日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An oral heme oxygenase inhibitor targets immunosuppressive perivascular macrophages in preclinical models of cancer.

口服血红素加氧酶抑制剂靶向癌症临床前模型中的免疫抑制性血管周围巨噬细胞

Bahri Meriem, Al-Adhami Taha, Demirel Emre, Sarkar Jit, Feehan Karen T, Anstee Joanne E, Cheung Tik Shing, Sosnowska Dominika, Woodman Chloé A, Macmorland William, Yang Dorothy D, Rosekilly James, Gitsaki-Taylor Renee, Gillett Cheryl E, Scudamore Cheryl L, Spicer James, Rahman Khondaker Miraz, Arnold James N

Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock.

PI3K-C2α失活会扰乱细胞死亡途径,并使细胞对内毒素休克更加敏感

Posor York, Conduit Sarah E, Pearce Wayne, Morelli Daniele, Constantinou Georgia, Whitehead Maria, Sebire Neil J, Scudamore Cheryl L, Peltzer Nieves, Walczak Henning, Vanhaesebroeck Bart

Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development.

调节性 T 细胞中缺乏磷脂酰肌醇 3-激酶 VPS34 会导致致命的淋巴增生性疾病,但并不影响其发育

Courreges Christina J F, Davenport Elizabeth C M, Bilanges Benoit, Rebollo-Gomez Elena, Hukelmann Jens, Schoenfelder Priya, Edgar James R, Sansom David, Scudamore Cheryl L, Roychoudhuri Rahul, Garden Oliver A, Vanhaesebroeck Bart, Okkenhaug Klaus

Long-term treatment of cancer-prone germline PTEN mutant mice with low-dose rapamycin extends lifespan and delays tumour development

用低剂量雷帕霉素长期治疗易患癌症的生殖系PTEN突变小鼠,可延长其寿命并延缓肿瘤发展。

Tibarewal, Priyanka; Rathbone, Victoria; Constantinou, Georgia; Pearce, Wayne; Adil, Mahreen; Varyova, Zofia; Folkes, Lisa; Hampson, Alix; Classen, Gala Anastasia Electra; Alves, Adriana; Carvalho, Sara; Scudamore, Cheryl L; Vanhaesebroeck, Bart

Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?

为什么TRAF6敲入小鼠和TRAF6敲除小鼠的表型如此不同?

Petrova, Tsvetana; Bennett, Kyle; Nanda, Sambit; Strickson, Sam; Scudamore, Cheryl L; Prescott, Alan R; Cohen, Philip

The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities

在多个国际小鼠饲养设施中,C57BL/6N亚系雄性小鼠跗骨损伤的发生情况

Herbert, Eleanor; Stewart, Michelle; Hutchison, Marie; Flenniken, Ann M; Qu, Dawei; Nutter, Lauryl M J; McKerlie, Colin; Hobson, Liane; Kick, Brenda; Lyons, Bonnie; Wiegand, Jean-Paul; Doty, Rosalinda; Aguilar-Pimentel, Juan Antonio; Hrabe de Angelis, Martin; Dickinson, Mary; Seavitt, John; White, Jacqueline K; Scudamore, Cheryl L; Wells, Sara

Modification of an aggressive model of Alport Syndrome reveals early differences in disease pathogenesis due to genetic background

对一种侵袭性阿尔波特综合征模型的改良揭示了由于遗传背景导致的疾病发病机制早期差异

Falcone, Sara; Wisby, Laura; Nicol, Thomas; Blease, Andrew; Starbuck, Becky; Parker, Andrew; Sanderson, Jeremy; Brown, Steve D M; Scudamore, Cheryl L; Pusey, Charles D; Tam, Frederick W K; Potter, Paul K

Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues.

Dmp1启动子驱动的白喉毒素受体转基因表达在多种组织中产生意想不到的影响

Al-Jazzar Ahmed, Javaheri Behzad, Prideaux Matt, Boyde Alan, Scudamore Cheryl L, Cherifi Chahrazad, Hay Eric, Hopkinson Mark, Boyd Michael, Cohen-Solal Martine, Farquharson Colin, Pitsillides Andrew A

Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles

探索谷胱甘肽缺乏小鼠的瘦弱表型:硫醇、氨基酸和脂肪酸谱

Elshorbagy, Amany K; Jernerén, Fredrik; Scudamore, Cheryl L; McMurray, Fiona; Cater, Heather; Hough, Tertius; Cox, Roger; Refsum, Helga

Developing a Collaborative Agenda for Humanities and Social Scientific Research on Laboratory Animal Science and Welfare

制定人文和社会科学领域关于实验动物科学与福利研究的合作议程

Davies, Gail F; Greenhough, Beth J; Hobson-West, Pru; Kirk, Robert G W; Applebee, Ken; Bellingan, Laura C; Berdoy, Manuel; Buller, Henry; Cassaday, Helen J; Davies, Keith; Diefenbacher, Daniela; Druglitrø, Tone; Escobar, Maria Paula; Friese, Carrie; Herrmann, Kathrin; Hinterberger, Amy; Jarrett, Wendy J; Jayne, Kimberley; Johnson, Adam M; Johnson, Elizabeth R; Konold, Timm; Leach, Matthew C; Leonelli, Sabina; Lewis, David I; Lilley, Elliot J; Longridge, Emma R; McLeod, Carmen M; Miele, Mara; Nelson, Nicole C; Ormandy, Elisabeth H; Pallett, Helen; Poort, Lonneke; Pound, Pandora; Ramsden, Edmund; Roe, Emma; Scalway, Helen; Schrader, Astrid; Scotton, Chris J; Scudamore, Cheryl L; Smith, Jane A; Whitfield, Lucy; Wolfensohn, Sarah