日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pharmacokinetic-pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies

在临床前和临床研究中,药代动力学-药效学指导优化 HDM2 抑制剂 CGM097 的剂量和用药方案

Sebastian Bauer, George D Demetri, Ensar Halilovic, Reinhard Dummer, Christophe Meille, Daniel S W Tan, Nelson Guerreiro, Astrid Jullion, Stephane Ferretti, Sebastien Jeay, Laurence Van Bree, Florence Hourcade-Potelleret, Jens U Wuerthner, Claire Fabre, Philippe A Cassier

Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models

ALK 和 MDM2 联合抑制可增强抗肿瘤活性并克服人类 ALK 突变神经母细胞瘤细胞系和异种移植模型中的耐药性

Hui Qin Wang, Ensar Halilovic, Xiaoyan Li, Jinsheng Liang, Yichen Cao, Daniel P Rakiec, David A Ruddy, Sebastien Jeay, Jens U Wuerthner, Noelito Timple, Shailaja Kasibhatla, Nanxin Li, Juliet A Williams, William R Sellers, Alan Huang, Fang Li

Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/- mouse model

通过 Arf-/- 小鼠模型中的体内 piggyBac 转座子诱变筛选确定对 TP53-MDM2 抑制的抗性机制

Emilie A Chapeau, Agnieszka Gembarska, Eric Y Durand, Emeline Mandon, Claire Estadieu, Vincent Romanet, Marion Wiesmann, Ralph Tiedt, Joseph Lehar, Antoine de Weck, Roland Rad, Louise Barys, Sebastien Jeay, Stephane Ferretti, Audrey Kauffmann, Esther Sutter, Armelle Grevot, Pierre Moulin, Masato Mur

Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097

新型小分子 HDM2 抑制剂 CGM097 抑制野生型 p53 表达 AML

Ellen Weisberg, Ensar Halilovic, Vesselina G Cooke, Atsushi Nonami, Tao Ren, Takaomi Sanda, Irene Simkin, Jing Yuan, Brandon Antonakos, Louise Barys, Moriko Ito, Richard Stone, Ilene Galinsky, Kristen Cowens, Erik Nelson, Martin Sattler, Sebastien Jeay, Jens U Wuerthner, Sean M McDonough, Marion Wie

Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition

在可通过特异性受体抑制靶向的原位异种移植模型中,Wilms 肿瘤细胞对胰岛素样生长因子 1 信号传导的依赖性

Aleksandra Bielen, Gary Box, Lara Perryman, Lynn Bjerke, Sergey Popov, Yann Jamin, Alexa Jury, Melanie Valenti, Alexis de Haven Brandon, Vanessa Martins, Vincent Romanet, Sebastien Jeay, Florence I Raynaud, Francesco Hofmann, Simon P Robinson, Suzanne A Eccles, Chris Jones