日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Systematic ocular phenotyping of 8,707 knockout mouse lines identifies genes associated with abnormal corneal phenotypes

对 8707 个基因敲除小鼠品系进行系统的眼部表型分析,鉴定出与异常角膜表型相关的基因。

Vo, Peter; Imai-Leonard, Denise M; Yang, Benjamin; Briere, Andrew; Shao, Andy; Casanova, M Isabel; Adams, David; Amano, Takanori; Amarie, Oana; Berberovic, Zorana; Bower, Lynette; Braun, Robert; Brown, Steve; Burrill, Samantha; Cho, Soo Young; Clementson-Mobbs, Sharon; D'Souza, Abigail; Dickinson, Mary; Eskandarian, Mohammad; Flenniken, Ann M; Fuchs, Helmut; Gailus-Durner, Valerie; Heaney, Jason; Hérault, Yann; Angelis, Martin Hrabe de; Hsu, Chih-Wei; Jin, Shundan; Joynson, Russell; Kang, Yeon Kyung; Kim, Haerim; Masuya, Hiroshi; Meziane, Hamid; Murray, Steve; Nam, Ki-Hoan; Noh, Hyuna; Nutter, Lauryl M J; Palkova, Marcela; Prochazka, Jan; Raishbrook, Miles Joseph; Riet, Fabrice; Ryan, Jennifer; Salazar, Jason; Seavey, Zachery; Seavitt, John Richard; Sedlacek, Radislav; Selloum, Mohammed; Seo, Kyoung Yul; Seong, Je Kyung; Shin, Hae-Sol; Shiroishi, Toshihiko; Stewart, Michelle; Svenson, Karen; Tamura, Masaru; Tolentino, Heather; Udensi, Uchechukwu; Wells, Sara; White, Jacqueline; Willett, Amelia; Wotton, Janine; Wurst, Wolfgang; Yoshiki, Atsushi; Lanoue, Louise; Lloyd, K C Kent; Leonard, Brian C; Roux, Michel J; McKerlie, Colin; Moshiri, Ala

Ocular Phenotyping of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes

基因敲除小鼠的眼部表型分析鉴定出与成年晚期视网膜表型相关的基因

Hang, Abraham; Shao, Andy; Shea, Michael; Roux, Michel J; Imai-Leonard, Denise M; Adams, David J; Amano, Takanori; Amarie, Oana V; Berberovic, Zorana; Bour, Raphaël; Bower, Lynette; Leonard, Brian C; Brown, Steve D; Cho, Soo Young; Clementson-Mobbs, Sharon; D'Souza, Abigail J; Dickinson, Mary; Eskandarian, Mohammad; Flenniken, Ann M; Fuchs, Helmut; Gailus-Durner, Valerie; Heaney, Jason; Hérault, Yann; Hrabe de Angelis, Martin; Hsu, Chih-Wei; Jin, Shundan; Joynson, Russell; Kang, Yeon Kyung; Kim, Haerim; Masuya, Hiroshi; Nam, Ki-Hoan; Noh, Hyuna; Nutter, Lauryl M J; Palkova, Marcela; Prochazka, Jan; Raishbrook, Miles Joseph; Riet, Fabrice; Salazar, Jason; Seavitt, John Richard; Sedlacek, Radislav; Selloum, Mohammed; Seo, Kyoung Yul; Seong, Je Kyung; Shin, Hae-Sol; Shiroishi, Toshihiko; Sorg, Tania; Stewart, Michelle; Tamura, Masaru; Tolentino, Heather; Udensi, Uchechukwu; Wells, Sara; Wurst, Wolfgang; Yoshiki, Atsushi; Meziane, Hamid; Yiu, Glenn; Sieving, Paul A; Lanoue, Louise; Lloyd, K C Kent; McKerlie, Colin; Moshiri, Ala

An oocyte-specific Cas9-expressing mouse for germline CRISPR/Cas9-mediated genome editing.

