日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Safety and efficacy of crenezumab in cognitively unimpaired carriers of the PSEN1(Glu280Ala) mutation at risk for autosomal-dominant Alzheimer's disease in Colombia (API ADAD Colombia Trial): a phase 2, randomised, double-blind, placebo-controlled trial

在哥伦比亚,一项针对认知功能正常的、携带PSEN1(Glu280Ala)突变且有常染色体显性遗传阿尔茨海默病风险的人群的克雷尼珠单抗安全性和有效性研究(API ADAD Colombia试验):一项2期随机、双盲、安慰剂对照试验

Tariot, Pierre N; Lopera, Francisco S; Ríos-Romenets, Silvia; Sink, Kaycee M; Giraldo-Chica, Margarita; Acosta-Baena, Natalia; Villegas, Gustavo; Espinosa, Alejandro; Castaño, Marisol Londoño; Muñoz, Claudia; Ospina, Paula; Bocanegra, Yamile; Tirado, Victoria; Henao, Eliana; Cardona, Eugenia; Luna, Ernesto; Lopez, Hugo; Sánchez, Gregorio; Collazos, Mario Muñoz; Alvarez, Sergio; Aguillón, David; Hu, Nan; Clayton, David; Bittner, Tobias; Schneider, Andres; Dolton, Michael; Poon, Victor; Nguyen, Jonas; Thomas, Ronald G; Schneider, Lon S; Chen, Kewei; Su, Yi; Alexander, Robert C; Quiroz, Yakeel T; Cai, Yuqi; Xu, Yi Ran; Ostaszewski, Beth; Selkoe, Dennis J; Ashton, Nicholas J; Denkinger, Marisa N; Jakimovich, Laura J; Doody, Rachelle S; Langbaum, Jessica B; Reiman, Eric M

Plasma phosphorylated tau 217 and longitudinal trajectories of Aβ, tau, and cognition in cognitively unimpaired older adults

血浆磷酸化tau蛋白217与认知功能正常老年人Aβ、tau蛋白和认知功能的纵向变化轨迹

Yang, Hyun-Sik; Anzai, Juliana A U; Yau, Wai-Ying Wendy; Healy, Brian C; Román Viera, Andrea M; Maa, Courtney; Kirn, Dylan; Properzi, Michael J; Bellier, Jean-Pierre; Schultz, Aaron P; Farrell, Michelle E; Jacobs, Heidi I L; Buckley, Rachel F; Papp, Kathryn V; Marshall, Gad A; Amariglio, Rebecca E; Rentz, Dorene M; Liu, Lei; Selkoe, Dennis J; Verghese, Philip B; Braunstein, Joel B; Johnson, Keith A; Sperling, Reisa A; Chhatwal, Jasmeer P

Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer's disease brain

抗淀粉样蛋白抗体与来自人类阿尔茨海默病脑组织的Aβ聚集体的平衡结合

Bjørnholm, Katrine D; Butler, P Monroe; Francis, Anna E; Varma, Curran; Spooner, Emma T; Grenon, Martine B; Xu, Yi Ran; Tao, Youqi; Meunier, Angela L; Anderson, Amirah K; Hennessey, Elizabeth L; Miller, Michael B; Selkoe, Dennis J; Lemere, Cynthia A; Stern, Andrew M

Higher-molecular-weight a-synuclein oligomers are increased in the brain cytosol of patients with dementia with Lewy bodies.

