日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease.

PLA2G15 是一种 BMP 水解酶,靶向 PLA2G15 可改善溶酶体疾病

Nyame Kwamina, Xiong Jian, Alsohybe Hisham N, de Jong Arthur P H, Peña Isabelle V, de Miguel Ricardo, Brummelkamp Thijn R, Hartmann Guido, Nijman Sebastian M B, Raaben Matthijs, Simcox Judith A, Blomen Vincent A, Abu-Remaileh Monther

PLA2G15 is a Lysosomal BMP Hydrolase and its Targeting Ameliorates Lysosomal Disease

PLA2G15 是一种溶酶体 BMP 水解酶,靶向 PLA2G15 可改善溶酶体疾病。

Nyame, Kwamina; Xiong, Jian; Alsohybe, Hisham N; de Jong, Arthur Ph; Peña, Isabelle V; de Miguel, Ricardo; Brummelkamp, Thijn R; Hartmann, Guido; Nijman, Sebastian M B; Raaben, Matthijs; Simcox, Judith A; Blomen, Vincent A; Abu-Remaileh, Monther

Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7

发现一种对组蛋白赖氨酸去甲基化酶 KDM2/7 具有高选择性的细胞活性抑制剂

Gerken, Philip A; Wolstenhulme, Jamie R; Tumber, Anthony; Hatch, Stephanie B; Zhang, Yijia; Müller, Susanne; Chandler, Shane A; Mair, Barbara; Li, Fengling; Nijman, Sebastian M B; Konietzny, Rebecca; Szommer, Tamas; Yapp, Clarence; Fedorov, Oleg; Benesch, Justin L P; Vedadi, Masoud; Kessler, Benedikt M; Kawamura, Akane; Brennan, Paul E; Smith, Martin D

MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated

MEK 抑制剂可阻断毛细血管扩张性共济失调症突变的肺癌生长

Michal Smida, Ferran Fece de la Cruz, Claudia Kerzendorfer, Iris Z Uras, Barbara Mair, Abdelghani Mazouzi, Tereza Suchankova, Tomasz Konopka, Amanda M Katz, Keren Paz, Katalin Nagy-Bojarszky, Markus K Muellner, Zsuzsanna Bago-Horvath, Eric B Haura, Joanna I Loizou, Sebastian M B Nijman

Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity

乳腺癌基因 GATA3 的功能获得性突变和功能丧失性突变导致药物敏感性差异

Barbara Mair, Tomasz Konopka, Claudia Kerzendorfer, Katia Sleiman, Sejla Salic, Violeta Serra, Markus K Muellner, Vasiliki Theodorou, Sebastian M B Nijman

A generic strategy for CRISPR-Cas9-mediated gene tagging

一种通用的CRISPR-Cas9介导的基因标记策略

Lackner, Daniel H; Carré, Alexia; Guzzardo, Paloma M; Banning, Carina; Mangena, Ramu; Henley, Tom; Oberndorfer, Sarah; Gapp, Bianca V; Nijman, Sebastian M B; Brummelkamp, Thijn R; Bürckstümmer, Tilmann

A thesaurus of genetic variation for interrogation of repetitive genomic regions

用于研究重复基因组区域的遗传变异词库

Kerzendorfer, Claudia; Konopka, Tomasz; Nijman, Sebastian M B

Light-assisted small-molecule screening against protein kinases

光辅助筛选蛋白激酶小分子

Álvaro Inglés-Prieto, Eva Reichhart, Markus K Muellner, Matthias Nowak, Sebastian M B Nijman, Michael Grusch, Harald Janovjak

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

利用 CRISPR/Cas9 进行兆碱基级基因敲除,生成完全单倍体人类细胞系

Essletzbichler, Patrick; Konopka, Tomasz; Santoro, Federica; Chen, Doris; Gapp, Bianca V; Kralovics, Robert; Brummelkamp, Thijn R; Nijman, Sebastian M B; Bürckstümmer, Tilmann

TOPS: a versatile software tool for statistical analysis and visualization of combinatorial gene-gene and gene-drug interaction screens

TOPS:一款功能全面的软件工具,用于对基因-基因和基因-药物相互作用筛选进行统计分析和可视化。

Muellner, Markus K; Duernberger, Gerhard; Ganglberger, Florian; Kerzendorfer, Claudia; Uras, Iris Z; Schoenegger, Andreas; Bagienski, Klaudia; Colinge, Jacques; Nijman, Sebastian M B