用于生殖系 CRISPR/Cas9 介导的基因组编辑的卵母细胞特异性 Cas9 表达小鼠

Lanza Denise G, Mao Jianqiang, Lorenzo Isabel, Liao Lan, Seavitt John R, Ljungberg M Cecilia, Simpson Elizabeth M, DeMayo Francesco J, Heaney Jason D

Whole genome analysis for 163 gRNAs in Cas9-edited mice reveals minimal off-target activity

对Cas9编辑小鼠中163个gRNA的全基因组分析显示,其脱靶活性极低。

Peterson, Kevin A; Khalouei, Sam; Hanafi, Nour; Wood, Joshua A; Lanza, Denise G; Lintott, Lauri G; Willis, Brandon J; Seavitt, John R; Braun, Robert E; Dickinson, Mary E; White, Jacqueline K; Lloyd, K C Kent; Heaney, Jason D; Murray, Stephen A; Ramani, Arun; Nutter, Lauryl M J

Delayed skeletal development and IGF-1 deficiency in a mouse model of lysinuric protein intolerance

赖氨酸尿蛋白不耐受小鼠模型中骨骼发育延迟和IGF-1缺乏

Bridget M Stroup ,Xiaohui Li ,Sara Ho ,Haonan Zhouyao ,Yuqing Chen ,Safa Ani ,Brian Dawson ,Zixue Jin ,Ronit Marom ,Ming-Ming Jiang ,Isabel Lorenzo ,Daniel Rosen ,Denise Lanza ,Nathalie Aceves ,Sara Koh ,John R Seavitt ,Jason D Heaney ,Brendan Lee ,Lindsay C Burrage

Untargeted Metabolomics of Slc13a5 Deficiency Reveal Critical Liver-Brain Axis for Lipid Homeostasis

非靶向代谢组学研究Slc13a5缺乏症揭示了肝脑轴在脂质稳态中的关键作用

Milosavljevic, Sofia; Glinton, Kevin E; Li, Xiqi; Medeiros, Cláudia; Gillespie, Patrick; Seavitt, John R; Graham, Brett H; Elsea, Sarah H

A resource of targeted mutant mouse lines for 5,061 genes

包含5061个基因的靶向突变小鼠品系资源

Birling, Marie-Christine; Yoshiki, Atsushi; Adams, David J; Ayabe, Shinya; Beaudet, Arthur L; Bottomley, Joanna; Bradley, Allan; Brown, Steve D M; Bürger, Antje; Bushell, Wendy; Chiani, Francesco; Chin, Hsian-Jean Genie; Christou, Skevoulla; Codner, Gemma F; DeMayo, Francesco J; Dickinson, Mary E; Doe, Brendan; Donahue, Leah Rae; Fray, Martin D; Gambadoro, Alessia; Gao, Xiang; Gertsenstein, Marina; Gomez-Segura, Alba; Goodwin, Leslie O; Heaney, Jason D; Hérault, Yann; de Angelis, Martin Hrabe; Jiang, Si-Tse; Justice, Monica J; Kasparek, Petr; King, Ruairidh E; Kühn, Ralf; Lee, Ho; Lee, Young Jae; Liu, Zhiwei; Lloyd, K C Kent; Lorenzo, Isabel; Mallon, Ann-Marie; McKerlie, Colin; Meehan, Terrence F; Fuentes, Violeta Munoz; Newman, Stuart; Nutter, Lauryl M J; Oh, Goo Taeg; Pavlovic, Guillaume; Ramirez-Solis, Ramiro; Rosen, Barry; Ryder, Edward J; Santos, Luis A; Schick, Joel; Seavitt, John R; Sedlacek, Radislav; Seisenberger, Claudia; Seong, Je Kyung; Skarnes, William C; Sorg, Tania; Steel, Karen P; Tamura, Masaru; Tocchini-Valentini, Glauco P; Wang, Chi-Kuang Leo; Wardle-Jones, Hannah; Wattenhofer-Donzé, Marie; Wells, Sara; Wiles, Michael V; Willis, Brandon J; Wood, Joshua A; Wurst, Wolfgang; Xu, Ying; Teboul, Lydia; Murray, Stephen A

