日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Type II kinase inhibitors that target Parkinson's disease-associated LRRK2

靶向帕金森病相关LRRK2的II型激酶抑制剂

Nicolai D Raig ,Katherine J Surridge ,Marta Sanz-Murillo ,Verena Dederer ,Andreas Krämer ,Martin P Schwalm ,Nicholas M Lattal ,Lewis Elson ,Deep Chatterjee ,Sebastian Mathea ,Thomas Hanke ,Andres E Leschziner ,Samara L Reck-Peterson ,Stefan Knapp

Covalent Targeting Leads to the Development of a LIMK1 Isoform-Selective Inhibitor

共价靶向导致LIMK1亚型选择性抑制剂的开发

Sebastian Mandel ,Thomas Hanke ,Niall Prendiville ,María Baena-Nuevo ,Lena Marie Berger ,Frederic Farges ,Martin Peter Schwalm ,Benedict-Tilman Berger ,Andreas Kraemer ,Lewis Elson ,Hayuningbudi Saraswati ,Kamal R Abdul Azeez ,Verena Dederer ,Sebastian Mathea ,Ana Corrionero ,Patricia Alfonso ,Sabrina Keller ,Matthias Gstaiger ,Daniela S Krause ,Susanne Müller ,Sandra Röhm ,Stefan Knapp

Type-II kinase inhibitors that target Parkinson's Disease-associated LRRK2

针对帕金森病相关 LRRK2 的 II 型激酶抑制剂

Nicolai D Raig, Katherine J Surridge, Marta Sanz-Murillo, Verena Dederer, Andreas Krämer, Martin P Schwalm, Lewis Elson, Deep Chatterjee, Sebastian Mathea, Thomas Hanke, Andres E Leschziner, Samara L Reck-Peterson, Stefan Knapp

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

重组系统中人类 PINK1 在 TOM 复合体上的激活机制

Olawale G Raimi, Hina Ojha, Kenneth Ehses, Verena Dederer, Sven M Lange, Cristian Polo Rivera, Tom D Deegan, Yinchen Chen, Melanie Wightman, Rachel Toth, Karim P M Labib, Sebastian Mathea, Neil Ranson, Rubén Fernández-Busnadiego, Miratul M K Muqit

A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2

一种设计的锚蛋白重复蛋白,靶向帕金森病相关的 LRRK2

Verena Dederer, Marta Sanz Murillo, Eva P Karasmanis, Kathryn S Hatch, Deep Chatterjee, Franziska Preuss, Kamal R Abdul Azeez, Landon Vu Nguyen, Christian Galicia, Birgit Dreier, Andreas Plückthun, Wim Versees, Sebastian Mathea, Andres E Leschziner, Samara L Reck-Peterson, Stefan Knapp

Structure of LRRK1 and mechanisms of autoinhibition and activation

LRRK1 的结构以及自身抑制和激活机制

Janice M Reimer, Andrea M Dickey #, Yu Xuan Lin #, Robert G Abrisch #, Sebastian Mathea, Deep Chatterjee, Elizabeth J Fay, Stefan Knapp, Matthew D Daugherty, Samara L Reck-Peterson, Andres E Leschziner

Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures

型和 II 型激酶抑制剂对帕金森病相关 LRRK2 的抑制:活性和结构

Marta Sanz Murillo, Amalia Villagran Suarez, Verena Dederer, Deep Chatterjee, Jaime Alegrio Louro, Stefan Knapp, Sebastian Mathea, Andres E Leschziner

Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA

吡咯烷二酮作为细菌酶 MurA 新型抑制剂的鉴定和生化特性

Reem K Fathalla, Wolfgang Fröhner, Chantal D Bader, Patrick D Fischer, Charlotte Dahlem, Deep Chatterjee, Sebastian Mathea, Alexandra K Kiemer, Haribabu Arthanari, Rolf Müller, Mohammad Abdel-Halim, Christian Ducho, Matthias Engel

Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes

型、II 型和 III 型 LIM-激酶化学探针的开发和表征

Thomas Hanke, Sebastian Mathea, Julia Woortman, Eidarus Salah, Benedict-Tilman Berger, Anthony Tumber, Risa Kashima, Akiko Hata, Bernhard Kuster, Susanne Müller, Stefan Knapp

A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins

用于生成杆状病毒 IAP 重复蛋白化学探针的工具箱

Martin P Schwalm, Lena M Berger, Maximilian N Meuter, James D Vasta, Cesear R Corona, Sandra Röhm, Benedict-Tilman Berger, Frederic Farges, Sebastian M Beinert, Franziska Preuss, Viktoria Morasch, Vladimir V Rogov, Sebastian Mathea, Krishna Saxena, Matthew B Robers, Susanne Müller, Stefan Knapp