MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage
MAT2A 抑制通过减少 PRMT5 依赖性 mRNA 剪接和诱导 DNA 损伤来阻止 MTAP 删除的癌细胞的生长
期刊:Cancer Cell
影响因子:48.8
doi:10.1016/j.ccell.2020.12.010
Peter Kalev, Marc L Hyer, Stefan Gross, Zenon Konteatis, Chi-Chao Chen, Mark Fletcher, Max Lein, Elia Aguado-Fraile, Victoria Frank, Amelia Barnett, Everton Mandley, Joshua Goldford, Yue Chen, Katie Sellers, Sebastian Hayes, Kate Lizotte, Phong Quang, Yesim Tuncay, Michelle Clasquin, Rachel Peters,