Human and mouse essentiality screens as a resource for disease gene discovery

人类和小鼠必需基因筛选作为疾病基因发现的资源

Cacheiro, Pilar; Muñoz-Fuentes, Violeta; Murray, Stephen A; Dickinson, Mary E; Bucan, Maja; Nutter, Lauryl M J; Peterson, Kevin A; Haselimashhadi, Hamed; Flenniken, Ann M; Morgan, Hugh; Westerberg, Henrik; Konopka, Tomasz; Hsu, Chih-Wei; Christiansen, Audrey; Lanza, Denise G; Beaudet, Arthur L; Heaney, Jason D; Fuchs, Helmut; Gailus-Durner, Valerie; Sorg, Tania; Prochazka, Jan; Novosadova, Vendula; Lelliott, Christopher J; Wardle-Jones, Hannah; Wells, Sara; Teboul, Lydia; Cater, Heather; Stewart, Michelle; Hough, Tertius; Wurst, Wolfgang; Sedlacek, Radislav; Adams, David J; Seavitt, John R; Tocchini-Valentini, Glauco; Mammano, Fabio; Braun, Robert E; McKerlie, Colin; Herault, Yann; de Angelis, Martin Hrabě; Mallon, Ann-Marie; Lloyd, K C Kent; Brown, Steve D M; Parkinson, Helen; Meehan, Terrence F; Smedley, Damian

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density

大规模小鼠突变表型分析揭示了控制骨矿物质密度的新基因

Swan, Anna L; Schütt, Christine; Rozman, Jan; Del Mar Muñiz Moreno, Maria; Brandmaier, Stefan; Simon, Michelle; Leuchtenberger, Stefanie; Griffiths, Mark; Brommage, Robert; Keskivali-Bond, Piia; Grallert, Harald; Werner, Thomas; Teperino, Raffaele; Becker, Lore; Miller, Gregor; Moshiri, Ala; Seavitt, John R; Cissell, Derek D; Meehan, Terrence F; Acar, Elif F; Lelliott, Christopher J; Flenniken, Ann M; Champy, Marie-France; Sorg, Tania; Ayadi, Abdel; Braun, Robert E; Cater, Heather; Dickinson, Mary E; Flicek, Paul; Gallegos, Juan; Ghirardello, Elena J; Heaney, Jason D; Jacquot, Sylvie; Lally, Connor; Logan, John G; Teboul, Lydia; Mason, Jeremy; Spielmann, Nadine; McKerlie, Colin; Murray, Stephen A; Nutter, Lauryl M J; Odfalk, Kristian F; Parkinson, Helen; Prochazka, Jan; Reynolds, Corey L; Selloum, Mohammed; Spoutil, Frantisek; Svenson, Karen L; Vales, Taylor S; Wells, Sara E; White, Jacqueline K; Sedlacek, Radislav; Wurst, Wolfgang; Lloyd, K C Kent; Croucher, Peter I; Fuchs, Helmut; Williams, Graham R; Bassett, J H Duncan; Gailus-Durner, Valerie; Herault, Yann; Mallon, Ann-Marie; Brown, Steve D M; Mayer-Kuckuk, Philipp; Hrabe de Angelis, Martin

A global Slc7a7 knockout mouse model demonstrates characteristic phenotypes of human lysinuric protein intolerance

整体 Slc7a7 基因敲除小鼠模型表现出人类赖氨酸尿蛋白不耐受的特征表型

Bridget M Stroup, Ronit Marom, Xiaohui Li, Chih-Wei Hsu, Cheng-Yen Chang, Luan D Truong, Brian Dawson, Ingo Grafe, Yuqing Chen, Ming-Ming Jiang, Denise Lanza, Jennie Rose Green, Qin Sun, J P Barrish, Safa Ani, Audrey E Christiansen, John R Seavitt, Mary E Dickinson, Farrah Kheradmand, Jason D Heaney