日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

AAV-mediated neuronal expression of an scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models

在阿尔茨海默病模型中,AAV介导的神经元表达选择性针对Aβ寡聚体的scFv抗体可保护突触并挽救记忆。

Selles, Maria Clara; Fortuna, Juliana T S; Cercato, Magali C; Santos, Luis Eduardo; Domett, Luciana; Bitencourt, Andre L B; Carraro, Mariane Favero; Souza, Amanda S; Janickova, Helena; Azevedo, Caroline Vieira; Campos, Henrique Correia; de Souza, Jorge M; Alves-Leon, Soniza; Prado, Vania F; Prado, Marco A M; Epstein, Alberto L; Salvetti, Anna; Longo, Beatriz Monteiro; Arancio, Ottavio; Klein, William L; Sebollela, Adriano; De Felice, Fernanda G; Jerusalinsky, Diana A; Ferreira, Sergio T

Morphological, cellular, and molecular basis of brain infection in COVID-19 patients

新冠肺炎患者脑部感染的形态学、细胞学和分子学基础

Crunfli, Fernanda; Carregari, Victor C; Veras, Flavio P; Silva, Lucas S; Nogueira, Mateus Henrique; Antunes, André Saraiva Leão Marcelo; Vendramini, Pedro Henrique; Valença, Aline Gazzola Fragnani; Brandão-Teles, Caroline; Zuccoli, Giuliana da Silva; Reis-de-Oliveira, Guilherme; Silva-Costa, Lícia C; Saia-Cereda, Verônica Monteiro; Smith, Bradley J; Codo, Ana Campos; de Souza, Gabriela F; Muraro, Stéfanie P; Parise, Pierina Lorencini; Toledo-Teixeira, Daniel A; Santos de Castro, Ícaro Maia; Melo, Bruno Marcel; Almeida, Glaucia M; Firmino, Egidi Mayara Silva; Paiva, Isadora Marques; Silva, Bruna Manuella Souza; Guimarães, Rafaela Mano; Mendes, Niele D; Ludwig, Raíssa L; Ruiz, Gabriel P; Knittel, Thiago L; Davanzo, Gustavo G; Gerhardt, Jaqueline Aline; Rodrigues, Patrícia Brito; Forato, Julia; Amorim, Mariene Ribeiro; Brunetti, Natália S; Martini, Matheus Cavalheiro; Benatti, Maíra Nilson; Batah, Sabrina S; Siyuan, Li; João, Rafael B; Aventurato, Ítalo K; Rabelo de Brito, Mariana; Mendes, Maria J; da Costa, Beatriz A; Alvim, Marina K M; da Silva Júnior, José Roberto; Damião, Lívia L; de Sousa, Iêda Maria P; da Rocha, Elessandra D; Gonçalves, Solange M; Lopes da Silva, Luiz H; Bettini, Vanessa; Campos, Brunno M; Ludwig, Guilherme; Tavares, Lucas Alves; Pontelli, Marjorie Cornejo; Viana, Rosa Maria Mendes; Martins, Ronaldo B; Vieira, Andre Schwambach; Alves-Filho, José Carlos; Arruda, Eurico; Podolsky-Gondim, Guilherme Gozzoli; Santos, Marcelo Volpon; Neder, Luciano; Damasio, André; Rehen, Stevens; Vinolo, Marco Aurélio Ramirez; Munhoz, Carolina Demarchi; Louzada-Junior, Paulo; Oliveira, Renê Donizeti; Cunha, Fernando Q; Nakaya, Helder I; Mauad, Thais; Duarte-Neto, Amaro Nunes; Ferraz da Silva, Luiz Fernando; Dolhnikoff, Marisa; Saldiva, Paulo Hilario Nascimento; Farias, Alessandro S; Cendes, Fernando; Moraes-Vieira, Pedro Manoel M; Fabro, Alexandre T; Sebollela, Adriano; Proença-Modena, José L; Yasuda, Clarissa L; Mori, Marcelo A; Cunha, Thiago M; Martins-de-Souza, Daniel

