日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular mechanisms limiting the AAV gene therapy treatment window in mouse models of blue cone monochromacy

限制蓝锥单色视小鼠模型中AAV基因治疗窗口的分子机制

Brothers, Brooke A; Sechrest, Emily R; Ma, Li; Ashcraft, Madyson E; Guan, Tongju; Barbera, Robert J; Shaw, Lee M; Chen, Becky; Baehr, Wolfgang; Hu, Gangqing; Stoilov, Peter; Deng, Wen-Tao

P23H rhodopsin accumulation causes transient disruptions to synaptic protein levels in rod photoreceptors in a model of retinitis pigmentosa.

在视网膜色素变性模型中,P23H 视紫红质的积累会导致视杆感光细胞突触蛋白水平的短暂紊乱

Thompson Samantha L, Crowder Sophie M, Hekmatara Maryam, Sechrest Emily R, Deng Wen-Tao, Robichaux Michael A

Structural and functional rescue of cones carrying the most common cone opsin C203R missense mutation

针对携带最常见视锥细胞视蛋白C203R错义突变的视锥细胞进行结构和功能恢复

Sechrest, Emily R; Ma, Xiaojie; Cahill, Marion E; Barbera, Robert J; Wang, Yixiao; Deng, Wen-Tao

Expression of red/green-cone opsin mutants K82E, P187S, M273K result in unique pathobiological perturbations to cone structure and function.

红/绿锥视蛋白突变体 K82E、P187S、M273K 的表达导致视锥细胞结构和功能出现独特的病理生物学扰动

Sechrest Emily R, Barbera Robert J, Ma Xiaojie, Dyka Frank, Ahn Junyeop, Brothers Brooke A, Cahill Marion E, Hall Isaac, Baehr Wolfgang, Deng Wen-Tao

Blue cone monochromacy and gene therapy

蓝锥单色视和基因治疗

Sechrest, Emily R; Chmelik, Kathryn; Tan, Wendy D; Deng, Wen-Tao