日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inflammatory Non-CpG Antisense Oligonucleotides Are Signaling Through TLR9 in Human Burkitt Lymphoma B Bjab Cells

炎症性非 CpG 反义寡核苷酸通过人类伯基特淋巴瘤 B Bjab 细胞中的 TLR9 发出信号

Adam J Pollak, Patrick Cauntay, Todd Machemer, Suzanne Paz, Sagar Damle, Scott P Henry, Sebastien A Burel

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides

迈向下一代反义寡核苷酸:甲磺酰基磷酰胺修饰可改善间隙体反义寡核苷酸的治疗指数和作用持续时间

Brooke A Anderson, Graeme C Freestone, Audrey Low, Cheryl L De-Hoyos, William J Drury Iii, Michael E Østergaard, Michael T Migawa, Michael Fazio, W Brad Wan, Andres Berdeja, Eli Scandalis, Sebastien A Burel, Timothy A Vickers, Stanley T Crooke, Eric E Swayze, Xuehai Liang, Punit P Seth

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts

高亲和力 gapmer 反义寡核苷酸的肝毒性是由 RNase H1 依赖的极长前 mRNA 转录本的混杂还原介导的

Sebastien A Burel, Christopher E Hart, Patrick Cauntay, Jill Hsiao, Todd Machemer, Melanie Katz, Andy Watt, Huynh-Hoa Bui, Husam Younis, Mahyar Sabripour, Susan M Freier, Gene Hung, Amy Dan, T P Prakash, Punit P Seth, Eric E Swayze, C Frank Bennett, Stanley T Crooke, Scott P Henry

Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys

针对信号转导和转录激活因子3的新型限制性乙基修饰反义化合物在小鼠和食蟹猴中的毒理作用的临床前评估

Sebastien A Burel, So-Ri Han, Hong-Soo Lee, Daniel A Norris, Byoung-Seok Lee, Todd Machemer, Shin-Young Park, Tianyuan Zhou, Guobin He, Youngsoo Kim, A Robert MacLeod, Brett P Monia, Shirley Lio, Tae-Won Kim, Scott P Henry