SARS-CoV-2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytes

SARS-CoV-2感染会影响碳代谢,并且在叙利亚仓鼠星形胶质细胞中复制依赖于谷氨酰胺。

de Oliveira, Lilian Gomes; de Souza Angelo, Yan; Yamamoto, Pedro; Carregari, Victor Corasolla; Crunfli, Fernanda; Reis-de-Oliveira, Guilherme; Costa, Lícia; Vendramini, Pedro Henrique; Duque, Érica Almeida; Dos Santos, Nilton Barreto; Firmino, Egidi Mayara; Paiva, Isadora Marques; Almeida, Glaucia Maria; Sebollela, Adriano; Polonio, Carolina Manganeli; Zanluqui, Nagela Ghabdan; de Oliveira, Marília Garcia; da Silva, Patrick; Davanzo, Gustavo Gastão; Ayupe, Marina Caçador; Salgado, Caio Loureiro; de Souza Filho, Antônio Francisco; de Araújo, Marcelo Valdemir; Silva-Pereira, Taiana Tainá; de Almeida Campos, Angélica Cristine; Góes, Luiz Gustavo Bentim; Dos Passos Cunha, Marielton; Caldini, Elia Garcia; D'Império Lima, Maria Regina; Fonseca, Denise Morais; de Sá Guimarães, Ana Márcia; Minoprio, Paola Camargo; Munhoz, Carolina Demarchi; Mori, Cláudia Madalena Cabrera; Moraes-Vieira, Pedro Manoel; Cunha, Thiago Mattar; Martins-de-Souza, Daniel; Peron, Jean Pierre Schatzmann

Modeling the Human Brain With ex vivo Slices and in vitro Organoids for Translational Neuroscience

利用离体切片和体外类器官构建人脑模型以进行转化神经科学研究

Nogueira, Giovanna O; Garcez, Patricia P; Bardy, Cedric; Cunningham, Mark O; Sebollela, Adriano

A freeze-and-thaw-induced fragment of the microtubule-associated protein tau in rat brain extracts: implications for the biochemical assessment of neurotoxicity

大鼠脑提取物中微管相关蛋白tau的冻融诱导片段:对神经毒性生化评估的意义

Vasconcelos, Israel C; Campos, Raquel M; Schwaemmle, Hanna K; Masson, Ana P; Ferrari, Gustavo D; Alberici, Luciane C; Faça, Vitor M; Garcia-Cairasco, Norberto; Sebollela, Adriano

Antibody Fragments as Tools for Elucidating Structure-Toxicity Relationships and for Diagnostic/Therapeutic Targeting of Neurotoxic Amyloid Oligomers

抗体片段作为阐明结构-毒性关系和诊断/治疗靶向神经毒性淀粉样蛋白寡聚体的工具

Bitencourt, André L B; Campos, Raquel M; Cline, Erika N; Klein, William L; Sebollela, Adriano

A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers

靶向并中和高分子量致病性淀粉样蛋白-β寡聚体的人类 scFv 抗体

Adriano Sebollela, Erika N Cline, Izolda Popova, Kevin Luo, Xiaoxia Sun, Jay Ahn, Milena A Barcelos, Vanessa N Bezerra, Natalia M Lyra E Silva, Jason Patel, Nathalia R Pinheiro, Lei A Qin, Josette M Kamel, Anthea Weng, Nadia DiNunno, Adrian M Bebenek, Pauline T Velasco, Kirsten L Viola, Pascale N La

Elucidating molecular mass and shape of a neurotoxic Aβ oligomer

阐明神经毒性Aβ寡聚体的分子量和形状

Sebollela, Adriano; Mustata, Gina-Mirela; Luo, Kevin; Velasco, Pauline T; Viola, Kirsten L; Cline, Erika N; Shekhawat, Gajendra S; Wilcox, Kyle C; Dravid, Vinayak P; Klein, William L

Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers

美金刚可以缓解高分子量β2寡聚体引起的短暂性认知障碍,但不能缓解低分子量寡聚体引起的持续性认知障碍。

Figueiredo, Cláudia P; Clarke, Julia R; Ledo, José Henrique; Ribeiro, Felipe C; Costa, Carine V; Melo, Helen M; Mota-Sales, Axa P; Saraiva, Leonardo M; Klein, William L; Sebollela, Adriano; De Felice, Fernanda G; Ferreira, Sergio T

Synapse-binding subpopulations of Aβ oligomers sensitive to peptide assembly blockers and scFv antibodies

对肽组装阻断剂和 scFv 抗体敏感的 Aβ 寡聚体的突触结合亚群

Pauline T Velasco, Marie C Heffern, Adriano Sebollela, Izolda A Popova, Pascale N Lacor, Kevin B Lee, Xiaoxia Sun, Benjamin N Tiano, Kirsten L Viola, Amanda L Eckermann, Thomas J Meade, William L Klein