日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combining BET inhibition with SMAC mimetics restricts tumor growth and triggers immune surveillance in preclinical cancer models

在临床前癌症模型中,BET抑制剂与SMAC模拟物联合使用可抑制肿瘤生长并触发免疫监视。

Ksenija Slavic Obradovic ,Florian Ebner ,Artem V Artemov ,Martina Miotto ,Paula-Elena Traexler ,Robin Jacob ,Ha Pham Thi Thanh ,Regina Ruzicka ,Andreas Wernitznig ,Ines Baumann ,Daniel Gerlach ,Maria-Antonietta Impagnatiello ,Salvatore Siena ,Mary Murphy ,Reniqua House ,Ulrich Reiser ,Valeria Santoro ,Johannes Popow ,Sebastian Carotta ,Anke Baum ,Jesse Lipp ,Alberto Bardelli ,Ulrike Tontsch-Grunt ,Mariangela Russo ,Martin Aichinger

Tumor microenvironment mimicking 3D models unveil the multifaceted effects of SMAC mimetics

模拟肿瘤微环境的3D模型揭示了SMAC模拟物的多方面作用

Catarina Pinto,Ksenija Slavic-Obradovic,Daniela Fürweger,Barbara Thaler,Abdallah Souabni,Sebastian Carotta,Martin Aichinger,Ulrich Reiser,Maria Antonietta Impagnatiello,Iñigo Tirapu

Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients

肺癌患者 PD1+ 肿瘤浸润淋巴细胞的功能和分子特征

Jesse J Lipp, Limei Wang, Haitang Yang, Feng Yao, Nathalie Harrer, Stefan Müller, Sabina Berezowska, Patrick Dorn, Thomas M Marti, Ralph A Schmid, Belazs Hegedüs, Abdallah Souabni, Sebastian Carotta, Mark A Pearson, Wolfgang Sommergruber, Greg J Kocher, Sean R R Hall

Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma

对抗 MAPK 靶向治疗的获得性耐药性赋予了黑色素瘤免疫逃避肿瘤微环境和对免疫治疗的交叉耐药性

Lisa Haas, Anais Elewaut, Camille L Gerard, Christian Umkehrer, Lukas Leiendecker, Malin Pedersen, Izabela Krecioch, David Hoffmann, Maria Novatchkova, Mario Kuttke, Tobias Neumann, Ines Pires da Silva, Harriet Witthock, Michel A Cuendet, Sebastian Carotta, Kevin J Harrington, Johannes Zuber, Richar

Cutibacterium acnes Infection Induces Type I Interferon Synthesis Through the cGAS-STING Pathway

痤疮杆菌感染通过 cGAS-STING 通路诱导 I 型干扰素合成

Katrin Fischer, Roland Tschismarov, Andreas Pilz, Susy Straubinger, Sebastian Carotta, Andrew McDowell, Thomas Decker

Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance

选择性强效 CDK8/19 抑制剂可增强 NK 细胞活性并促进肿瘤监视

Marco H Hofmann #, Rajeswaran Mani #, Harald Engelhardt #, Maria A Impagnatiello, Sebastian Carotta, Marc Kerenyi, Seila Lorenzo-Herrero, Jark Böttcher, Dirk Scharn, Heribert Arnhof, Andreas Zoephel, Renate Schnitzer, Thomas Gerstberger, Michael P Sanderson, Girish Rajgolikar, Swagata Goswami, Sumit

HOXB4 Promotes Hemogenic Endothelium Formation without Perturbing Endothelial Cell Development

HOXB4 促进造血内皮细胞形成而不干扰内皮细胞发育

Nadine Teichweyde, Lara Kasperidus, Sebastian Carotta, Valerie Kouskoff, Georges Lacaud, Peter A Horn, Stefan Heinrichs, Hannes Klump

PU.1 Is Required for the Developmental Progression of Multipotent Progenitors to Common Lymphoid Progenitors

PU.1 是多能祖细胞向常见淋巴祖细胞发育进程所必需的

Swee Heng Milon Pang, Carolyn A de Graaf, Douglas J Hilton, Nicholas D Huntington, Sebastian Carotta, Li Wu, Stephen L Nutt

Complementarity and redundancy of IL-22-producing innate lymphoid cells

产生 IL-22 的先天淋巴细胞的互补性和冗余性

Lucille C Rankin, Mathilde J H Girard-Madoux, Cyril Seillet, Lisa A Mielke, Yann Kerdiles, Aurore Fenis, Elisabeth Wieduwild, Tracy Putoczki, Stanislas Mondot, Olivier Lantz, Dieter Demon, Anthony T Papenfuss, Gordon K Smyth, Mohamed Lamkanfi, Sebastian Carotta, Jean-Christophe Renauld, Wei Shi, Sab

Novel non-canonical role of STAT1 in Natural Killer cell cytotoxicity

STAT1 在自然杀伤细胞毒性中的新非典型作用

Eva Maria Putz, Andrea Majoros, Dagmar Gotthardt, Michaela Prchal-Murphy, Eva Maria Zebedin-Brandl, Daniela Alexandra Fux, Andreas Schlattl, Robert D Schreiber, Sebastian Carotta, Mathias Müller, Christopher Gerner, Thomas Decker, Veronika Sexl