日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure of phosphorylated-like RssB, the adaptor delivering σs to the ClpXP proteolytic machinery, reveals an interface switch for activation

磷酸化样 RssB 的结构,即向 ClpXP 蛋白水解机制提供 σs 的适配器,揭示了用于激活的界面开关

Christiane Brugger, Jacob Schwartz, Scott Novick, Song Tong, Joel R Hoskins, Nadim Majdalani, Rebecca Kim, Martin Filipovski, Sue Wickner, Susan Gottesman, Patrick R Griffin, Alexandra M Deaconescu

Dual-mechanism estrogen receptor inhibitors

双机制雌激素受体抑制剂

Jian Min, Jerome C Nwachukwu, Charles K Min, Jacqline W Njeri, Sathish Srinivasan, Erumbi S Rangarajan, Charles C Nettles, Valeria Sanabria Guillen, Yvonne Ziegler, Shunchao Yan, Kathryn E Carlson, Yingwei Hou, Sung Hoon Kim, Scott Novick, Bruce D Pascal, Rene Houtman, Patrick R Griffin, Tina Izard,

Full antagonism of the estrogen receptor without a prototypical ligand side chain

无需原型配体侧链即可完全拮抗雌激素受体

Sathish Srinivasan, Jerome C Nwachukwu, Nelson E Bruno, Venkatasubramanian Dharmarajan, Devrishi Goswami, Irida Kastrati, Scott Novick, Jason Nowak, Valerie Cavett, Hai-Bing Zhou, Nittaya Boonmuen, Yuechao Zhao, Jian Min, Jonna Frasor, Benita S Katzenellenbogen, Patrick R Griffin, John A Katzenellen

Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA

配体和 DNA 对辅调节剂/核受体相互作用的协同调节

Ian Mitchelle S de Vera, Jie Zheng, Scott Novick, Jinsai Shang, Travis S Hughes, Richard Brust, Paola Munoz-Tello, William J Gardner Jr, David P Marciano, Xiangming Kong, Patrick R Griffin, Douglas J Kojetin

Nitric oxide-induced conformational changes in soluble guanylate cyclase

一氧化氮诱导的可溶性鸟苷酸环化酶构象变化

Eric S Underbakke, Anthony T Iavarone, Michael J Chalmers, Bruce D Pascal, Scott Novick, Patrick R Griffin, Michael A Marletta

Osh4p is needed to reduce the level of phosphatidylinositol-4-phosphate on secretory vesicles as they mature

Osh4p对于降低分泌囊泡成熟过程中其表面磷脂酰肌醇-4-磷酸的水平是必需的。

Ling, Yading; Hayano, Scott; Novick, Peter

Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism

配体和受体动力学有助于 PPARγ 分级激动机制

Travis S Hughes, Michael J Chalmers, Scott Novick, Dana S Kuruvilla, Mi Ra Chang, Theodore M Kamenecka, Mark Rance, Bruce A Johnson, Thomas P Burris, Patrick R Griffin, Douglas J Kojetin