日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

FGTI-2734 Inhibits ERK Reactivation to Overcome Sotorasib Resistance in KRAS G12C Lung Cancer.

FGTI-2734 抑制 ERK 再激活以克服 KRAS G12C 肺癌中的索托拉西布耐药性

Kazi Aslamuzzaman, Vasiyani Hitesh, Ghosh Deblina, Bandyopadhyay Dipankar, Shah Rachit D, Vudatha Vignesh, Trevino Jose, Sebti Said M

Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress response

TP53突变型急性髓系白血病的化疗耐药性需要甲羟戊酸的副产物——香叶基香叶基焦磷酸——来诱导适应性应激反应。

Skuli, Sarah J; Bakayoko, A'ishah; Kruidenier, Marisa; Manning, Bryan; Pammer, Paige; Salimov, Akmal; Riley, Owen; Brake-Sillá, Gisela; Dopkin, Derrick; Bowman, Michael; Martinez-Gutierrez, Leslie N; Anderson, Colin C; Reisz, Julie A; Buono, Roberta; Paul, Madhuri; Saland, Estelle; Liccardo, Francesca; DeVine, Ann; Wong, Sarah; Xu, Jimmy P; Nee, Eva; Hausler, Ryan; Boettcher, Steffen; Sebti, Said M; Lai, Catherine; Maxwell, Kara N; Sarry, Jean-Emmanuel; Fruman, David A; D'Alessandro, Angelo; Mesaros, Clementina; Keith, Brian; Simon, M Celeste; Sung, Pamela J; Wertheim, Gerald; Skuli, Nicolas; Bowman, Robert L; Matthews, Andrew; Carroll, Martin

IL-33-mediated mast cell and eosinophil function requires isoprenylation.

IL-33 介导的肥大细胞和嗜酸性粒细胞功能需要异戊二烯化。

Burchett Jason R, Kotha Aditya, Davis Destiny T, Jackson Kaitlyn G, Dailey Jordan M, Maldonado Tania D, Haque Tamara T, Hussain Zakaria Y, Ching John M, Frischmeyer-Guerrerio Pamela, Sebti Said M, Ryan John J

Design and Evaluation of Bivalent K-Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I.

设计和评估靶向 CAAX 结合位点和法尼基转移酶及香叶基香叶基转移酶 I 酸性表面的二价 K-Ras 抑制剂

Horiuchi Naomi, Omer Rania, Sugino Fumitoshi, Ogino Nanami, Inoue Yoshihisa, Aslamuzzaman Kazi, Suzuki Takeyuki, Sebti Said M, Ohkanda Junko

Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate

匹伐他汀通过消耗牻牛儿基焦磷酸盐来对抗急性髓系白血病中的维奈托克耐药机制。

Buono, Roberta; Juarez, Dennis; Paul, Madhuri; Skuli, Sarah J; Wong, Ian B; Tarnekar, Ishita; Ying, Zhili; Le, Izabelle; Wertheim, Gerald; Bakayoko, A'ishah; Kruidenier, Marisa; Sebti, Said M; Konopleva, Marina; Fleischman, Angela G; Jang, Cholsoon; Carroll, Martin; Fruman, David A

Correction: Porphyrin overdrive rewires cancer cell metabolism

更正:卟啉过载重塑癌细胞代谢

Adapa, Swamy R; Hunter, Gregory A; Amin, Narmin E; Marinescu, Christopher; Borsky, Andrew; Sagatys, Elizabeth M; Sebti, Said M; Reuther, Gary W; Ferreira, Gloria C; Jiang, Rays Hy

Dual JAK2/Aurora kinase A inhibition prevents human skin graft rejection by allo-inactivation and ILC2-mediated tissue repair

双重JAK2/Aurora激酶A抑制可通过同种异体失活和ILC2介导的组织修复来预防人皮肤移植排斥反应。

Walton, Kelly; Walker, Kirsti; Riddle, Megan; Koehn, Brent H; Reff, Jordan; Sagatys, Elizabeth M; Linden, Michael A; Pidala, Joseph; Kim, Jongphil; Lee, Marie C; Kiluk, John V; Hui, Jane Yuet Ching; Yun, Sang Y; Xing, Yan; Stefanski, Heather; Lawrence, Harshani R; Lawrence, Nicholas J; Tolar, Jakub; Anasetti, Claudio; Blazar, Bruce R; Sebti, Said M; Betts, Brian C

Pacritinib Combined with Sirolimus and Low-Dose Tacrolimus for GVHD Prevention after Allogeneic Hematopoietic Cell Transplantation: Preclinical and Phase I Trial Results

帕克替尼联合西罗莫司和低剂量他克莫司用于异基因造血干细胞移植后移植物抗宿主病预防:临床前和I期试验结果

Pidala, Joseph; Walton, Kelly; Elmariah, Hany; Kim, Jongphil; Mishra, Asmita; Bejanyan, Nelli; Nishihori, Taiga; Khimani, Farhad; Perez, Lia; Faramand, Rawan G; Davila, Marco L; Nieder, Michael L; Sagatys, Elizabeth M; Holtan, Shernan G; Lawrence, Nicholas J; Lawrence, Harshani R; Blazar, Bruce R; Anasetti, Claudio; Sebti, Said M; Betts, Brian C

Metabolic reprogramming augments potency of human pSTAT3-inhibited iTregs to suppress alloreactivity

代谢重编程增强了人pSTAT3抑制的iTregs抑制同种异体反应的能力

Walton, Kelly; Fernandez, Mario R; Sagatys, Elizabeth M; Reff, Jordan; Kim, Jongphil; Lee, Marie Catherine; Kiluk, John V; Hui, Jane Yuet Ching; McKenna, David Jr; Hupp, Meghan; Forster, Colleen; Linden, Michael A; Lawrence, Nicholas J; Lawrence, Harshani R; Pidala, Joseph; Pavletic, Steven Z; Blazar, Bruce R; Sebti, Said M; Cleveland, John L; Anasetti, Claudio; Betts, Brian C

A Phase I Study of GGTI-2418 (Geranylgeranyl Transferase I Inhibitor) in Patients with Advanced Solid Tumors

GGTI-2418(牻牛儿基牻牛儿基转移酶 I 抑制剂)治疗晚期实体瘤患者的 I 期研究

Karasic, Thomas B; Chiorean, E Gabriela; Sebti, Said M; O'Dwyer, Peter J