日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Quantitative High-Throughput Screen Identifies Compounds that Upregulate the p53 Isoform Δ133p53α and Inhibit Cellular Senescence.

定量高通量筛选鉴定出能上调 p53 同工型 Δ133p53α 并抑制细胞衰老的化合物

Lissa Delphine, Joruiz Sebastien M, Dranchak Patricia K, Ungerleider Kyra, Yamada Leo, Horikawa Izumi, Oliphant Erin, Manubag Rebecca, Von Muhlinen Natalia, Beck Jessica, Harris Brent T, Inglese James, Harris Curtis

Pharmacologic activation of Δ133p53α reduces cellular senescence in progeria patients-derived cells

药物激活Δ133p53α可减少早衰症患者来源细胞的衰老

Joruiz, Sebastien M; Lissa, Delphine; Von Muhlinen, Natalia; Dranchak, Patricia K; Inglese, James; Horikawa, Izumi; Harris, Curtis C

Germline variant affecting p53β isoforms predisposes to familial cancer

影响 p53β 亚型的生殖细胞变异会导致家族性癌症

Stephanie A Schubert, Dina Ruano, Sebastien M Joruiz, Jordy Stroosma, Nikolina Glavak, Anna Montali, Lia M Pinto, Mar Rodríguez-Girondo, Daniela Q C M Barge-Schaapveld, Maartje Nielsen, Bernadette P M van Nesselrooij, Arjen R Mensenkamp, Monique E van Leerdam, Thomas H Sharp, Hans Morreau, Jean-Chri

Lineage-specific splicing regulation of MAPT gene in the primate brain

灵长类动物大脑中 MAPT 基因的谱系特异性剪接调控

Yocelyn Recinos, Suying Bao, Xiaojian Wang, Brittany L Phillips, Yow-Tyng Yeh, Sebastien M Weyn-Vanhentenryck, Maurice S Swanson, Chaolin Zhang

Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence

野生型和R273H突变型Δ133p53α的不同功能差异性地调节胶质母细胞瘤的侵袭性和治疗诱导的衰老

Joruiz, Sebastien M; Von Muhlinen, Natalia; Horikawa, Izumi; Gilbert, Mark R; Harris, Curtis C

The complex lipid, SPPCT-800, reduces lung damage, improves pulmonary function and decreases pro-inflammatory cytokines in the murine LPS-induced acute respiratory distress syndrome (ARDS) model

复合脂质SPPCT-800可减轻小鼠LPS诱导的急性呼吸窘迫综合征(ARDS)模型中的肺损伤,改善肺功能并降低促炎细胞因子水平。

Sordillo, Peter P; Allaire, Andrea; Bouchard, Annie; Salvail, Dan; Labbe, Sebastien M

The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer

Δ133p53β亚型促进免疫抑制环境,从而导致侵袭性前列腺癌。

Kazantseva, Marina; Mehta, Sunali; Eiholzer, Ramona A; Gimenez, Gregory; Bowie, Sara; Campbell, Hamish; Reily-Bell, Ashley L; Roth, Imogen; Ray, Sankalita; Drummond, Catherine J; Reid, Glen; Joruiz, Sebastien M; Wiles, Anna; Morrin, Helen R; Reader, Karen L; Hung, Noelyn A; Baird, Margaret A; Slatter, Tania L; Braithwaite, Antony W

Precise temporal regulation of alternative splicing during neural development

神经发育过程中选择性剪接的精确时间调控

Sebastien M Weyn-Vanhentenryck ,Huijuan Feng ,Dmytro Ustianenko ,Rachel Duffié ,Qinghong Yan ,Martin Jacko ,Jose C Martinez ,Marianne Goodwin ,Xuegong Zhang ,Ulrich Hengst ,Stavros Lomvardas ,Maurice S Swanson ,Chaolin Zhang

Rbfox Splicing Factors Promote Neuronal Maturation and Axon Initial Segment Assembly

Rbfox剪接因子促进神经元成熟和轴突起始段组装

Martin Jacko ,Sebastien M Weyn-Vanhentenryck ,John W Smerdon ,Rui Yan ,Huijuan Feng ,Damian J Williams ,Joy Pai ,Ke Xu ,Hynek Wichterle ,Chaolin Zhang

LIN28 Selectively Modulates a Subclass of Let-7 MicroRNAs

LIN28 选择性地调节 Let-7 微 RNA 的一个子类

Dmytro Ustianenko, Hua-Sheng Chiu, Thomas Treiber, Sebastien M Weyn-Vanhentenryck, Nora Treiber, Gunter Meister, Pavel Sumazin, Chaolin Zhang