日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A split luciferase biosensing platform for detection and imaging of chromatin loops in individual live cells

一种用于检测和成像单个活细胞中染色质环的分裂型荧光素酶生物传感平台

Heath, Nicholas G; Gomez, J Antonio; McGinty, Sean P; O'Geen, Henriette; Segal, David J

A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition.

Angelman 综合征的临床前猪模型反映了人类疾病的早期发展轨迹

Myers Luke S, Christian Sarah G, Simpson Sean, Sper Renan, Taylor Clint, Montes Laura, Jepp Thomas B C, Ramos Daniela, Schuller Livia, Konganti Kranti, Friedeck Wade, Habib Ozair, Hodge McKaela, Taylor Alasdair J, Coffell Ashley, Schlafer Annalise, Matt Morgan, Revell Bradley, Knight Carol, Barreña Cristina C, Murphy William J, Weeber Edwin J, Segal David J, Anderson Anne, Nash Kevin R, Silverman Jill L, Piedrahita Jorge A, Dindot Scott V

Dr.Nod: computational framework for discovery of regulatory non-coding drivers in tissue-matched distal regulatory elements

Nod博士:用于发现组织匹配的远端调控元件中非编码调控驱动基因的计算框架

Tomkova, Marketa; Tomek, Jakub; Chow, Julie; McPherson, John D; Segal, David J; Hormozdiari, Fereydoun

Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing

KRAB-dCas9 + DNMT3 和 Ezh2-dCas9 + DNMT3 瞬时表观基因组编辑中可遗传基因沉默的决定因素

O'Geen, Henriette; Tomkova, Marketa; Combs, Jacquelyn A; Tilley, Emma K; Segal, David J

The promise of gene editing: so close and yet so perilously far

基因编辑的希望:近在咫尺,却又危机四伏

Segal, David J

The NIH Somatic Cell Genome Editing program

美国国立卫生研究院体细胞基因组编辑计划

Saha, Krishanu; Sontheimer, Erik J; Brooks, P J; Dwinell, Melinda R; Gersbach, Charles A; Liu, David R; Murray, Stephen A; Tsai, Shengdar Q; Wilson, Ross C; Anderson, Daniel G; Asokan, Aravind; Banfield, Jillian F; Bankiewicz, Krystof S; Bao, Gang; Bulte, Jeff W M; Bursac, Nenad; Campbell, Jarryd M; Carlson, Daniel F; Chaikof, Elliot L; Chen, Zheng-Yi; Cheng, R Holland; Clark, Karl J; Curiel, David T; Dahlman, James E; Deverman, Benjamin E; Dickinson, Mary E; Doudna, Jennifer A; Ekker, Stephen C; Emborg, Marina E; Feng, Guoping; Freedman, Benjamin S; Gamm, David M; Gao, Guangping; Ghiran, Ionita C; Glazer, Peter M; Gong, Shaoqin; Heaney, Jason D; Hennebold, Jon D; Hinson, John T; Khvorova, Anastasia; Kiani, Samira; Lagor, William R; Lam, Kit S; Leong, Kam W; Levine, Jon E; Lewis, Jennifer A; Lutz, Cathleen M; Ly, Danith H; Maragh, Samantha; McCray, Paul B Jr; McDevitt, Todd C; Mirochnitchenko, Oleg; Morizane, Ryuji; Murthy, Niren; Prather, Randall S; Ronald, John A; Roy, Subhojit; Roy, Sushmita; Sabbisetti, Venkata; Saltzman, W Mark; Santangelo, Philip J; Segal, David J; Shimoyama, Mary; Skala, Melissa C; Tarantal, Alice F; Tilton, John C; Truskey, George A; Vandsburger, Moriel; Watts, Jonathan K; Wells, Kevin D; Wolfe, Scot A; Xu, Qiaobing; Xue, Wen; Yi, Guohua; Zhou, Jiangbing

Excessive Laughter-like Vocalizations, Microcephaly, and Translational Outcomes in the Ube3a Deletion Rat Model of Angelman Syndrome

安格曼综合征Ube3a缺失大鼠模型中过度笑声样发声、小头畸形和转化结果

Berg, Elizabeth L; Jami, Shekib A; Petkova, Stela P; Berz, Annuska; Fenton, Timothy A; Lerch, Jason P; Segal, David J; Gray, John A; Ellegood, Jacob; Wöhr, Markus; Silverman, Jill L

Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion

构建一种具有完全Ube3a基因缺失的新型Angelman综合征大鼠模型

Dodge, Andie; Peters, Melinda M; Greene, Hayden E; Dietrick, Clifton; Botelho, Robert; Chung, Diana; Willman, Jonathan; Nenninger, Austin W; Ciarlone, Stephanie; Kamath, Siddharth G; Houdek, Pavel; Sumová, Alena; Anderson, Anne E; Dindot, Scott V; Berg, Elizabeth L; O'Geen, Henriette; Segal, David J; Silverman, Jill L; Weeber, Edwin J; Nash, Kevin R

Live-Animal Epigenome Editing: Convergence of Novel Techniques

活体动物表观基因组编辑:新技术的融合

Gomez, J Antonio; Beitnere, Ulrika; Segal, David J

Grand Challenges in Gene and Epigenetic Editing for Neurologic Disease

神经系统疾病基因和表观遗传编辑面临的重大挑战

Segal, David J