日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury

PPARα在心脏适应缺氧中的关键作用以及饮食中的脂肪为何会加剧缺氧损伤

Cole, Mark A; Abd Jamil, Amira H; Heather, Lisa C; Murray, Andrew J; Sutton, Elizabeth R; Slingo, Mary; Sebag-Montefiore, Liam; Tan, Suat Cheng; Aksentijević, Dunja; Gildea, Ottilie S; Stuckey, Daniel J; Yeoh, Kar Kheng; Carr, Carolyn A; Evans, Rhys D; Aasum, Ellen; Schofield, Christopher J; Ratcliffe, Peter J; Neubauer, Stefan; Robbins, Peter A; Clarke, Kieran

Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity

丙二酰辅酶A脱羧酶(MCD)敲除小鼠因底物可塑性受限而出现心脏功能障碍和断奶期死亡率

Aksentijević, Dunja; McAndrew, Debra J; Karlstädt, Anja; Zervou, Sevasti; Sebag-Montefiore, Liam; Cross, Rebecca; Douglas, Gillian; Regitz-Zagrosek, Vera; Lopaschuk, Gary D; Neubauer, Stefan; Lygate, Craig A

Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice

缺乏肌酸:肌酸缺乏小鼠的运动能力和对慢性心肌梗死的反应未发生改变

Lygate, Craig A; Aksentijevic, Dunja; Dawson, Dana; ten Hove, Michiel; Phillips, Darci; de Bono, Joseph P; Medway, Debra J; Sebag-Montefiore, Liam; Hunyor, Imre; Channon, Keith M; Clarke, Kieran; Zervou, Sevasti; Watkins, Hugh; Balaban, Robert S; Neubauer, Stefan

Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.

通过靶向肌酸转运蛋白适度提高细胞内肌酸水平,可以保护小鼠免受急性心肌梗死的侵害

Lygate Craig A, Bohl Steffen, ten Hove Michiel, Faller Kiterie M E, Ostrowski Philip J, Zervou Sevasti, Medway Debra J, Aksentijevic Dunja, Sebag-Montefiore Liam, Wallis Julie, Clarke Kieran, Watkins Hugh, Schneider Jürgen E, Neubauer Stefan

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age

慢性肌酸激酶缺乏症最终会导致充血性心力衰竭,但其严重程度取决于遗传背景、性别和年龄。

Lygate, Craig A; Medway, Debra J; Ostrowski, Philip J; Aksentijevic, Dunja; Sebag-Montefiore, Liam; Hunyor, Imre; Zervou, Sevasti; Schneider, Jurgen E; Neubauer, Stefan

Changes in creatine transporter function during cardiac maturation in the rat

大鼠心脏成熟过程中肌酸转运蛋白功能的变化

Fischer, Alexandra; Ten Hove, Michiel; Sebag-Montefiore, Liam; Wagner, Helga; Clarke, Kieran; Watkins, Hugh; Lygate, Craig A; Neubauer, Stefan