路易体痴呆症患者的脑细胞质中高分子量α-突触核蛋白寡聚体增多。

Gregersen Emil, Antorini Mia R, Reimer Lasse, Zaccagnini Ludovica, Selkoe Dennis, Bartels Tim, Jensen Poul Henning

Lipid membrane remodeling by myristic acid treatment reverses Parkinson's disease α-synuclein phenotypes in patient neurons

肉豆蔻酸治疗引起的脂质膜重塑可逆转帕金森病患者神经元中的α-突触核蛋白表型

Pacheco, Julian Avila; Sauli, Gleidia; Fonseca-Ornelas, Luis; Cirka, Haley; Kumari, Deepa; Hazo, Morgan; Jeanfavre, Sarah; Vendramini, Pedro H; Muratore, Christina R; Clish, Clary B; Selkoe, Dennis; Fanning, Saranna

Plasma levels of an N-terminal tau fragment predict Alzheimer's and neurodegenerative disease biomarkers in autosomal dominant Alzheimer's disease

血浆中N端tau蛋白片段的水平可预测常染色体显性遗传阿尔茨海默病中的阿尔茨海默病和神经退行性疾病生物标志物

Schultz, Stephanie A; Rao, Yiwen; Liu, Lei; Ostaszewski, Beth; Anderson, Amirah K; Yau, Wai-Ying Wendy; Shirzadi, Zahra; Gordon, Brian A; Hassenstab, Jason; Morris, John C; Perrin, Richard J; Allegri, Ricardo F; Barthélemy, Nicolas R; Fox, Nick; Day, Gregory S; Jucker, Mathias; Levey, Allan I; Levin, Johannes; Mori, Hiroshi; Salloway, Stephen; Schofield, Peter; McDade, Eric; Sperling, Reisa A; Bateman, Randall J; Selkoe, Dennis J; Chhatwal, Jasmeer P

Immune checkpoint TIM-3 regulates microglia and Alzheimer's disease.

免疫检查点TIM-3调节小胶质细胞和阿尔茨海默病

Kimura Kimitoshi, Subramanian Ayshwarya, Yin Zhuoran, Khalilnezhad Ahad, Wu Yufan, He Danyang, Dixon Karen O, Chitta Udbhav Kasyap, Ding Xiaokai, Adhikari Niraj, Guzchenko Isabell, Zhang Xiaoming, Tang Ruihan, Pertel Thomas, Myers Samuel A, Aastha Aastha, Nomura Masashi, Eskandari-Sedighi Ghazaleh, Singh Vasundhara, Liu Lei, Lambden Conner, Kleemann Kilian L, Gupta Neha, Barry Jen-Li, Durao Ana, Cheng Yiran, Silveira Sebastian, Zhang Huiyuan, Suhail Aamir, Delorey Toni, Rozenblatt-Rosen Orit, Freeman Gordon J, Selkoe Dennis J, Weiner Howard L, Blurton-Jones Mathew, Cruchaga Carlos, Regev Aviv, Suvà Mario L, Butovsky Oleg, Kuchroo Vijay K

Parkinson disease is a fatty acidopathy

帕金森病是一种脂肪酸代谢紊乱疾病。

Fanning, Saranna; Selkoe, Dennis

The case for regulatory approval of amyloid-lowering immunotherapies in Alzheimer's disease based on clearcut biomarker evidence

基于明确的生物标志物证据,论证了阿尔茨海默病中降低淀粉样蛋白的免疫疗法获得监管批准的必要性。

Aisen, Paul; Bateman, Randall J; Crowther, Damian; Cummings, Jeff; Dwyer, John; Iwatsubo, Takeshi; Kosco-Vilbois, Marie; McDade, Eric; Mohs, Richard; Scheltens, Philip; Sperling, Reisa; Selkoe, Dennis

Inhibition of hippocampal mossy fiber plasticity and episodic memory by human Aβ oligomers is prevented by enhancing cAMP signaling in Alzheimer's mice.

人类 Aβ 寡聚体对海马苔状纤维可塑性和情景记忆的抑制作用可通过增强阿尔茨海默病小鼠的 cAMP 信号传导来阻止

Jin Shan-Xue, Bellier Jean-Pierre, Wells Adrienne, LIopis Paula Montero, Anekal Praju Vikas, Tresback Jason S, Caldarone Barbara J, Liu Lei, Li Shaomin, Dettmer Ulf, Ramalingam Nagendran, Selkoe Dennis J