日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis

血清和糖皮质激素诱导的激酶Sgk1直接促进结直肠癌细胞分化并抑制转移

期刊:Clinical Cancer Research
影响因子:10
doi:10.1158/1078-0432.CCR-18-1033
Lennard Y W Lee, Connor Woolley, Thomas Starkey, Sujata Biswas, Tia Mirshahi, Chiara Bardella, Stefania Segditsas, Shazia Irshad, Ian Tomlinson
免疫
细胞生物学
肠癌
肿瘤细胞
发表日期：2019
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A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts

Wnt信号通路和干细胞数量的基础梯度影响人和小鼠肠道内区域肿瘤的分布。

期刊:Gut
影响因子:25.8
doi:10.1136/gutjnl-2011-301601
Leedham, Simon J; Rodenas-Cuadrado, Pedro; Howarth, Kimberley; Lewis, Annabelle; Mallappa, Sreelakshmi; Segditsas, Stefania; Davis, Hayley; Jeffery, Rosemary; Rodriguez-Justo, Manuel; Keshav, Satish; Travis, Simon P L; Graham, Trevor A; East, James; Clark, Susan; Tomlinson, Ian P M
肿瘤
发育与干细胞
肿瘤免疫
信号转导
Wnt/β-Catenin
干细胞
细胞生物学
发表日期：2013
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Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1

遗传性混合性息肉综合征是由上游40 kb的重复序列引起的，该重复序列导致BMP拮抗剂GREM1的表达增加和异位表达。

期刊:Nature Genetics
影响因子:29
doi:10.1038/ng.2263
Jaeger, Emma; Leedham, Simon; Lewis, Annabelle; Segditsas, Stefania; Becker, Martin; Cuadrado, Pedro Rodenas; Davis, Hayley; Kaur, Kulvinder; Heinimann, Karl; Howarth, Kimberley; East, James; Taylor, Jenny; Thomas, Huw; Tomlinson, Ian
GREM1
发表日期：2012
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The C-terminus of Apc does not influence intestinal adenoma development or progression.

Apc 的 C 端不影响肠道腺瘤的发生或发展

期刊:Journal of Pathology
影响因子:5.2
doi:10.1002/path.2972
Lewis Annabelle, Davis Hayley, Deheragoda Maesha, Pollard Patrick, Nye Emma, Jeffery Rosemary, Segditsas Stefania, East Philip, Poulsom Richard, Stamp Gordon, Wright Nicholas, Tomlinson Ian
肿瘤
发表日期：2012
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Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation

结直肠肿瘤中血清/糖皮质激素调节激酶 1 的下调很大程度上与启动子高甲基化无关

期刊:PLoS One
影响因子:2.9
doi:10.1371/journal.pone.0013840
Francesca Lessi, Andrew Beggs, Mariagrazia de Palo, Marcello Anti, Raffaele Macarone Palmieri, Simona Francesconi, Vito Gomes, Generoso Bevilacqua, Ian Tomlinson, Stefania Segditsas
肿瘤
发表日期：2010
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The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression

Apc 1322T 小鼠患上与亚最大核 β-catenin 表达相关的严重息肉病

期刊:Gastroenterology
影响因子:25.7
doi:10.1053/j.gastro.2009.02.058
Patrick Pollard, Maesha Deheragoda, Stefania Segditsas, Annabelle Lewis, Andrew Rowan, Kimberley Howarth, Lisa Willis, Emma Nye, Amy McCart, Nikki Mandir, Andrew Silver, Robert Goodlad, Gordon Stamp, Matthew Cockman, Philip East, Bradley Spencer-Dene, Richard Poulsom, Nicholas Wright, Ian Tomlinson
信号转导
Wnt/β-Catenin
Mouse
发表日期：2009
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Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice

通过人类和小鼠 APC 突变肠腺瘤中一致的基因表达变化确定假定的直接和间接 Wnt 靶点

期刊:Human Molecular Genetics
影响因子:3.1
doi:10.1093/hmg/ddn286
Stefania Segditsas, Oliver Sieber, Maesha Deheragoda, Phil East, Andrew Rowan, Rosemary Jeffery, Emma Nye, Susan Clark, Bradley Spencer-Dene, Gordon Stamp, Richard Poulsom, Nirosha Suraweera, Andrew Silver, Mohammad Ilyas, Ian Tomlinson
信号转导
Wnt/β-Catenin
Human
发表日期：2008
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Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.

对无种系 APC 或 MYH/MUTYH 突变的多发性结直肠腺瘤患者的致病机制进行研究

期刊:British Journal of Cancer
影响因子:6.8
doi:10.1038/sj.bjc.6603789
Thirlwell C, Howarth K M, Segditsas S, Guerra G, Thomas H J W, Phillips R K S, Talbot I C, Gorman M, Novelli M R, Sieber O M, Tomlinson I P M
肿瘤
发表日期：2007
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