日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

In vivo evolution of env in SHIV-AD8EO-infected rhesus macaques after AAV-vectored delivery of eCD4-Ig

在 AAV 载体递送 eCD4-Ig 后 SHIV-AD8EO 感染恒河猴体内 env 的进化

Daniel O'Hagan, Siddhartha Shandilya, Lincoln J Hopkins, Patricia A Hahn, Sebastian P Fuchs, José M Martinez-Navio, Michael D Alpert, Mathew R Gardner, Ronald C Desrosiers, Guangping Gao, Jeffrey D Lifson, Michael Farzan, Amir Ardeshir, Mauricio A Martins1

The Immunogenicity of AAV-Encoded HIV-1 bNAbs in Rhesus Macaques Is Unaffected by a Short Course of the Immunomodulator CTLA4Ig

在恒河猴中,AAV编码的HIV-1广谱中和抗体的免疫原性不受短期免疫调节剂CTLA4Ig治疗的影响。

Patricia A Hahn ,Siddhartha Shandilya ,Lucas A B da Costa ,Laura C F da Silva ,Daniel O'Hagan ,Brian Liang ,Kathleen Engelman ,Matthew R Gardner ,Guangping Gao ,Sebastian P Fuchs ,Jose M Martinez-Navio ,Ronald C Desrosiers ,Amir Ardeshir ,Diogo M Magnani ,Mauricio A Martins

Long-Term Delivery of an Anti-SIV Monoclonal Antibody With AAV

利用腺相关病毒载体(AAV)长期递送抗SIV单克隆抗体。

José M Martinez-Navio ,Sebastian P Fuchs ,Desiree E Mendes ,Eva G Rakasz ,Guangping Gao ,Jeffrey D Lifson ,Ronald C Desrosiers

Adeno-Associated Virus Delivery of Anti-HIV Monoclonal Antibodies Can Drive Long-Term Virologic Suppression

腺相关病毒递送抗 HIV 单克隆抗体可实现长期病毒学抑制

José M Martinez-Navio, Sebastian P Fuchs, Shara N Pantry, William A Lauer, Natasha N Duggan, Brandon F Keele, Eva G Rakasz, Guangping Gao, Jeffrey D Lifson, Ronald C Desrosiers

Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity

通过 miR142 介导的调控绕过细胞免疫,足以支持 rAAV 递送的 OVA 表达,而无需激活体液免疫。

Yuanyuan Xiao ,Manish Muhuri ,Shaoyong Li ,Wanru Qin ,Guangchao Xu ,Li Luo ,Jia Li ,Alexander J Letizia ,Sean K Wang ,Ying Kai Chan ,Chunmei Wang ,Sebastian P Fuchs ,Dan Wang ,Qin Su ,M Abu Nahid ,George M Church ,Michael Farzan ,Li Yang ,Yuquan Wei ,Ronald C Desrosiers ,Christian Mueller ,Phillip Wl Tai ,Guangping Gao

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

AAV 表达的 eCD4-Ig 可提供针对多种 SHIV 攻击的持久保护

Matthew R Gardner, Lisa M Kattenhorn, Hema R Kondur, Markus von Schaewen, Tatyana Dorfman, Jessica J Chiang, Kevin G Haworth, Julie M Decker, Michael D Alpert, Charles C Bailey, Ernest S Neale Jr, Christoph H Fellinger, Vinita R Joshi, Sebastian P Fuchs, Jose M Martinez-Navio, Brian D Quinlan, Annie