日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor

上皮剪接调节剂 ESRP2 在 Wilms 肿瘤中受到 DNA 高甲基化的表观遗传抑制,并充当肿瘤抑制因子

Danny Legge, Ling Li, Whei Moriarty, David Lee, Marianna Szemes, Asef Zahed, Leonidas Panousopoulos, Wan Yun Chung, Yara Aghabi, Jasmin Barratt, Richard Williams, Kathy Pritchard-Jones, Karim T A Malik, Sebastian Oltean, Keith W Brown

A drug-repositioning screen using splicing-sensitive fluorescent reporters identifies novel modulators of VEGF-A splicing with anti-angiogenic properties

使用剪接敏感荧光报告基因的药物重新定位筛选可识别具有抗血管生成特性的 VEGF-A 剪接的新型调节剂

Eleanor Star #, Megan Stevens #, Clare Gooding, Christopher W J Smith, Ling Li, Monica Lamici Ayine, Steve J Harper, David O Bates, Sebastian Oltean

CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer

CDC2 样 (CLK) 蛋白激酶抑制作为前列腺癌的新型靶向治疗策略

Simon Uzor, Sean R Porazinski, Ling Li, Bethany Clark, Masahiko Ajiro, Kei Iida, Masatoshi Hagiwara, Abdullah A Alqasem, Claire M Perks, Ian D Wilson, Sebastian Oltean, Michael R Ladomery

Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer

利用剪接转换寡核苷酸靶向 ERG 致癌基因作为前列腺癌的新治疗策略

Ling Li, Lisa Hobson, Laura Perry, Bethany Clark, Susan Heavey, Aiman Haider, Ashwin Sridhar, Greg Shaw, John Kelly, Alex Freeman, Ian Wilson, Hayley Whitaker, Elmar Nurmemmedov, Sebastian Oltean, Sean Porazinski #, Michael Ladomery #

The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties

进化上保守的盒式外显子 7b 驱动 ERG 的致癌特性

Samantha L Jumbe, Sean R Porazinski, Sebastian Oltean, Jason P Mansell, Bahareh Vahabi, Ian D Wilson, Michael R Ladomery

Vascular Endothelial Growth Factor-A165b Restores Normal Glomerular Water Permeability in a Diphtheria-Toxin Mouse Model of Glomerular Injury

血管内皮生长因子-A165b 在白喉毒素小鼠肾小球损伤模型中恢复正常肾小球水通透性

Megan Stevens, Christopher R Neal, Andrew H J Salmon, David O Bates, Steven J Harper, Sebastian Oltean

The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis

小分子抑制剂 YK-4-279 可破坏神经母细胞瘤细胞的有丝分裂进程,克服耐药性并与有丝分裂抑制剂产生协同作用

Madhu Kollareddy, Alice Sherrard, Ji Hyun Park, Marianna Szemes, Kelli Gallacher, Zsombor Melegh, Sebastian Oltean, Martin Michaelis, Jindrich Cinatl Jr, Abderrahmane Kaidi, Karim Malik

VEGF-A165 b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney

VEGF-A165 b 可在小鼠模型中预防蛋白尿,该模型会随着肾脏中所有内源性 VEGF-A 剪接异构体的逐渐耗尽而发生

Megan Stevens, Christopher R Neal, Andrew H J Salmon, David O Bates, Steven J Harper, Sebastian Oltean

Serine-arginine protein kinase 1 (SRPK1), a determinant of angiogenesis, is upregulated in prostate cancer and correlates with disease stage and invasion

丝氨酸-精氨酸蛋白激酶 1 (SRPK1) 是血管生成的决定因素,在前列腺癌中上调,并与疾病分期和侵袭相关

Nicholas Bullock, Jonathan Potts, Andrew J Simpkin, Anthony Koupparis, Steve J Harper, Jon Oxley, Sebastian Oltean

Vascular Endothelial Growth Factor-A165b Is Protective and Restores Endothelial Glycocalyx in Diabetic Nephropathy

血管内皮生长因子-A165b 具有保护作用并可恢复糖尿病肾病中的内皮糖萼

Sebastian Oltean, Yan Qiu, Joanne K Ferguson, Megan Stevens, Chris Neal, Amy Russell, Amit Kaura, Kenton P Arkill, Kirstie Harris, Clare Symonds, Katja Lacey, Lihini Wijeyaratne, Melissa Gammons, Emma Wylie, Richard P Hulse, Chloe Alsop, George Cope, Gopinath Damodaran, Kai B Betteridge, Raina Ramna