日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and Characterization of a First-in-Class LIV1-TLR7/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity.

发现并表征了具有强大髓系激活和抗肿瘤活性的首创 LIV1-TLR7/8 免疫调节偶联物

Yamazoe Sayumi, Poudel Yam, Sega Emanuela, Mukhopadhyay Anandaroop, Ramakrishnan Radha, Ukairo Okechukwu, Liu Scot, Akter Rahima, Sadanala Keerthi, Que Kathryn, Cheng Qinqin, Kotapati Srikanth, Deshpande Madhura, Cox Matthew, Chourey Shishir, Gupta Anuradha, Kempson James, Pabbisetty Kumar, Kaspady Mahammed, Bhattasali Debabrata, Yip Shiuhang, Wu Dauh-Rurng, Pookot Deepa, Li Yvonne, Kozhich Alexander, Drexler Dieter, Carl Stephen, Deyanova Ekaterina, Smith Michael, Chan Henry, West Sean, Diong S J, Chang Aram, Florin Lore, Mathur Arvind, Strop Pavel, Zapf Christoph W, Law Deborah, Wilson Nicholas, Broz Miranda, Chekler Eugene P

Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach

基于结构的新型TLR7/8激动剂有效载荷设计,可实现免疫调节偶联物策略

Poudel, Yam B; Lo, Julian C; Norris, Derek J; Cox, Matthew; He, Liqi; Johnson, Walter L; A M Subbaiah, Murugaiah; Mondal, Santigopal; Thangavel, Soodamani; Subramani, Lakshumanan; Reddy, Maheswara; Jain, Suraksha; Weiss, Dahlia R; Sivaprakasam, Prasanna; Critton, David; Mulligan, Dawn; Xie, Chunshan; Dhar, Payal; Li, Yvonne; Sega, Emanuela; Yamazoe, Sayumi; Gavai, Ashvinikumar V; Mathur, Arvind; Zapf, Christoph W; Chekler, Eugene P

Targeted Delivery of TLR7 Agonists to the Tumor Microenvironment Enhances Tumor Immunity via Activation of Tumor-Resident Myeloid Cells

将TLR7激动剂靶向递送至肿瘤微环境可通过激活肿瘤驻留髓系细胞增强肿瘤免疫力

Sega, Emanuela; Kotapati, Srikanth; Poudel, Yam B; Cheng, Qinqin; Sadanala, Keerthi; Schneider, Bridget; Chekler, Eugene P; Rao, Chetana; Gangwar, Sanjeev; Sproul, Tim; Law, Deborah; Broz, Miranda; Strop, Pavel; Yamazoe, Sayumi

Antitumor efficacy and reduced toxicity using an anti-CD137 Probody therapeutic

使用抗CD137前体抗体疗法可提高抗肿瘤疗效并降低毒性。

Etxeberria, Iñaki; Bolaños, Elixabet; Teijeira, Alvaro; Garasa, Saray; Yanguas, Alba; Azpilikueta, Arantza; Kavanaugh, William M; Vasiljeva, Olga; Belvin, Marcia; Howng, Bruce; Irving, Bryan; Tipton, Kimberly; West, James; Mei, Li; Korman, Alan J; Sega, Emanuela; Olivera, Irene; Cirella, Assunta; Ochoa, Maria C; Rodriguez, Maria E; Melero, Ana; Sanmamed, Miguel F; Engelhardt, John J; Melero, Ignacio

In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity

细胞因子诱导的杀伤细胞在体内迁移和存活,从而最大限度地减少移植物抗宿主病(GVHD),并保持抗肿瘤活性。

Nishimura, Ryosei; Baker, Jeanette; Beilhack, Andreas; Zeiser, Robert; Olson, Janelle A; Sega, Emanuela I; Karimi, Mobin; Negrin, Robert S

Issues related to targeted delivery of proteins and peptides

与蛋白质和肽的靶向递送相关的问题

Lu, Yingjuan; Yang, Jun; Sega, Emanuela