日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease

利用多组学数据进行变革性网络建模,揭示阿尔茨海默病的详细回路、关键调控因子和潜在疗法

Minghui Wang ,Aiqun Li ,Michiko Sekiya ,Noam D Beckmann ,Xiuming Quan ,Nadine Schrode ,Michael B Fernando ,Alex Yu ,Li Zhu ,Jiqing Cao ,Liwei Lyu ,Emrin Horgusluoglu ,Qian Wang ,Lei Guo ,Yuan-Shuo Wang ,Ryan Neff ,Won-Min Song ,Erming Wang ,Qi Shen ,Xianxiao Zhou ,Chen Ming ,Seok-Man Ho ,Sezen Vatansever ,H Ümit Kaniskan ,Jian Jin ,Ming-Ming Zhou ,Kanae Ando ,Lap Ho ,Paul A Slesinger ,Zhenyu Yue ,Jun Zhu ,Pavel Katsel ,Sam Gandy ,Michelle E Ehrlich ,Valentina Fossati ,Scott Noggle ,Dongming Cai ,Vahram Haroutunian ,Koichi M Iijima ,Eric Schadt ,Kristen J Brennand ,Bin Zhang

Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors

干细胞衍生的神经元反映了其老年人类供体的蛋白质网络、神经病理学和认知结果的特征。

Valentina N Lagomarsino ,Richard V Pearse 2nd ,Lei Liu ,Yi-Chen Hsieh ,Marty A Fernandez ,Elizabeth A Vinton ,Daniel Paull ,Daniel Felsky ,Shinya Tasaki ,Chris Gaiteri ,Badri Vardarajan ,Hyo Lee ,Christina R Muratore ,Courtney R Benoit ,Vicky Chou ,Seeley B Fancher ,Amy He ,Julie P Merchant ,Duc M Duong ,Hector Martinez ,Monica Zhou ,Fatmata Bah ,Maria A Vicent ,Jonathan M S Stricker ,Jishu Xu ,Eric B Dammer ,Allan I Levey ,Lori B Chibnik ,Vilas Menon ,Nicholas T Seyfried ,Philip L De Jager ,Scott Noggle ,Dennis J Selkoe ,David A Bennett ,Tracy L Young-Pearse

Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells

植入前和植入前后寨卡病毒感染通过靶向滋养外胚层细胞损害胎儿发育

Lei Tan, Lauretta A Lacko, Ting Zhou, Delia Tomoiaga, Romulo Hurtado, Tuo Zhang, Ana Sevilla, Aaron Zhong, Christopher E Mason, Scott Noggle, Todd Evans, Heidi Stuhlmann, Robert E Schwartz, Shuibing Chen

Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer's Disease iPSC-Derived Neural Stem Cells

贝沙罗汀诱导自噬可促进早老素 1 家族性阿尔茨海默病 iPSC 衍生神经干细胞中的线粒体自噬

Patricia Martín-Maestro, Andrew Sproul, Hector Martinez, Dominik Paquet, Meri Gerges, Scott Noggle, Anatoly A Starkov

iPSC-derived familial Alzheimer's PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling

iPSC 衍生的家族性阿尔茨海默氏症 PSEN2 N141I 胆碱能神经元表现出突变依赖性分子病理,可通过胰岛素信号传导进行纠正

Cesar L Moreno, Lucio Della Guardia, Valeria Shnyder, Maitane Ortiz-Virumbrales, Ilya Kruglikov, Bin Zhang, Eric E Schadt, Rudolph E Tanzi, Scott Noggle, Christoph Buettner, Sam Gandy

Derivation and characterization of the NIH registry human stem cell line NYSCF101 under defined feeder-free conditions

在规定的无饲养层条件下衍生和表征 NIH 注册人类干细胞系 NYSCF101

Ana Sevilla, Eliana Forero, Matthew Zimmer, Hector Martinez, Katie Reggio, Daniel Paull, Dieter Egli, Scott Noggle

Derivation and characterization of the NIH registry human stem cell line NYSCF100 line under defined feeder-free conditions

在规定的无饲养层条件下衍生和表征 NIH 注册人类干细胞系 NYSCF100

Ana Sevilla, Eliana Forero, Matthew Zimmer, Hector Martinez, Katie Reggio, Daniel Paull, Dieter Egli, Scott Noggle

CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons

iPSC 衍生的阿尔茨海默病 PSEN2 N141I 神经元中 CRISPR/Cas9 可校正突变相关分子和生理表型

Maitane Ortiz-Virumbrales, Cesar L Moreno, Ilya Kruglikov, Paula Marazuela, Andrew Sproul, Samson Jacob, Matthew Zimmer, Daniel Paull, Bin Zhang, Eric E Schadt, Michelle E Ehrlich, Rudolph E Tanzi, Ottavio Arancio, Scott Noggle, Sam Gandy2

Directed Differentiation of Human Pluripotent Stem Cells to Microglia

人类多能干细胞定向分化为小胶质细胞

Panagiotis Douvaras, Bruce Sun, Minghui Wang, Ilya Kruglikov, Gregory Lallos, Matthew Zimmer, Cecile Terrenoire, Bin Zhang, Sam Gandy, Eric Schadt, Donald O Freytes, Scott Noggle, Valentina Fossati

Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation

阿尔茨海默病相关早老素 1 突变的成纤维细胞和 iPSC 衍生神经元中的线粒体自噬失败

Patricia Martín-Maestro, Ricardo Gargini, Andrew A Sproul, Esther García, Luis C Antón, Scott Noggle, Ottavio Arancio, Jesús Avila, Vega García-Escudero