Discovery of an Atropisomeric PI3Kβ Selective Inhibitor through Optimization of the Hinge Binding Motif
通过优化铰链结合基序发现一种轴手性PI3Kβ选择性抑制剂
期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.0c00095
Perreault, Stephane; Arjmand, Fatima; Chandrasekhar, Jayaraman; Hao, Jia; Keegan, Kathleen S; Koditek, David; Lepist, Eve-Irene; Matson, Clinton K; McGrath, Mary E; Patel, Leena; Sedillo, Kassandra; Therrien, Joseph; Till, Nicholas A; Tomkinson, Adrian; Treiberg, Jennifer; Zherebina, Yelena; Phillips, Gary