日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations.

直接抑制 RAS 揭示了由 RAS G12 和 Q61 突变驱动的致癌信号的特征

Marasco Michelangelo, Kumar Dinesh, Garcia Borrego Santiago, Seale Tessa, Maddalena Giulia, Mezzadra Riccardo, Belanger Kylie, Cole Soren, Perez Brayan, Luan Wei, Mukherjee Radha, Aricescu Ilinca, Markov Vladimir, Zhu Yuxin, Arena Sabrina, Bardelli Alberto, de Stanchina Elisa, Lowe Scott W, Burkhart Richard A, Zimmerman Jacquelyn W, Yaeger Rona, Kopetz Scott E, Rosen Neal, Misale Sandra

Targeting rapid TKI-induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

靶向快速 TKI 诱导的 AXL 上调可克服适应性 ERK 再激活,并在 FLT3/ITD 急性髓系白血病中发挥抗白血病作用。

Seale, Tessa S; Li, Li; Bruner, J Kyle; Chou, Melody; Nguyen, Bao; Seo, Jaesung; Zhu, Ruiqi; Levis, Mark J; Pratilas, Christine A; Small, Donald