影响

Christopher Alvarez-Breckenridge # ,Samuel C Markson # ,Jackson H Stocking ,Naema Nayyar ,Matt Lastrapes ,Matthew R Strickland ,Albert E Kim ,Magali de Sauvage ,Ashish Dahal ,Juliana M Larson ,Joana L Mora ,Andrew W Navia ,Robert H Klein ,Benjamin M Kuter ,Corey M Gill ,Mia Bertalan ,Brian Shaw ,Alexander Kaplan ,Megha Subramanian ,Aarushi Jain ,Swaminathan Kumar ,Husain Danish ,Michael White ,Osmaan Shahid ,Kristen E Pauken ,Brian C Miller ,Dennie T Frederick ,Christine Hebert ,McKenzie Shaw ,Maria Martinez-Lage ,Matthew Frosch ,Nancy Wang ,Elizabeth Gerstner ,Brian V Nahed ,William T Curry ,Bob Carter ,Daniel P Cahill ,Genevieve Marie Boland ,Benjamin Izar ,Michael A Davies ,Arlene H Sharpe ,Mario L Suvà ,Ryan J Sullivan ,Priscilla K Brastianos # ,Scott L Carter #

Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade

Fbxw7 失活会损害 dsRNA 感应并产生对 PD-1 阻断的抵抗力

Cécile Gstalder, David Liu, Diana Miao, Bart Lutterbach, Alexander L DeVine, Chenyu Lin, Megha Shettigar, Priya Pancholi, Elizabeth I Buchbinder, Scott L Carter, Michael P Manos, Vanesa Rojas-Rudilla, Ryan Brennick, Evisa Gjini, Pei-Hsuan Chen, Ana Lako, Scott Rodig, Charles H Yoon, Gordon J Freeman

Targeting the PI3K/Akt/mTOR pathway with the pan-Akt inhibitor GDC-0068 in PIK3CA-mutant breast cancer brain metastases

使用泛 Akt 抑制剂 GDC-0068 靶向 PI3K/Akt/mTOR 通路治疗 PIK3CA 突变乳腺癌脑转移

Franziska Maria Ippen, Julia Katharina Grosch, Megha Subramanian, Benjamin Macfarlane Kuter, Bianca M Liederer, Emile G Plise, Joana Liliana Mora, Naema Nayyar, Stephen Paul Schmidt, Anita Giobbie-Hurder, Maria Martinez-Lage, Scott L Carter, Daniel P Cahill, Hiroaki Wakimoto, Priscilla Kaliopi Brast

The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases

双 PI3K/mTOR 通路抑制剂 GDC-0084 在 PIK3CA 突变乳腺癌脑转移中发挥抗肿瘤活性

Franziska M Ippen, Christopher A Alvarez-Breckenridge, Benjamin M Kuter, Alexandria L Fink, Ivanna V Bihun, Matthew Lastrapes, Tristan Penson, Stephen P Schmidt, Gregory R Wojtkiewicz, Jianfang Ning, Megha Subramanian, Anita Giobbie-Hurder, Maria Martinez-Lage, Scott L Carter, Daniel P Cahill, Hiroa

Genomic Resistance Patterns to Second-Generation Androgen Blockade in Paired Tumor Biopsies of Metastatic Castration-Resistant Prostate Cancer

转移性去势抵抗性前列腺癌配对肿瘤活检样本中对第二代雄激素阻断剂的基因组耐药模式

G Celine Han, Justin Hwang, Stephanie A M Wankowicz, Zhenwei Zhang, David Liu, Carrie Cibulskis, Glenn C Gaviola, Varand Ghazikhanian, Rana R McKay, Glenn J Bubley, Scott L Carter, Steven P Balk, William C Hahn, Mary-Ellen Taplin, Eliezer M Van Allen

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition

慢性淋巴细胞白血病患者对BTK抑制剂产生耐药性的克隆演变

Jan A Burger ,Dan A Landau ,Amaro Taylor-Weiner ,Ivana Bozic ,Huidan Zhang ,Kristopher Sarosiek ,Lili Wang ,Chip Stewart ,Jean Fan ,Julia Hoellenriegel ,Mariela Sivina ,Adrian M Dubuc ,Cameron Fraser ,Yulong Han ,Shuqiang Li ,Kenneth J Livak ,Lihua Zou ,Youzhong Wan ,Sergej Konoplev ,Carrie Sougnez ,Jennifer R Brown ,Lynne V Abruzzo ,Scott L Carter ,Michael J Keating ,Matthew S Davids ,William G Wierda ,Kristian Cibulskis ,Thorsten Zenz ,Lillian Werner ,Paola Dal Cin ,Peter Kharchencko ,Donna Neuberg ,Hagop Kantarjian ,Eric Lander ,Stacey Gabriel ,Susan O'Brien ,Anthony Letai ,David A Weitz ,Martin A Nowak ,Gad Getz ,Catherine J Wu

Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine

福尔马林固定石蜡包埋肿瘤样本的全外显子组测序和临床解读,以指导精准癌症医学

Eliezer M Van Allen, Nikhil Wagle, Petar Stojanov, Danielle L Perrin, Kristian Cibulskis, Sara Marlow, Judit Jane-Valbuena, Dennis C Friedrich, Gregory Kryukov, Scott L Carter, Aaron McKenna, Andrey Sivachenko, Mara Rosenberg, Adam Kiezun, Douglas Voet, Michael Lawrence, Lee T Lichtenstein, Jeff G G

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

互补基因组学方法强调 PI3K/mTOR 通路是骨肉瘤的常见弱点

Jennifer A Perry, Adam Kiezun, Peter Tonzi, Eliezer M Van Allen, Scott L Carter, Sylvan C Baca, Glenn S Cowley, Ami S Bhatt, Esther Rheinbay, Chandra Sekhar Pedamallu, Elena Helman, Amaro Taylor-Weiner, Aaron McKenna, David S DeLuca, Michael S Lawrence, Lauren Ambrogio, Carrie Sougnez, Andrey Sivach

Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity

食管腺癌的外显子组和全基因组测序确定了复发性驱动事件和突变复杂性

Austin M Dulak, Petar Stojanov, Shouyong Peng, Michael S Lawrence, Cameron Fox, Chip Stewart, Santhoshi Bandla, Yu Imamura, Steven E Schumacher, Erica Shefler, Aaron McKenna, Scott L Carter, Kristian Cibulskis, Andrey Sivachenko, Gordon Saksena, Douglas Voet, Alex H Ramos, Daniel Auclair, Kristin Th

Inferring tumour purity and stromal and immune cell admixture from expression data

从表达数据推断肿瘤纯度以及基质细胞和免疫细胞的混合情况

Kosuke Yoshihara ,Maria Shahmoradgoli, Emmanuel Martínez, Rahulsimham Vegesna, Hoon Kim, Wandaliz Torres-Garcia, Victor Treviño, Hui Shen, Peter W Laird, Douglas A Levine, Scott L Carter, Gad Getz, Katherine Stemke-Hale, Gordon B Mills, Roel G W Verhaak