日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability

FANCD2 和 RAD51 重组酶直接抑制停滞复制叉处的 DNA2 核酸酶,并且 FANCD2 作为一种新型的 RAD51 介导因子参与链交换,从而促进基因组稳定性。

Wenpeng Liu ,Piotr Polaczek ,Ivan Roubal ,Yuan Meng ,Won-Chae Choe ,Marie-Christine Caron ,Carl A Sedgeman ,Yu Xi ,Changwei Liu ,Qiong Wu ,Li Zheng ,Jean-Yves Masson ,Binghui Shen ,Judith L Campbell

ZFP36-mediated mRNA decay regulates metabolism

ZFP36介导的mRNA降解调控代谢

Andrew C Cicchetto ,Elsie C Jacobson ,Hannah Sunshine ,Blake R Wilde ,Abigail S Krall ,Kelsey E Jarrett ,Leslie Sedgeman ,Martin Turner ,Kathrin Plath ,M Luisa Iruela-Arispe ,Thomas Q de Aguiar Vallim ,Heather R Christofk

FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption

FXR 激活可通过胆汁酸依赖性减少脂质吸收来预防 NAFLD

Bethan L Clifford, Leslie R Sedgeman, Kevin J Williams, Pauline Morand, Angela Cheng, Kelsey E Jarrett, Alvin P Chan, Madelaine C Brearley-Sholto, Annika Wahlström, Julianne W Ashby, William Barshop, James Wohlschlegel, Anna C Calkin, Yingying Liu, Anders Thorell, Peter J Meikle, Brian G Drew, Julia

Dietary and Pharmacologic Manipulations of Host Lipids and Their Interaction With the Gut Microbiome in Non-human Primates

宿主脂质的饮食和药理操纵及其与非人类灵长类动物肠道微生物组的相互作用

Jennifer M Lang, Leslie R Sedgeman, Lei Cai, Joseph D Layne, Zhen Wang, Calvin Pan, Richard Lee, Ryan E Temel, Aldons J Lusis

Beta cell secretion of miR-375 to HDL is inversely associated with insulin secretion

miR-375 向 HDL 的 β 细胞分泌与胰岛素分泌呈负相关

Leslie R Sedgeman, Carine Beysen, Marisol A Ramirez Solano, Danielle L Michell, Quanhu Sheng, Shilin Zhao, Scott Turner, MacRae F Linton, Kasey C Vickers

Intestinal bile acid sequestration improves glucose control by stimulating hepatic miR-182-5p in type 2 diabetes

肠道胆汁酸封存通过刺激 2 型糖尿病中的肝脏 miR-182-5p 改善血糖控制

Leslie R Sedgeman, Carine Beysen, Ryan M Allen, Marisol A Ramirez Solano, Scott M Turner, Kasey C Vickers

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation

胰高血糖素信号传导中断揭示肝脏α细胞轴及L-谷氨酰胺在α细胞增殖中的作用

Dean, E Danielle; Li, Mingyu; Prasad, Nripesh; Wisniewski, Scott N; Von Deylen, Alison; Spaeth, Jason; Maddison, Lisette; Botros, Anthony; Sedgeman, Leslie R; Bozadjieva, Nadejda; Ilkayeva, Olga; Coldren, Anastasia; Poffenberger, Greg; Shostak, Alena; Semich, Michael C; Aamodt, Kristie I; Phillips, Neil; Yan, Hai; Bernal-Mizrachi, Ernesto; Corbin, Jackie D; Vickers, Kasey C; Levy, Shawn E; Dai, Chunhua; Newgard, Christopher; Gu, Wei; Stein, Roland; Chen, Wenbiao; Powers, Alvin C

Formation of S-[2-(N6-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Translesion DNA Polymerases

DNA 中 S-[2-(N6-脱氧腺苷基)乙基]谷胱甘肽的形成以及通过跨损伤 DNA 聚合酶进行的加合物复制

Carl A Sedgeman, Yan Su, F Peter Guengerich